Announcements Trials
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Phase

Phase 1/2 1Phase 1 1

Status

Completed 18Recruiting 5Active not recruiting 4Terminated 2Not yet recruiting 2Withdrawn 1Unknown 1

Sponsor Class

OTHER 1INDUSTRY 1

Study Type

Interventional 2

Sponsor

Cancer Type

CNS 2Sarcoma 1

Conditions

Glioblastoma 52Brain Neoplasms 28Glioma 22Gliosarcoma 19Melanoma 18Astrocytoma 17Central Nervous System Neoplasms 11Oligodendroglioma 10Neoplasms 9Neoplasm Metastasis 8Recurrence 6Carcinoma, Non-Small-Cell Lung 5Neuroblastoma 4Lymphoma 4Ependymoma 4Diffuse Intrinsic Pontine Glioma 3Breast Neoplasms 3Sarcoma, Ewing 2Neurologic Manifestations 2Neuroectodermal Tumors, Primitive 2Neoplasms, Second Primary 2Meningeal Carcinomatosis 2Medulloblastoma 2Bone Neoplasms 2Urinary Bladder Neoplasms 1Thrombocytopenia 1Tetanus 1Spinal Cord Neoplasms 1Solid Tumors 1Small Cell Lung Cancer Recurrent 1

Interventions

Filgrastim 4Cyclophosphamide 4Vincristine 3Topotecan 3Melphalan 3Lomustine 3Granulocyte Colony-Stimulating Factor 3Cisplatin 3etoposide phosphate 2Thiotepa 2Temozolomide 2Radiotherapy 2Mesna 2Ifosfamide 2Etoposide 2Carboplatin 2Busulfan 2sonidegib 1sodium thiosulfate 1silmitasertib 1sargramostim 1ribociclib 1poly ICLC 1palbociclib 1omburtamab I-131 1gadobutrol 1gadobenic acid 1bempegaldesleukin 1Yoga 1Vaccines 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Terminated × Medulloblastoma × Temozolomide × Clear all
NCT05429502 2025-10-10

Study of Efficacy and Safety of Ribociclib (LEE011) in Combination With Topotecan and Temozolomide (TOTEM) in Pediatric Patients With Relapsed or Refractory Neuroblastoma and Other Solid Tumors

Novartis

Phase 1 Terminated
12 enrolled
CNSSarcoma

Glioma, Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma

NCT01601184 2019-05-21

Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway

Centre Leon Berard

Phase 1/2 Terminated
24 enrolled
CNS

Microphthalmia, Isolated, with Coloboma 5, Medulloblastoma

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