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Phase

Phase 1/2 1Phase 1 1

Status

Terminated 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

CNS 1

Conditions

Neuroblastoma 2Glioblastoma 2Recurrence 1Melanoma 1Medulloblastoma 1Gliosarcoma 1Disease Progression 1Central Nervous System Neoplasms 1Brain Neoplasms 1

Interventions

Temozolomide 6Radiotherapy 4Irinotecan 3lutetium Lu 177 dotatate 2Nivolumab 2Carboplatin 2sonidegib 1sodium thiosulfate 1silmitasertib 1poly ICLC 1plerixafor 1olaparib 1gallium Ga 68 dotatate 1etoposide phosphate 1entrectinib 1dinutuximab 1bempegaldesleukin 1adavosertib 1abemaciclib 1Vincristine 1Vascular Endothelial Growth Factor A 1Vaccines 1Triiodothyronine 1TPI-287 1Surgical Procedures, Operative 1Radiation 1Peripheral Blood Stem Cell Transplantation 1N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl-6-(5-((methylsulfonyl)ethyl)aminomethyl)-2-furyl)-4-quinazolinamine 1Microarray Analysis 1Melphalan 1

Date Range

30 days90 days1 yearAll

Options

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Clinical Trials

1 trials
RecentStart dateEnrollment
Phase 1/2 × Medulloblastoma × TPI-287 × Clear all
NCT01483820 2024-08-06

Safety and Efficacy Study of TPI-287 in Neuroblastoma and Medulloblastoma

Milton S. Hershey Medical Center

Phase 1/2 Terminated
8 enrolled 9 charts
CNS

Medulloblastoma, Neuroblastoma

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