Clinical Trials

Phase 1 Active not recruiting

104 enrolled

CNSSarcoma

Liposarcoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT03361436 2026-04-08

Eribulin and Radiation Therapy in Treating Patients With Retroperitoneal Liposarcoma That Can Be Removed by Surgery

15 enrolled

Liposarcoma

NCT04715191 2026-04-06

Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

24 enrolled

Liposarcoma, Liver Neoplasms, Wilms Tumor, Rhabdomyosarcoma, Endodermal Sinus Tumor, Rhabdoid Tumor

NCT06843967 2026-03-13

A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

54 enrolled

Phase 1 Active not recruiting

Liposarcoma, Liposarcoma, Myxoid

NCT05103631 2026-03-06

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Solid Tumors

12 enrolled

Carcinoma, Hepatocellular, Liposarcoma, Liver Neoplasms, Wilms Tumor, Rhabdomyosarcoma, Endodermal Sinus Tumor, Rhabdoid Tumor

NCT03307616 2026-03-05

Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before Surgery

Liposarcoma, Histiocytoma, Malignant Fibrous

NCT07432932 2026-02-25

PANTHR-S

Recruiting

800 enrolled

Hemangiosarcoma, Leiomyosarcoma, Liposarcoma, Sarcoma

NCT04794127 2026-02-18

TRABEPIO

10 enrolled

Liposarcoma, Liposarcoma, Myxoid

NCT07148050 2026-02-17

IMPACT

21 enrolled

Carcinoma, Hepatocellular, Liposarcoma, Liver Neoplasms, Wilms Tumor, Rhabdomyosarcoma, Hepatoblastoma, Endodermal Sinus Tumor, Rhabdoid Tumor

NCT07377747 2026-01-30

ReLaPSe

Recruiting

100 enrolled

Retroperitoneal liposarcoma, Liposarcoma, Sarcoma

NCT07169344 2026-01-28

PROSARC-1

110 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma, Sarcoma, Synovial, Dermatofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT07173972 2026-01-28

PROSARC-2

40 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma, Sarcoma, Synovial, Dermatofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT05694871 2026-01-26

Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma

77 enrolled

Liposarcoma

NCT06239272 2026-01-26

NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

Phase 1 Active not recruiting

139 enrolled

Plasma cellSarcoma

Histiocytoma, Angiomatoid Fibrous, Chondrosarcoma, Extraskeletal Myxoid, Fibrosarcoma, Glomus Tumor, Granuloma, Plasma Cell, Hemangiosarcoma, Liposarcoma, Myoepithelioma, Sarcoma, Osteosarcoma, Disorders of Sex Development, Granular Cell Tumor, Neoplasms, Adipose Tissue, Liposarcoma, Myxoid, Dermatofibrosarcoma, Sarcoma, Clear Cell, Smooth Muscle Tumor, Nerve Sheath Neoplasms, Neurofibrosarcoma, Hemangioendothelioma, Epithelioid, Vascular Neoplasms, Solitary Fibrous Tumors

NCT04377932 2026-01-21

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

14 enrolled 12 charts

Liposarcoma, Liver Neoplasms, Wilms Tumor, Rhabdomyosarcoma, Endodermal Sinus Tumor, Rhabdoid Tumor

NCT06849986 2026-01-08

TAIS

45 enrolled

Fibrosarcoma, Hemangiosarcoma, Leiomyosarcoma, Liposarcoma, Sarcoma, Neurofibrosarcoma, Desmoplastic Small Round Cell Tumor

NCT07089992 2025-12-16

A Study of Pembrolizumab in People With Ultra-Rare Sarcomas

Liposarcoma, Sarcoma, Perivascular Epithelioid Cell Neoplasms

NCT03526679 2025-12-05

LEADER

Phase 1/2 Completed

30 enrolled 9 charts

Leiomyosarcoma, Liposarcoma, Sarcoma

NCT07262970 2025-12-04

Intermediate-Size Cohort EAP for Ersodetug in Patients With Inadequately Controlled Hypoglycemia Related to a Tumor

Available

EndocrineNETSarcoma

Fibrosarcoma, Hyperinsulinism, Hypoglycemia, Insulinoma, Adenoma, Islet Cell, Liposarcoma, Neoplasms, Neuroectodermal Tumors, Primitive, Neuroendocrine Tumors

NCT06116578 2025-12-01

NeoSarc

Phase 2 Withdrawn

Phase 1 Not yet recruiting

Liposarcoma, Neoplasms, Sarcoma

NCT07224568 2025-11-04

INTERCEPT

21 enrolled

GastrointestinalSarcoma

Carcinoma, Hepatocellular, Liposarcoma, Liver Neoplasms, Rhabdomyosarcoma, Endodermal Sinus Tumor

NCT06198296 2025-11-03

Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells

21 enrolled

Carcinoma, Hepatocellular, Liposarcoma, Wilms Tumor, Rhabdomyosarcoma, Hepatoblastoma, Endodermal Sinus Tumor, Rhabdoid Tumor

