Clinical Trials

Phase 1/2 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Ependymoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Central Nervous System Neoplasms

NCT02650401 2026-03-25

STARTRK-NG

69 enrolled 2 FDA

CNSEndocrineGenitourinaryHead & NeckSarcoma

Thyroid Cancer, Papillary, Brain Neoplasms, Glioma, Medulloblastoma, Neoplasm Metastasis, Wilms Tumor, Neuroblastoma, Recurrence, Salivary Gland Neoplasms, Sarcoma, Sarcoma, Ewing, Central Nervous System Neoplasms, Nephroma, Mesoblastic

NCT06161519 2026-03-19

PLX038 in Primary Central Nervous System Tumors Containing MYC or MYCN Amplifications

Phase 1/2 Recruiting

146 enrolled

Phase 1/2 Not yet recruiting

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Recurrence

NCT06639607 2026-03-10

PRiME II

68 enrolled

Diffuse Intrinsic Pontine Glioma, Ependymoma, Medulloblastoma, Recurrence

NCT04238819 2026-03-02

A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma

47 enrolled 36 charts

Phase 1/2 Not yet recruiting

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT07346157 2026-01-16

PNOC044

69 enrolled

Medulloblastoma

NCT03904862 2025-10-30

Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery

21 enrolled

Phase 1/2 Active not recruiting

Microphthalmia, Isolated, with Coloboma 5, Medulloblastoma

NCT04758533 2024-12-27

AloCELYVIR

13 enrolled

Diffuse Intrinsic Pontine Glioma, Medulloblastoma, Recurrence

NCT01483820 2024-08-06

Safety and Efficacy Study of TPI-287 in Neuroblastoma and Medulloblastoma

8 enrolled 9 charts

Phase 1/2 Not yet recruiting

Medulloblastoma, Neuroblastoma

NCT06485908 2024-07-03

MEPENDAX

40 enrolled

Ependymoma, Medulloblastoma

NCT04167618 2023-10-06

177Lu-DTPA-Omburtamab Radioimmunotherapy for Recurrent or Refractory Medulloblastoma

2 enrolled 9 charts

Medulloblastoma

NCT02095132 2023-09-26

Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors

76 enrolled 25 charts

Medulloblastoma, Neuroblastoma, Pinealoma, Rhabdomyosarcoma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive

NCT00788125 2023-07-14

Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors

CNSGastrointestinalGenitourinaryGynecologicLymphoidSarcoma

7 enrolled 9 charts

Familial ependymoma, Ovarian Germ Cell Cancer, Testicular Germ Cell Tumor, Astrocytoma, Burkitt Lymphoma, Carcinoma, Renal Cell, Immunoblastic Lymphadenopathy, Kidney Neoplasms, Liver Neoplasms, Lymphoma, Medulloblastoma, Wilms Tumor, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Recurrence, Sarcoma, Osteosarcoma, Spinal Cord Neoplasms, Teratoma, Testicular Neoplasms, Lymphoma, Large B-Cell, Diffuse, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Lymphoma, Large-Cell, Anaplastic, Nephroma, Mesoblastic, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor, Optic Nerve Glioma, Lymphoma, Extranodal NK-T-Cell, Dendritic Cell Sarcoma, Interdigitating

NCT04730349 2023-03-24

PIVOT IO 020

CNSDermatologicLymphoidOther hematologic neoplasmSarcoma

15 enrolled 14 charts

Ependymoma, Glioma, Leukemia, Lymphoma, Lymphoma, Non-Hodgkin, Medulloblastoma, Melanoma, Neoplasms, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Leukemia, B-Cell

NCT00983398 2021-10-26

Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors

Phase 1/2 Unknown

17 enrolled

Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Neuroectodermal Tumors, Primitive

NCT01619865 2021-07-27

GA-68

223 enrolled 11 charts

CNSEndocrineNET

Carcinoid Tumor, Medulloblastoma, Neuroblastoma, Neuroendocrine Tumors

NCT01614132 2020-03-31

NOA-07

33 enrolled

Medulloblastoma, Neoplasms, Neuroectodermal Tumors

NCT01601184 2019-05-21

Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway

24 enrolled

Microphthalmia, Isolated, with Coloboma 5, Medulloblastoma

NCT01977677 2018-10-23

Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma

30 enrolled 11 charts

Glioblastoma, Glioma, Medulloblastoma, Pinealoma, Neuroectodermal Tumors, Primitive, Gliosarcoma

NCT02332889 2018-05-04

Phase I/II: Decitabine/Vaccine Therapy in Relapsed/Refractory Pediatric High Grade Gliomas/Medulloblastomas/CNS PNETs

1 enrolled 6 charts

Glioma, Medulloblastoma, Neuroectodermal Tumors, Primitive

NCT01125800 2017-03-20

A Phase I Dose Finding and Safety Study of Oral LDE225 in Children and a Phase II Portion to Assess Preliminary Efficacy in Recurrent or Refractory MB

CNSGastrointestinalSarcoma

76 enrolled 18 charts

Astrocytoma, Glioma, Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Hepatoblastoma

NCT00003461 2014-08-21

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasm Metastasis, Neuroblastoma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00002752 2014-07-16

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers

Familial ependymoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Neoplasm Metastasis, Oligodendroglioma, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT00095940 2014-05-23

Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors

52 enrolled 17 charts

Familial ependymoma, Astrocytoma, Glioblastoma, Medulloblastoma, Oligodendroglioma

NCT00005952 2013-06-20

Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors

CNSGenitourinaryGynecologicHead & NeckSarcoma

30 enrolled

Familial ependymoma, Testicular Germ Cell Tumor, Astrocytoma, Head and Neck Neoplasms, Kidney Neoplasms, Medulloblastoma, Nasopharyngeal Neoplasms, Wilms Tumor, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Sarcoma, Testicular Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Optic Nerve Glioma

NCT00003478 2013-02-20

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors

10 enrolled