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Phase

Phase 2 3Phase EARLY_PHASE1 2Phase 4 1Phase 3 1Phase 1 1

Status

Completed 2

Sponsor Class

OTHER 2

Study Type

Interventional 2

Sponsor

Cancer Type

CNS 2

Conditions

Rhabdoid Tumor 2Medulloblastoma 2Ependymoma 2Brain Neoplasms 2Recurrence 1Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 1Precursor Cell Lymphoblastic Leukemia-Lymphoma 1Neurotoxicity Syndromes 1Muscle Invasive Bladder Urothelial Carcinoma 1Lymphoma, T-Cell, Peripheral 1Lymphoma, Mantle-Cell 1Lymphoma, Large B-Cell, Diffuse 1Lymphoma 1Leukemia, Large Granular Lymphocytic 1Central Nervous System Neoplasms 1Burkitt Lymphoma 1

Interventions

etoposide phosphate 2Vincristine 2Methotrexate 2Mesna 2Etoposide 2Cyclophosphamide 2Cisplatin 2ribociclib 1palbociclib 1fimepinostat 1abemaciclib 1Thiotepa 1Therapeutics 1Temozolomide 1Tamoxifen 1Lomustine 1Leucovorin 1Isotretinoin 1Hydrocortisone 1Granulocyte Colony-Stimulating Factor 1Filgrastim 1Donepezil 1Celecoxib 1Carboplatin 1CUDC-907 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Phase EARLY_PHASE1 × Medulloblastoma × Methotrexate × Clear all
NCT02905110 2025-03-25

Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children with Recurrent Posterior Fossa Brain Tumors

The University of Texas Health Science Center, Houston

Phase EARLY_PHASE1 Completed
3 enrolled
CNS

Brain Neoplasms, Ependymoma, Medulloblastoma, Rhabdoid Tumor

NCT01737671 2018-01-19

Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study

M.D. Anderson Cancer Center

Phase EARLY_PHASE1 Completed
7 enrolled
CNS

Brain Neoplasms, Ependymoma, Medulloblastoma, Rhabdoid Tumor

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