Clinical Trials

Blastic Plasmacytoid Dendritic Cell Neoplasm, Burkitt Lymphoma, Hodgkin Disease, Leukemia, Hairy Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Hematologic Neoplasms, Mastocytosis, Systemic, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

NCT00769587 2025-09-22

Thalidomide in Treating Patients With Relapsed or Progressive Systemic Mastocytosis

Completed

MyeloidOther neoplasm

Precancerous Conditions, Mastocytosis, Systemic

NCT00449748 2025-05-01

Everolimus (RAD001) as Therapy for Patients With Systemic Mastocytosis

10 enrolled 4 charts

Mastocytosis, Systemic

NCT03580655 2025-04-30

(PATHFINDER) Study to Evaluate Efficacy and Safety of Avapritinib (BLU-285), A Selective KIT Mutation-targeted Tyrosine Kinase Inhibitor, in Patients With Advanced Systemic Mastocytosis

107 enrolled 2 FDA

Leukemia, Mast-Cell, Mastocytosis, Systemic

NCT03770273 2024-12-17

Safety and Efficacy of Subcutaneous Sarilumab in Improving the Quality of Life in People With Indolent Systemic Mastocytosis

21 enrolled 13 charts

CNSDermatologicGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmSarcomaThoracic

Mastocytosis, Systemic

NCT02571036 2023-12-13

A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies

Phase 1 Completed

282 enrolled

Mast Cell Activation Disorders, Carcinoma, Non-Small-Cell Lung, Glioma, Leukemia, Mast-Cell, Melanoma, Neoplasms, Germ Cell and Embryonal, Penile Neoplasms, Sarcoma, Mastocytosis, Systemic, Gastrointestinal Stromal Tumors, Renal Insufficiency

NCT02561988 2023-03-17

(EXPLORER) Study of BLU-285 in Patients With Advanced Systemic Mastocytosis (AdvSM) and Relapsed or Refractory Myeloid Malignancies

Phase 1 Completed

86 enrolled 2 FDA

Leukemia, Mast-Cell, Recurrence, Mastocytosis, Systemic

NCT00109707 2021-06-29

A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malignancies

Phase 1/2 Completed

507 enrolled 16 charts

Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Hypereosinophilic Syndrome, Mastocytosis, Systemic, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00814073 2019-12-03

AB06006

Phase 3 Completed

135 enrolled

Blushing, Mastocytosis, Pruritus, Piebaldism, Mastocytosis, Systemic

NCT02441166 2019-07-15

EvaTryMS

Phase NA Completed

250 enrolled

DermatologicMyeloid

Mastocytosis, Cutaneous, Mastocytosis, Systemic

NCT02808793 2019-03-13

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AK002

Phase 1 Completed

25 enrolled

Mastocytosis, Mastocytosis, Systemic

NCT01807598 2019-01-29

Brentuximab Vedotin in Treating Patients With Advanced Systemic Mastocytosis or Mast Cell Leukemia

10 enrolled 14 charts

Leukemia, Mast-Cell, Mastocytosis, Systemic

NCT00782067 2018-11-15

Efficacy and Safety of Midostaurin in Patients With Aggressive Systemic Mastocytosis or Mast Cell Leukemia

116 enrolled 16 charts

Aggression, Leukemia, Leukemia, Mast-Cell, Mastocytosis, Systemic

NCT00233454 2018-09-20

Phase 2 Midostaurin in Aggressive Systemic Mastocytosis and Mast Cell Leukemia

26 enrolled 12 charts

Aggression, Leukemia, Mast-Cell, Mastocytosis, Systemic

NCT00171912 2017-02-23

Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes

MyeloidOther hematologic neoplasmSarcomaThoracic

38 enrolled

Lung Neoplasms, Leukemia, Myelomonocytic, Chronic, Hypereosinophilic Syndrome, Dermatofibrosarcoma, Mastocytosis, Systemic, Leukemia, Myelomonocytic, Juvenile

NCT02478957 2016-09-29

Treatment of Indolent Systemic Mastocytosis With PA101

41 enrolled

Mastocytosis, Mastocytosis, Systemic

NCT01297777 2016-08-29

Imatinib in KIT-negative Systemic Mastocytosis

Phase 4 Completed

10 enrolled

Mast Cell Activation Disorders, Mastocytosis, Mastocytosis, Systemic

NCT00493129 2012-02-08

Ontak (Denileukin Diftitox) in Patients With Systemic Mastocytosis (SM)

8 enrolled