Clinical Trials

Phase 1 Active not recruiting

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Small Cell Lung Carcinoma

NCT04514497 2026-05-19

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

29 enrolled 25 charts

EndocrineGastrointestinalThoracic

Lung Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Carcinoma, Neuroendocrine, Small Cell Lung Carcinoma

NCT02595931 2026-05-13

M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Phase 1 Active not recruiting

66 enrolled

GastrointestinalThoracic

Lung Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Colorectal Neoplasms, Small Cell Lung Carcinoma

NCT07258147 2026-05-05

Safety and Efficacy of Radiotherapy Combined With Immunochemotherapy in Pre-treated SCLC Patients With Liver Metastases

Phase 2 Not yet recruiting

30 enrolled

Phase 2 Active not recruiting

Lung Neoplasms

NCT03678883 2026-04-03

9-ING-41 in Patients With Advanced Cancers

350 enrolled

BreastCNSGastrointestinalGenitourinaryLymphoidOther hematologic neoplasmSarcomaThoracic

Bone Neoplasms, Breast Neoplasms, Glioma, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Neoplasms, Hereditary Sensory and Autonomic Neuropathies, Pancreatic Neoplasms, Sarcoma, Colorectal Neoplasms, Leukemia-Lymphoma, Adult T-Cell

NCT02419495 2025-06-04

Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignancies

Phase 1 Terminated

221 enrolled

BreastDermatologicGenitourinaryGynecologicThoracic

Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Fallopian Tube Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Ovarian Neoplasms, Triple Negative Breast Neoplasms

NCT02489903 2025-03-17

RRx-001 in Lung Cancer, Ovarian Cancer and Neuroendocrine Tumors Prior to Re-administration of Platinum Based Doublet Regimens (QUADRUPLE THREAT)

EndocrineGynecologicNETThoracic

139 enrolled 14 charts

Carcinoma, Ovarian Epithelial, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Carcinoma, Small Cell, Neuroendocrine Tumors

NCT04173325 2022-06-14

Feasibility and Safety Study of Nivolumab With Irinotecan for Small Cell Lung Cancer

Phase 1 Terminated

10 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00025285 2021-09-09

Combination Chemotherapy Plus Thalidomide in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

46 enrolled

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02275806 2019-08-21

Cisplatin/Irinotecan With Concurrent Radiation for Inoperable NSCLC

Phase 2 Terminated

4 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00465907 2019-02-11

Study of Weekly Paclitaxel, Carboplatin and Irinotecan to Treat Lung Cancer

Phase 2 Terminated

7 enrolled

Lung Neoplasms

NCT00045162 2018-07-31

S0124: Cisplatin Combined With Irinotecan or Etoposide For Extensive-Stage Small Cell Lung Cancer

Phase 3 Completed

671 enrolled 10 charts

Lung Neoplasms

NCT00387660 2018-01-10

Irinotecan and Carboplatin in Treating Patients With Metastatic or Recurrent Small Cell Lung Cancer

80 enrolled 8 charts

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00004095 2017-04-18

Irinotecan Plus Gemcitabine in Treating Patients With Unresectable or Metastatic Solid Tumors

BreastGastrointestinalGenitourinaryThoracic

38 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Kidney Neoplasms, Lung Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms, Small Cell Lung Carcinoma

NCT00449020 2016-12-15

Carboplatin, Irinotecan, and Radiation Therapy Followed By Docetaxel in Treating Patients With Newly Diagnosed Stage III Non-Small Cell Lung Cancer

32 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00193375 2016-08-10

Irinotecan, Carboplatin and Radiation Therapy Followed by Bevacizumab in Limited Stage Small Cell Lung Cancer

60 enrolled 7 charts

Lung Neoplasms

NCT00004139 2016-07-20

Gemcitabine Plus Docetaxel or Irinotecan in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer

80 enrolled

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00005972 2016-07-14

Combination Chemotherapy in Treating Patients With Recurrent or Refractory Small Cell Lung Cancer

73 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00003900 2016-07-06

Irinotecan With Docetaxel in Treating Patients With Recurrent or Metastatic Non-small Cell Lung Cancer

48 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00072527 2016-07-06

Cisplatin and Irinotecan Followed by Carboplatin, Etoposide, and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

78 enrolled

Lung Neoplasms

NCT00059761 2015-11-17

Chemotherapy Combined With Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

36 enrolled

Lung Neoplasms

NCT00391586 2015-08-17

Erlotinib and Standard Platinum-Based Chemotherapy for Newly Diagnosed, Advanced Non-Small Cell Carcinoma of the Lung

Phase 2 Terminated

45 enrolled 4 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00052494 2015-07-23

Combination Chemotherapy and Imatinib Mesylate in Treating Patients With Extensive-Stage Small Cell Lung Cancer

9 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT01654081 2014-05-30

A Protocol of Irinotecan for Carcinoma of the Lung

Phase 2 Withdrawn

Lung Neoplasms

NCT00022308 2013-09-02

Chemotherapy and Radiation Therapy in Treating Patients With Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00003111 2013-07-25

Combination Chemotherapy Followed by Surgery in Treating Patients With Stage IIIA Non-small Cell Lung Cancer

10 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00104793 2013-05-30

Irinotecan and Carboplatin in Treating Patients With Newly Diagnosed Extensive-Stage Small Cell Lung Cancer

55 enrolled

Lung Neoplasms

NCT00132054 2013-05-30

Amrubicin and Irinotecan in Treating Patients With Recurrent or Relapsed Extensive Stage Small Cell Lung Cancer

30 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00248482 2013-04-29

Imatinib Mesylate After Irinotecan and Cisplatin in Treating Patients With Extensive-Stage Small Cell Lung Cancer

6 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00030433 2013-02-15

S0119: Combination Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer

85 enrolled

Lung Neoplasms

NCT00346801 2012-10-22

CPT-11/Cisplatin and Celecoxib With Radiation Therapy for Patients With Unresectable Non-Small Cell Lung Cancer (NSCLC)

20 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00469898 2012-07-27

Irinotecan and Carboplatin as First-Line Therapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer

50 enrolled 11 charts

Lung Neoplasms

NCT00073866 2012-07-19

Combination Chemotherapy and Celecoxib in Treating Patients With Advanced Non-Small Cell Lung Cancer

Phase 1/2 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00182806 2012-03-06

Irinotecan and Gemcitabine in Treating Patients With Recurrent or Progressive Stage III or Stage IV Non-Small Cell Lung Cancer

38 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00620269 2011-11-07

Induction Chemotherapy Followed by CCRT According to EGFR Mutation Status in NSCLC III

Phase 2 Unknown

212 enrolled

Lung Neoplasms

NCT00193349 2010-06-28

Gleevec Combined With Camptosar Plus Paraplatin in Previously Untreated Extensive Stage Small Cell Lung Cancer

60 enrolled

Lung Neoplasms

NCT00308529 2010-06-22

Irinotecan, Carboplatin, Bevacizumab, and Radiation Therapy in the Treatment of Limited Stage Small Cell Lung Cancer

55 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00062322 2010-02-12

Neoadjuvant Chemoradiotherapy Followed By Surgery in Treating Patients With Limited-Stage Small Cell Lung Cancer

Lung Neoplasms

NCT00004924 2009-08-25

Paclitaxel and Irinotecan in Treating Patients With Advanced Non-small Cell Lung Cancer

28 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00616785 2009-02-09

Combination Chemotherapy and Radiation Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery

Phase 2 Unknown

41 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00045604 2008-07-24

Imatinib Mesylate and Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer