NCT06748001 2026-02-09Avapritinib Rollover StudyBlueprint Medicines CorporationPhase 4 Recruiting60 enrolled
NCT03731260 2025-09-23(PIONEER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, Versus Placebo in Patients With Indolent Systemic MastocytosisBlueprint Medicines CorporationPhase 2 Active not recruiting251 enrolled
NCT03580655 2025-04-30(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic MastocytosisBlueprint Medicines CorporationPhase 2 Completed107 enrolled 2 FDA
NCT02561988 2023-03-17(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid MalignanciesBlueprint Medicines CorporationPhase 1 Completed86 enrolled 2 FDA