Clinical Trials

Phase 2/3 Active not recruiting

Liposarcoma, Histiocytoma, Malignant Fibrous

NCT06881992 2026-04-14

Tumor HI

Phase 3 Recruiting

16 enrolled

EndocrineNETSarcoma

Fibrosarcoma, Hyperinsulinism, Hypoglycemia, Insulinoma, Adenoma, Islet Cell, Liposarcoma, Neoplasms, Neuroectodermal Tumors, Primitive, Neuroendocrine Tumors

NCT02180867 2026-04-13

Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery

140 enrolled 22 charts

Plasma cellSarcoma

Histiocytoma, Angiomatoid Fibrous, Chondrosarcoma, Extraskeletal Myxoid, Fibrosarcoma, Granuloma, Plasma Cell, Leiomyosarcoma, Liposarcoma, Sarcoma, Sarcoma, Synovial, Chondrosarcoma, Mesenchymal, Dermatofibrosarcoma, Sarcoma, Clear Cell, Sarcoma, Alveolar Soft Part, Nerve Sheath Neoplasms, Neurofibrosarcoma, Histiocytoma, Malignant Fibrous, Perivascular Epithelioid Cell Neoplasms

NCT02923778 2026-04-13

Talimogene Laherparepvec and Radiation Therapy in Treating Patients With Newly Diagnosed Soft Tissue Sarcoma That Can Be Removed by Surgery

40 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma, Histiocytoma, Malignant Fibrous

NCT05711615 2026-04-13

Testing Low-Dose Common Chemotherapy (Liposomal Doxorubicin) in Combination With an Anti-Cancer Drug, Peposertib, in Advanced Sarcoma

30 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma, Sarcoma, Synovial, Dermatofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT06498648 2026-04-13

Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma

74 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma

NCT06541262 2026-04-09

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

Phase 1 Active not recruiting

104 enrolled

CNSSarcoma

Liposarcoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT03361436 2026-04-08

Eribulin and Radiation Therapy in Treating Patients With Retroperitoneal Liposarcoma That Can Be Removed by Surgery

15 enrolled

Liposarcoma

NCT04715191 2026-04-06

Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

24 enrolled

Liposarcoma, Liver Neoplasms, Wilms Tumor, Rhabdomyosarcoma, Endodermal Sinus Tumor, Rhabdoid Tumor

NCT06975293 2026-04-06

STC-15 as a Part of Combination Therapy With Toripalimab in Selected Advanced Cancers and as Monotherapy in Participants With Selected Sarcomas

107 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma

NCT04031677 2026-03-31

STRASS2

Phase 3 Recruiting

250 enrolled

Leiomyosarcoma, Liposarcoma

NCT06843967 2026-03-13

A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

54 enrolled

Phase 1 Active not recruiting

Liposarcoma, Liposarcoma, Myxoid

NCT05103631 2026-03-06

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Solid Tumors

12 enrolled

Carcinoma, Hepatocellular, Liposarcoma, Liver Neoplasms, Wilms Tumor, Rhabdomyosarcoma, Endodermal Sinus Tumor, Rhabdoid Tumor

NCT03307616 2026-03-05

Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before Surgery

32 enrolled

Liposarcoma, Histiocytoma, Malignant Fibrous

NCT05218499 2026-03-02

Brightline-1: A Study to Compare Brigimadlin (BI 907828) With Doxorubicin in People With a Type of Cancer Called Dedifferentiated Liposarcoma

Phase 2/3 Completed

400 enrolled 15 charts

Liposarcoma

NCT04794127 2026-02-18

TRABEPIO

Phase 2 Completed

10 enrolled

Liposarcoma, Liposarcoma, Myxoid

NCT07148050 2026-02-17

IMPACT

21 enrolled

Carcinoma, Hepatocellular, Liposarcoma, Liver Neoplasms, Wilms Tumor, Rhabdomyosarcoma, Hepatoblastoma, Endodermal Sinus Tumor, Rhabdoid Tumor

NCT07169344 2026-01-28

PROSARC-1

110 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma, Sarcoma, Synovial, Dermatofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT07173972 2026-01-28

PROSARC-2

40 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma, Sarcoma, Synovial, Dermatofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT05694871 2026-01-26

Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma

77 enrolled

Liposarcoma

NCT06239272 2026-01-26

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

Phase 1 Active not recruiting

139 enrolled

Plasma cellSarcoma

Histiocytoma, Angiomatoid Fibrous, Chondrosarcoma, Extraskeletal Myxoid, Fibrosarcoma, Glomus Tumor, Granuloma, Plasma Cell, Hemangiosarcoma, Liposarcoma, Myoepithelioma, Sarcoma, Osteosarcoma, Disorders of Sex Development, Granular Cell Tumor, Neoplasms, Adipose Tissue, Liposarcoma, Myxoid, Dermatofibrosarcoma, Sarcoma, Clear Cell, Smooth Muscle Tumor, Nerve Sheath Neoplasms, Neurofibrosarcoma, Hemangioendothelioma, Epithelioid, Vascular Neoplasms, Solitary Fibrous Tumors

