Announcements Trials
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Phase

Phase 1 2

Status

Completed 2

Sponsor Class

INDUSTRY 2

Study Type

Interventional 2

Sponsor

Cancer Type

Lymphoid 2

Conditions

Lymphoma, Large B-Cell, Diffuse 6Lymphoma, Follicular 5Sarcoma, Synovial 4Sarcoma 4Rhabdoid Tumor 3Mesothelioma 3Lymphoma, Non-Hodgkin 3Lymphoma, B-Cell 3Recurrence 2Lymphoma, Mantle-Cell 2Lymphoma, B-Cell, Marginal Zone 2Lymphoma 2Wilms Tumor 1Tertiary Lymphoid Structures 1Sarcoma, Ewing 1Rhabdomyosarcoma 1Pancreatic Neoplasms 1Osteosarcoma 1Neuroectodermal Tumors, Primitive, Peripheral 1Neuroblastoma 1Medulloblastoma 1Hodgkin Disease 1Histiocytosis, Langerhans-Cell 1Hepatoblastoma 1Hematologic Neoplasms 1Glioma 1Ependymoma 1Colorectal Neoplasms 1Central Nervous System Neoplasms 1

Interventions

Cyclophosphamide 85Rituximab 80Peripheral Blood Stem Cell Transplantation 60fludarabine phosphate 58Filgrastim 40Mycophenolic Acid 37Whole-Body Irradiation 35Cyclosporine 35Radiotherapy 33Etoposide 33Busulfan 33Tacrolimus 31Antilymphocyte Serum 28Melphalan 26Methotrexate 22Prednisone 19Bortezomib 19Methylprednisolone 16Cytarabine 16Vincristine 15Lenalidomide 15Flow Cytometry 14Cord Blood Stem Cell Transplantation 13sargramostim 12Doxorubicin 12Bendamustine Hydrochloride 12fludarabine 11Dexamethasone 11Carmustine 11Carboplatin 11

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Completed × Lymphoma, B-Cell, Marginal Zone × tazemetostat × Clear all
NCT03010982 2024-03-22

Open-Label, Multi-Center, Two-Part, Ph1 Study to Characterize the PKs of an Intravenous Micro-Dose of [14C]-Tazemetostat (EPZ 6438) and the ADME of an Oral [14C]-Labeled Dose of Tazemetostat in Subjects With B-Cell Lymphomas or Adv Solid Tumors

Ipsen

Phase 1 Completed
3 enrolled
Lymphoid

Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell

NCT03028103 2023-06-26

Open-Label, Multicenter, Two-Part, Phase 1 Study to Characterize Effects of a Moderate CYP3A Inhibitor on PK of Tazemetostat, Effects of Tazemetostat on PK of CYP2C8 and CYP2C19 Substrates, and Effect of Increased Gastric pH on PK of Tazemetostat in B-cell Lymphoma or Advanced Solid Tumor Patients

Ipsen

Phase 1 Completed
32 enrolled 30 charts
Lymphoid

Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell

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