NCT06414434 2025-10-31

BTX-A51 in Patients With Liposarcoma or CIC-rearranged Sarcoma

24 enrolled

Liposarcoma, Liposarcoma, Myxoid

NCT05886634 2025-10-20

A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma

16 enrolled

Liposarcoma, Sarcoma

NCT04438824 2025-10-14

Palbociclib and INCMGA00012 in People With Advanced Liposarcoma

42 enrolled

Liposarcoma

NCT01841047 2025-09-03

TOMOREP

Phase NA Completed

48 enrolled 15 charts

Liposarcoma

NCT03899805 2025-08-28

A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue Sarcomas

57 enrolled 14 charts

Leiomyosarcoma, Liposarcoma, Sarcoma, Histiocytoma, Malignant Fibrous

NCT04242238 2025-08-28

Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas

Phase 1 Completed

Leiomyosarcoma, Liposarcoma, Sarcoma, Dermatofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT06389799 2025-08-28

PERELI

33 enrolled

Liposarcoma

NCT02846987 2025-06-05

Study of Abemaciclib in Dedifferentiated Liposarcoma

33 enrolled

Liposarcoma, Sarcoma

NCT03719430 2025-04-29

APX005M and Doxorubicin in Advanced Sarcoma

27 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma, Sarcoma, Synovial, Neurofibrosarcoma

NCT03114527 2025-04-04

Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)

48 enrolled

Phase EARLY_PHASE1 Terminated

Leiomyosarcoma, Liposarcoma, Sarcoma

NCT04213794 2025-02-20

TOASTIT

2 enrolled

GastrointestinalGynecologicOther solid neoplasmSarcomaThoracic

Mesothelioma, Malignant, Colonic Neoplasms, Fallopian Tube Neoplasms, Liposarcoma, Ovarian Neoplasms, Pelvic Neoplasms, Rectal Neoplasms, Rhabdomyosarcoma, Sarcoma, Stomach Neoplasms, Desmoplastic Small Round Cell Tumor

NCT04224064 2025-02-12

ESPACE

Phase NA Recruiting

158 enrolled

Liposarcoma, Neoplasms

NCT02249949 2025-01-27

Efatutazone Dihydrochloride in Treating Patients With Previously Treated Myxoid Liposarcoma That Cannot Be Removed by Surgery

15 enrolled 12 charts

Phase 2 Not yet recruiting

Liposarcoma

NCT06694324 2024-11-19

First-line Treatment of Advanced/unresectable DDLPS

49 enrolled

Liposarcoma, Sarcoma

NCT02978859 2024-07-18

Sitravatinib in Advanced Liposarcoma and Other Soft Tissue Sarcomas

29 enrolled 11 charts

Liposarcoma, Sarcoma

NCT05116683 2023-12-06

ATX-101

Phase 2 Terminated

4 enrolled 12 charts

Leiomyosarcoma, Liposarcoma

NCT02048371 2023-11-07

SARC024: A Blanket Protocol to Study Oral Regorafenib in Patients With Selected Sarcoma Subtypes

131 enrolled 22 charts

Liposarcoma, Rhabdomyosarcoma, Osteosarcoma, Chondrosarcoma, Mesenchymal

NCT02584309 2023-11-07

Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma

73 enrolled 11 charts

Fibrosarcoma, Hemangiosarcoma, Leiomyosarcoma, Liposarcoma, Sarcoma, Sarcoma, Synovial, Dermatofibrosarcoma, Neurofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT03009201 2023-08-16

Ribociclib and Doxorubicin in Treating Patients With Metastatic or Advanced Soft Tissue Sarcomas That Cannot Be Removed by Surgery

Phase 1 Completed

16 enrolled

Fibrosarcoma, Hemangiosarcoma, Liposarcoma, Sarcoma, Disorders of Sex Development, Sarcoma, Synovial, Dermatofibrosarcoma, Neurofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT00004180 2023-06-26

Rosiglitazone in Treating Patients With Liposarcoma

Liposarcoma, Sarcoma

NCT02275286 2023-05-31

TRASTS

199 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma, Liposarcoma, Myxoid

NCT00346125 2022-12-15

PET CT as Predictor of Response in Preoperative Chemotherapy for Soft Tissue Sarcoma

Phase NA Completed

70 enrolled

Fibrosarcoma, Leiomyosarcoma, Liposarcoma, Sarcoma, Sarcoma, Synovial, Neurofibrosarcoma, Histiocytoma, Malignant Fibrous

NCT03959033 2022-08-31

Patient Reported Outcome Measures (PROMs) With Trabectedin

Terminated

7 enrolled

Leiomyosarcoma, Liposarcoma, Sarcoma

NCT02357810 2022-06-07

Pazopanib Hydrochloride and Topotecan Hydrochloride in Treating Patients With Metastatic Soft Tissue and Bone Sarcomas

178 enrolled 16 charts

Liposarcoma, Sarcoma, Osteosarcoma

NCT03074318 2022-04-29

Avelumab and Trabectedin in Treating Patients With Liposarcoma or Leiomyosarcoma That is Metastatic or Cannot Be Removed by Surgery

Phase 1/2 Terminated

35 enrolled 21 charts

Leiomyosarcoma, Liposarcoma

NCT04512495 2021-12-10

SAMHY SARCOME

Phase NA Completed

60 enrolled