Clinical Trials Browser

Completed × Lung Neoplasms × Pemetrexed × Clear all

NCT03607539 2026-05-11

Efficacy and Safety Evaluation of Sintilimab in Patients With Advanced or Metastatic Non-squamous NSCLC

Phase 3 Completed

397 enrolled 15 charts

Lung Neoplasms

NCT03177291 2025-12-05

Pirfenidone Combined With Standard First-Line Chemotherapy in Advanced-Stage Lung NSCLC

Phase 1 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT03132532 2025-11-25

Platinum Doublet Chemotherapy and Proton Beam Radiation Therapy in Treating Patients With Stage II-III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Phase 2 Completed

20 enrolled 20 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT05014815 2025-09-16

Ociperlimab With Tislelizumab and Chemotherapy in Participants With Untreated Metastatic Non-Small Cell Lung Cancer

Phase 2 Completed

272 enrolled 17 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT02185690 2025-08-21

MEK162

Phase 1 Completed

13 enrolled 11 charts

Carcinoma, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00284778 2025-07-24

Pharmaco-economic Study of a Second Line Treatment in Advanced Non Small Cell Lung Cancer

Phase 3 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02922764 2025-03-26

A Study of RGX-104 in Patients With Advanced Lung & Endometrial Cancer

Phase 1 Completed

GynecologicThoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms, Endometrial Neoplasms, Small Cell Lung Carcinoma

NCT02489903 2025-03-17

RRx-001 in Lung Cancer, Ovarian Cancer and Neuroendocrine Tumors Prior to Re-administration of Platinum Based Doublet Regimens (QUADRUPLE THREAT)

Phase 2 Completed

139 enrolled 14 charts

EndocrineGynecologicNETThoracic

Carcinoma, Ovarian Epithelial, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Carcinoma, Small Cell, Neuroendocrine Tumors

NCT01828112 2025-02-07

LDK378 Versus Chemotherapy in ALK Rearranged (ALK Positive) Patients Previously Treated With Chemotherapy (Platinum Doublet) and Crizotinib

Phase 3 Completed

231 enrolled 33 charts

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01828099 2025-01-16

LDK378 Versus Chemotherapy in Previously Untreated Patients With ALK Rearranged Non-small Cell Lung Cancer

Phase 3 Completed

376 enrolled 34 charts 1 FDA

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00418886 2024-12-31

ZEAL

Phase 3 Completed

698 enrolled 16 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT03432598 2024-10-23

Anti-PD-1 in Combination With Chemotherapy as First-Line Treatment to Lung Cancer

Phase 2 Completed

Lung Neoplasms

NCT03971474 2024-09-03

Ramucirumab and Pembrolizumab Versus Standard of Care in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Non-Match Treatment Trial)

Phase 2 Completed

166 enrolled 21 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04452214 2023-07-14

A Study of the Safety and Tolerance of CAN04 and Pembrolizumab in Combination With and Without Carboplatin and Pemetrexed in Subjects With Solid Tumors

Phase 1 Completed

DermatologicGenitourinaryHead & NeckThoracic

Adenocarcinoma of Lung, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Lung Neoplasms, Melanoma

NCT01126736 2023-06-22

Eribulin Mesylate Administered in Combination With Pemetrexed Versus Pemetrexed Alone as Second Line Therapy in Patients With Stage IIIB or IV Nonsquamous Non Small Cell Lung Cancer

Phase 1/2 Completed

98 enrolled 15 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00301808 2023-05-06

Cisplatin, Pemetrexed Disodium, and Radiation Therapy Followed by Docetaxel in Treating Patients With Stage III Non-Small Cell Lung Cancer

Phase 2 Completed

29 enrolled 11 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01850303 2023-03-14

MODEL

Phase 3 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00456261 2022-05-03

First-Line Treatment of A Comparison of 2 Treatments in Elderly Patients With Advanced NSCLC

Phase 2 Completed

110 enrolled 8 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00193414 2022-03-03

Pemetrexed and Gemcitabine in Patients With Advanced Non-Small Cell Lung Cancer

Phase 2 Completed

72 enrolled 9 charts

Lung Neoplasms

NCT00948675 2021-10-29

Study of Participants With Advanced Non-Small Cell Lung Cancer

Phase 3 Completed

361 enrolled 13 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02498860 2021-08-06

APICAL

Phase 2 Completed

Adenocarcinoma, Lung Neoplasms

NCT02964689 2021-07-14

Binimetinib in Addition to Standard Chemotherapy in KRAS Mutated NSCLC.