NCT04377932 2026-01-21

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

14 enrolled 12 charts

Liposarcoma, Liver Neoplasms, Wilms Tumor, Rhabdomyosarcoma, Endodermal Sinus Tumor, Rhabdoid Tumor

NCT06058793 2026-01-09

Brightline-4: A Study to Test How Well Brigimadlin is Tolerated by People With a Type of Cancer Called Dedifferentiated Liposarcoma

Phase 3 Completed

138 enrolled

Liposarcoma

NCT06849986 2026-01-08

TAIS

45 enrolled

Fibrosarcoma, Hemangiosarcoma, Leiomyosarcoma, Liposarcoma, Sarcoma, Neurofibrosarcoma, Desmoplastic Small Round Cell Tumor

NCT07089992 2025-12-16

A Study of Pembrolizumab in People With Ultra-Rare Sarcomas

32 enrolled

Liposarcoma, Sarcoma, Perivascular Epithelioid Cell Neoplasms

NCT03526679 2025-12-05

LEADER

Phase 1/2 Completed

30 enrolled 9 charts

Leiomyosarcoma, Liposarcoma, Sarcoma

NCT06116578 2025-12-01

NeoSarc

Phase 2 Withdrawn

Liposarcoma, Neoplasms, Sarcoma

NCT05496569 2025-11-21

TQB3616 Capsules in the Treatment of Dedifferentiated Liposarcoma

Phase 2 Terminated

26 enrolled

Phase 1 Not yet recruiting

Liposarcoma

NCT07224568 2025-11-04

INTERCEPT

21 enrolled

GastrointestinalSarcoma

Carcinoma, Hepatocellular, Liposarcoma, Liver Neoplasms, Rhabdomyosarcoma, Endodermal Sinus Tumor

NCT06198296 2025-11-03

Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells

21 enrolled

Carcinoma, Hepatocellular, Liposarcoma, Wilms Tumor, Rhabdomyosarcoma, Hepatoblastoma, Endodermal Sinus Tumor, Rhabdoid Tumor

NCT06414434 2025-10-31

BTX-A51 in Patients With Liposarcoma or CIC-rearranged Sarcoma

24 enrolled

Liposarcoma, Liposarcoma, Myxoid

NCT05886634 2025-10-20

A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma

16 enrolled

Liposarcoma, Sarcoma

NCT04438824 2025-10-14

Palbociclib and INCMGA00012 in People With Advanced Liposarcoma

42 enrolled

Liposarcoma

NCT04557449 2025-10-01

CDK4i

BreastGastrointestinalGenitourinarySarcomaThoracic

362 enrolled

Adenocarcinoma of Lung, Breast Neoplasms, Liposarcoma, Prostatic Neoplasms, Colorectal Neoplasms

NCT06789172 2025-09-05

INVOKE

GastrointestinalHead & NeckSarcomaThoracic

166 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Liposarcoma, Sarcoma, Colorectal Neoplasms, Dermatofibrosarcoma, Histiocytoma, Malignant Fibrous, Solitary Fibrous Tumors

NCT01841047 2025-09-03

TOMOREP

Phase NA Completed

48 enrolled 15 charts

Liposarcoma

NCT03899805 2025-08-28

A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue Sarcomas

Phase 2 Completed

57 enrolled 14 charts

Leiomyosarcoma, Liposarcoma, Sarcoma, Histiocytoma, Malignant Fibrous

NCT04242238 2025-08-28

Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas

Phase 1 Completed

32 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma, Dermatofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT06389799 2025-08-28

PERELI

33 enrolled

Liposarcoma

NCT06277154 2025-07-24

MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma

BreastDermatologicGenitourinaryGynecologicOther solid neoplasmSarcomaThoracic

148 enrolled

GynecologicSarcoma

Fibrosarcoma, Hemangiosarcoma, Leiomyosarcoma, Liposarcoma, Sarcoma, Sarcoma, Synovial, Sarcoma, Endometrial Stromal, Neurofibrosarcoma, Histiocytoma, Malignant Fibrous, Desmoplastic Small Round Cell Tumor

NCT06299163 2025-07-23

NM32-2668 in Adult Patients With Selected Advanced Solid Tumors

Phase 1 Terminated

11 enrolled

Adenocarcinoma of Lung, Mesothelioma, Malignant, Carcinoma, Renal Cell, Fallopian Tube Neoplasms, Leiomyosarcoma, Liposarcoma, Melanoma, Ovarian Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT02451943 2025-07-15

ANNOUNCE

Phase 3 Completed

509 enrolled 23 charts

Leiomyosarcoma, Liposarcoma, Sarcoma, Histiocytoma, Malignant Fibrous

NCT05580588 2025-06-13

Open-Label Study of the CDK4/6 Inhibitor SPH4336 in Subjects With Locally Advanced or Metastatic Liposarcomas

Phase 2 Terminated

14 enrolled 8 charts

Liposarcoma

NCT02846987 2025-06-05

Study of Abemaciclib in Dedifferentiated Liposarcoma

33 enrolled

Liposarcoma, Sarcoma

NCT06578624 2025-06-05

Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors

70 enrolled

Liposarcoma

NCT03719430 2025-04-29

APX005M and Doxorubicin in Advanced Sarcoma

27 enrolled