Clinical Trials

Lung Neoplasms, Carcinoma, Small Cell, Small Cell Lung Carcinoma

NCT05800587 2025-04-04

Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer

Phase 2 Recruiting

280 enrolled

Phase 1 Active not recruiting

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Small Cell Lung Carcinoma

NCT04514497 2025-03-06

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

28 enrolled

EndocrineGastrointestinalThoracic

Lung Neoplasms, Neoplasm Metastasis, Pancreatic Neoplasms, Carcinoma, Neuroendocrine, Small Cell Lung Carcinoma

NCT02649673 2023-12-05

LCL161 Plus Topotecan for Patients With Relapsed/Refractory Small Cell Lung Cancer and Select Gynecologic Malignancies

Phase 1 Terminated

34 enrolled

GynecologicThoracic

Lung Neoplasms, Ovarian Neoplasms, Small Cell Lung Carcinoma

NCT02481830 2023-07-27

CheckMate331

569 enrolled 13 charts

Lung Neoplasms

NCT02963090 2023-02-15

Pembrolizumab vs Topotecan in Patients With Small Cell Lung Cancer

Phase 2 Terminated

9 enrolled 11 charts

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00025272 2021-09-09

Combination Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer

14 enrolled

Lung Neoplasms

NCT00547651 2019-11-06

AMR PH GL 2007 CL001 Phase 3 Trial in Patients With Small Cell Lung Cancer After Failure of First-Line Chemotherapy

637 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00287963 2018-05-17

Topotecan and Vinorelbine in Treating Patients With Recurrent Lung Cancer

18 enrolled

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Small Cell Lung Carcinoma

NCT00365547 2017-12-28

Topotecan and Bevacizumab in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer That Did Not Respond to Previous Systemic Chemotherapy

46 enrolled 11 charts

Adenocarcinoma of Lung, Adenocarcinoma, Bronchiolo-Alveolar, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00028925 2016-12-07

Combination Chemotherapy With or Without Filgrastim in Treating Patients With Previously Untreated Extensive-Stage Small Cell Lung Cancer

27 enrolled

Lung Neoplasms

NCT00003812 2016-07-20

Chemotherapy Plus Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

75 enrolled

Lung Neoplasms

NCT00033696 2016-07-19

Combination Chemotherapy and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

65 enrolled

Lung Neoplasms

NCT00003281 2016-07-13

Topotecan and Paclitaxel in Treating Patients With Recurrent or Refractory Small Cell Lung Cancer

84 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00004055 2016-07-13

Topotecan, Paclitaxel, and Filgrastim in Treating Patients With Previously Untreated Extensive-Stage Small Cell Lung Cancer

38 enrolled

Lung Neoplasms

NCT00006012 2016-07-06

Combination Chemotherapy and Radiation Therapy in Treating Patients With Limited-Stage Small Cell Lung Cancer

Phase 1/2 Completed

73 enrolled

Lung Neoplasms, Radiation Injuries, Drug-Related Side Effects and Adverse Reactions

NCT00087048 2016-03-22

Topotecan in Treating Patients With Recurrent Extensive-Stage Small Cell Lung Cancer

Phase 2 Terminated

1 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00466232 2015-12-16

Phase I Study of Weekly Topotecan in Combination With Sorafenib in Treatment of Relapsed Small Cell Lung Cancer

16 enrolled

Lung Neoplasms, Carcinoma, Small Cell

NCT00316186 2015-05-07

First-line Treatment Of Subjects With Extensive Disease Small Cell Lung Cancer With Weekly Hycamtin And Paraplatin

33 enrolled 10 charts

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00006374 2014-01-15

Combination Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Phase 2 Withdrawn

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00003917 2014-01-09

Topotecan in Treating Patients With Relapsed Small Cell Lung Cancer

4 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00041015 2014-01-09

Combination Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer

4 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00003943 2013-04-17

Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Cancer.

3 enrolled

Lung Neoplasms, Neoplasms, Unknown Primary

NCT00276276 2013-04-15

Active Symptom Control Alone Or In Combination With Oral Topotecan In Patients With Relapsed Resistant Small Cell Lung Cancer

141 enrolled

Lung Neoplasms, Recurrence, Small Cell Lung Carcinoma

NCT00004186 2013-04-12

Combination Chemotherapy in Treating Patients With Small Cell Lung Cancer

Phase 1/2 Completed

55 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00004137 2013-02-15

S9914: Combination Chemotherapy Plus Filgrastim in Untreated Extensive-Stage Small Cell Lung Cancer

88 enrolled

Lung Neoplasms

NCT00002537 2013-02-11

Radiation Therapy Plus Topotecan in Treating Patients With Non-small Cell Lung Cancer

20 enrolled

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT00002625 2013-02-11

Topotecan and Radiation Therapy in Treating Patients With Solid Tumors or Lymphoma

DermatologicGastrointestinalLymphoidOther hematologic neoplasmThoracic

5 enrolled

Burkitt Lymphoma, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Hodgkin Disease, Lung Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Small Cell Lung Carcinoma

NCT00305942 2013-01-31

Topotecan and Carboplatin in the First-Line Treatment of Patients With Extensive Stage Small Cell Lung Cancer

61 enrolled 9 charts

Lung Neoplasms, Carcinoma, Small Cell

NCT00294190 2012-12-10

Higher Dose Weekly Topotecan In The Treatment Of Patients With Extensive Stage Small-Cell Lung Cancer

38 enrolled

Lung Neoplasms, Carcinoma, Small Cell, Small Cell Lung Carcinoma

NCT00193388 2010-07-28

Weekly Topotecan in the Second-Line Treatment of Small Cell Lung Cancer

100 enrolled

Lung Neoplasms

NCT00193401 2010-07-28

Weekly Topotecan in the First-line Treatment of Elderly Patients With Small Cell Lung Cancer

40 enrolled

Lung Neoplasms

NCT00388089 2010-06-29

Bortezomib and Topotecan in Treating Patients With Advanced Solid Tumors

24 enrolled

Lung Neoplasms, Small Cell Lung Carcinoma

NCT00193245 2010-06-28

Oral Topotecan Versus Docetaxel in Second-Line Treatment of Non-Small Cell Lung Cancer

80 enrolled

Lung Neoplasms

NCT00322751 2010-01-07

Concurrent Radiotherapy With Weekly Topotecan for Primary Treatment of Inoperable Localized Non-small Cell Lung Cancer

10 enrolled

Lung Neoplasms

NCT00315861 2009-01-23

Topotecan in Combination With Pemetrexed in Patients With Advanced Malignancies

15 enrolled

GynecologicThoracic

Uterine Cervical Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms

NCT00502762 2008-03-12

Topotecan for Irinotecan-Refractory SCLC

Phase 2 Unknown