Phase 1 Completed

Lung Neoplasms

NCT03380871 2021-02-26

A Personal Cancer Vaccine (NEO-PV-01) With Pembrolizumab and Chemotherapy for Patients With Lung Cancer

Phase 1 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00434174 2020-12-21

Safety of Everolimus and Pemetrexed in Lung Cancer Patients

Phase 1 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT03256136 2020-11-04

Nivolumab in Combination With Chemotherapy, or Nivolumab in Combination With Ipilimumab, in Advanced EGFR-Mutant or ALK-Rearranged NSCLC

Phase 2 Completed

9 enrolled 15 charts

Lung Neoplasms

NCT00835471 2020-09-29

NVALT10

Phase 2 Completed

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02259582 2020-09-09

DENALI

Phase 2 Completed

82 enrolled 10 charts

Carcinoma, Lung Diseases, Lung Neoplasms, Neoplasm Metastasis, Neoplasms

NCT03134872 2020-06-09

A Study of SHR-1210 in Combination With Pemetrexed and Carboplatin in Subjects With Non-squamous NSCLC

Phase 3 Completed

Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms, Neoplasms by Site, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms

NCT02639091 2019-11-07

Phase Ib Study of Anetumab Ravtansine in Combination With Pemetrexed and Cisplatin in Mesothelin-expressing Solid Tumors

Phase 1 Completed

Other solid neoplasmThoracic

Lung Neoplasms, Mesothelioma

NCT00771953 2019-10-30

0822GCC: Phase 2 Study of Efficacy and Safety of Apricoxib/Placebo With Docetaxel or Pemetrexed in Non-Small Cell Lung Cancer

Phase 2 Completed

109 enrolled 6 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01232452 2019-09-20

A Study in Non-Small Cell Lung Cancer

Phase 2 Completed

172 enrolled 20 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01160744 2019-09-13

A Study of Pemetrexed and Carboplatin/Cisplatin or Gemcitabine and Carboplatin/Cisplatin With or Without IMC-1121B in Participants Previously Untreated With Recurrent or Advanced Non-Small Cell Lung Cancer (NSCLC)

Phase 2 Completed

280 enrolled 20 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00234052 2019-06-04

Carboplatin, Pemetrexed Disodium, and Bevacizumab in Treating Patients With Stage IIIB, Stage IV, or Recurrent Non-Small Cell Lung Cancer

Phase 2 Completed

51 enrolled 12 charts

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01116219 2019-05-15

Bevacizumab, Pemetrexed Disodium, and Cisplatin or Erlotinib Hydrochloride and Bevacizumab in Treating Patients With Stage IV Non-Small Cell Lung Cancer. A Multicenter Phase II Trial Including Biopsy at Progression (BIO-PRO Trial).

Phase 2 Completed

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01263782 2019-05-15

BATTLE-FL: Front-Line Biomarker-Integrated Treatment Study in Non Small Cell Lung Cancer

Phase 2 Completed

64 enrolled 12 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT00407550 2019-05-02

Pemetrexed Disodium and Gemcitabine in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

Phase 2 Completed

19 enrolled 11 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT02900742 2019-04-12

Clinical Study of Chinese Medicine Plus Chemotherapy Maintenance in Advanced Non Small Cell Lung Cancer

Phase 3 Completed

Lung Neoplasms, Neoplasms

NCT00389805 2018-10-31

Bortezomib and Pemetrexed Disodium in Treating Patients With Advanced Non-Small Cell Lung Cancer or Other Solid Tumors

Phase 1/2 Completed

27 enrolled 7 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT01443078 2018-08-09

Neoadjuvant Platinum-based Chemotherapy for Patients With Resectable , Non-small Cell Lung Cancer With Switch to Chemotherapy Alternative in Nonresponders (NEOSCAN)

Phase 2 Completed

42 enrolled 7 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00111839 2018-04-06

Effects of Matuzumab in Combination With Pemetrexed for the Treatment of Advanced Lung Cancer

Phase 2 Completed

150 enrolled 10 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00577707 2018-01-10

Erlotinib and Chemotherapy for Patients With Stage IB-IIIA NSCLC With EGFR Mutations (ECON)

Phase 2 Completed

9 enrolled 6 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00703638 2017-11-29

Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors

Phase 1 Completed

BreastGastrointestinalGenitourinaryHead & NeckOther solid neoplasmSarcomaThoracic

Breast Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Mesothelioma, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Colorectal Neoplasms

NCT01344824 2017-10-30

Carboplatin, Pemetrexed Disodium, and Bevacizumab for Patients With Stage III or IV Non-Small Cell Lung Cancer Who Are Light/Never Smokers

Phase 2 Completed

38 enrolled 13 charts

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00248495 2017-07-12

Pemetrexed Disodium and Cisplatin in Treating Patients Who Are Undergoing Surgery for Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer

Phase 2 Completed

38 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00942825 2017-05-24

CBP08-02

Phase 2 Completed

195 enrolled 8 charts

Lung Neoplasms, Neoplasm Metastasis, Pleural Effusion

NCT00227539 2017-05-09

Positron Emission Tomography in Predicting Response in Patients Who Are Undergoing Treatment With Pemetrexed Disodium and Cisplatin With or Without Surgery for Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer

Phase 2 Completed

25 enrolled 8 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00226577 2017-03-23

Pharmacogenomic & Phase II Study of Gemcitabine and Pemetrexed in Non-Small-Cell Lung Cancer.

Phase 2 Completed

52 enrolled 10 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00454194 2017-03-21

Pemetrexed Disodium With or Without Sorafenib as Second-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer

Phase 2 Completed

110 enrolled 15 charts

Adenocarcinoma of Lung, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00227019 2017-03-06

Phase 2 Trial of Bevacizumab in Combination With Pemetrexed

Phase 2 Completed

16 enrolled 9 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasm Metastasis

NCT00508144 2017-02-13

Single Agent Alimta in Poor Performance Status in Non-small Cell Lung Cancer

Phase 2 Completed

64 enrolled 5 charts

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Pericardial Effusion, Pleural Effusion, Malignant