Announcements Trials
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Phase

Phase 1 72Phase 2 45Phase 1/2 11Phase NA 10Phase 3 7Phase EARLY_PHASE1 4Phase 2/3 1

Status

Completed 4Recruiting 2Terminated 1Not yet recruiting 1Active not recruiting 1

Sponsor Class

OTHER 4

Study Type

Interventional 4

Sponsor

Cancer Type

CNS 4

Conditions

Breast Neoplasms 97Prostatic Neoplasms 41Neoplasms 40Glioblastoma 26Melanoma 24Head and Neck Neoplasms 24Brain Neoplasms 24Ovarian Neoplasms 18Squamous Cell Carcinoma of Head and Neck 17Lung Neoplasms 17Carcinoma, Renal Cell 17Carcinoma, Hepatocellular 17Glioma 16Pancreatic Neoplasms 15Carcinoma, Non-Small-Cell Lung 15Leukemia, Myeloid, Acute 14Colorectal Neoplasms 14Precursor Cell Lymphoblastic Leukemia-Lymphoma 11Urinary Bladder Neoplasms 10Lymphoma 10Uterine Cervical Neoplasms 9Polycystic Ovary Syndrome 9Lymphoma, Non-Hodgkin 9Fallopian Tube Neoplasms 9Endometrial Neoplasms 9Myelodysplastic Syndromes 8Multiple Myeloma 8Lymphoma, Mantle-Cell 8Lymphoma, Large B-Cell, Diffuse 8Skin Neoplasms 7

Interventions

Methotrexate 2etoposide phosphate 1Therapeutics 1Leucovorin 1Etoposide 1Donepezil 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Phase EARLY_PHASE1 × Completed × Medulloblastoma × Clear all
NCT02905110 2025-03-25

Methotrexate and Etoposide Infusions Into the Fourth Ventricle in Children with Recurrent Posterior Fossa Brain Tumors

The University of Texas Health Science Center, Houston

Phase EARLY_PHASE1 Completed
3 enrolled
CNS

Brain Neoplasms, Ependymoma, Medulloblastoma, Rhabdoid Tumor

NCT04315064 2025-03-10

Infusion of Panobinostat (MTX110) Into the Fourth Ventricle in Children and Adults with Recurrent Medulloblastoma

The University of Texas Health Science Center, Houston

Phase EARLY_PHASE1 Completed
2 enrolled
CNS

Brain Neoplasms, Medulloblastoma

NCT00452868 2018-09-07

Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain

Wake Forest University Health Sciences

Phase EARLY_PHASE1 Completed
14 enrolled 7 charts
CNS

Familial ependymoma, Astrocytoma, Medulloblastoma, Radiation Injuries, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neurotoxicity Syndromes, Optic Nerve Glioma

NCT01737671 2018-01-19

Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot Study

M.D. Anderson Cancer Center

Phase EARLY_PHASE1 Completed
7 enrolled
CNS

Brain Neoplasms, Ependymoma, Medulloblastoma, Rhabdoid Tumor

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