Clinical Trials

10 enrolled

CNSDermatologic

Brain Neoplasms, Melanoma

NCT05136196 2026-06-05

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

150 enrolled

DermatologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Melanoma, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05355701 2026-06-05

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

CNSDermatologicHead & NeckThoracic

267 enrolled

Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Thyroid Neoplasms

NCT05538130 2026-06-05

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

CNSDermatologicHead & NeckThoracic

124 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Neoplasms, Thyroid Neoplasms

NCT07527325 2026-06-05

Fianlimab&Cemiplimab as TotalNeoadj The (TNT) ForMelanoma

Phase 2 Not yet recruiting

35 enrolled

Phase NA Not yet recruiting

Melanoma

NCT07621614 2026-06-05

A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information

51 enrolled

Phase EARLY_PHASE1 Recruiting

Melanoma

NCT07628634 2026-06-05

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

25 enrolled

CNSDermatologicGenitourinaryLymphoidSarcoma

Adenocarcinoma, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Endocrine Gland Neoplasms, Glioma, Leiomyosarcoma, Lymphoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Carcinoma, Ductal

NCT07628894 2026-06-05

Circadian-Optimized Light Therapy for the Treatment of Patients With Advanced Melanoma Receiving Tumor-Infiltrating Lymphocyte Therapy

Phase 1 Not yet recruiting

8 enrolled

Phase 1 Active not recruiting

Melanoma

NCT03132922 2026-06-04

MAGE-A4ᶜ¹º³²T for Multi-Tumor

71 enrolled 20 charts

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Adenocarcinoma, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Melanoma, Neoplasm Metastasis, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms, Sarcoma, Synovial, Liposarcoma, Myxoid

NCT04458259 2026-06-04

Study of PF-07265807 in Participants With Metastatic Solid Tumors.

Phase 1 Terminated

88 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicThoracic

Parkinson Disease 4, Autosomal Dominant Lewy Body, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Small Cell Lung Carcinoma

NCT04598009 2026-06-04

Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma

25 enrolled

Melanoma

NCT04895709 2026-06-04

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

BreastDermatologicGenitourinaryGynecologicHead & NeckThoracic

1,109 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Melanoma, Ovarian Neoplasms, Triple Negative Breast Neoplasms

NCT04955743 2026-06-04

Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma

Phase 2 Terminated

18 enrolled 13 charts

CNSDermatologicGenitourinary

Brain Neoplasms, Carcinoma, Renal Cell, Melanoma

NCT06066138 2026-06-04

A Study of Therapeutic Drug Monitoring-Based Atezolizumab Dosing

DermatologicGastrointestinalSarcomaThoracic

30 enrolled

Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular, Melanoma, Sarcoma, Alveolar Soft Part, Small Cell Lung Carcinoma

NCT06319196 2026-06-04

ClearMe

54 enrolled

Melanoma

NCT07237594 2026-06-04

REPLAY

4 enrolled

Melanoma

NCT07627698 2026-06-04

DUET-MEL

36 enrolled

Uveal Melanoma, Melanoma

NCT01009177 2026-06-03

Effect of Bosentan in Patients With Metastatic Melanoma Treated With Dacarbazine (DTIC)

Phase 2 Completed

80 enrolled

Melanoma, Neoplasm Metastasis

NCT02465060 2026-06-03

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther hematologic neoplasmPlasma cellThoracic

6,452 enrolled 1 FDA

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Glioma, Carcinoma, Hepatocellular, Lung Neoplasms, Lymphoma, Melanoma, Multiple Myeloma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Uterine Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Hematologic Neoplasms

NCT03958383 2026-06-03

IT-hu14.18-IL2 With Radiation, Nivolumab and Ipilimumab for Melanoma

Phase 1/2 Terminated

8 enrolled 12 charts

Melanoma

NCT05625399 2026-06-03

RELATIVITY-127

579 enrolled

DermatologicHead & NeckThoracic

Melanoma

NCT06897735 2026-06-03

EDDIS-a1

Phase 1 Terminated

4 enrolled

Lung Neoplasms, Melanoma, Mouth Neoplasms

NCT04083599 2026-06-02

GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors

Phase 1/2 Active not recruiting

350 enrolled

DermatologicGastrointestinalHead & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Melanoma, Colorectal Neoplasms

NCT06984328 2026-06-02

Study of the Effectiveness and Safety of Acasunlimab Alone and With Pembrolizumab to Treat Advanced Melanoma of the Skin That Has Returned After Treatment With an Approved Checkpoint Inhibitor Therapy (ABBIL1TY MELANOMA-07)

1 enrolled

Phase 2 Not yet recruiting

Melanoma, Recurrence

NCT07619898 2026-06-02

PHOENIX-ECP

112 enrolled

Colitis, Hepatitis, Melanoma

NCT02332668 2026-06-01

MK-3475-051

370 enrolled

DermatologicLymphoid

Lymphoma, Melanoma

NCT03467516 2026-06-01

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Metastatic Uveal Melanoma

34 enrolled

Uveal Melanoma, Melanoma, Uveal Diseases, Uveal Neoplasms

NCT04168528 2026-06-01

Phase I/IIa Study of 68GaNOTA-Anti-MMR-VHH2 for PET/CT

Phase 1/2 Terminated

13 enrolled

BreastDermatologic

Breast Neoplasms, Melanoma

NCT05039801 2026-06-01

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

DermatologicGynecologicHead & NeckSarcoma

54 enrolled

Squamous Cell Carcinoma of Head and Neck, Chondrosarcoma, Melanoma, Ovarian Neoplasms, Endometrial Neoplasms

NCT05542342 2026-06-01

SITISVEAL

Phase 2 Completed

16 enrolled 14 charts

Melanoma

NCT05912244 2026-06-01

A Study of IO102/IO103, Nivolumab, and Relatlimab in People With Melanoma

43 enrolled

Melanoma

NCT00937937 2026-05-29

Dinaciclib in Treating Patients With Stage IV Melanoma

72 enrolled 14 charts

Melanoma

NCT01134614 2026-05-29

Ipilimumab With or Without Sargramostim in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery

245 enrolled 8 charts

Melanoma

NCT01274338 2026-05-29

Ipilimumab or High-Dose Interferon Alfa-2b in Treating Patients With High-Risk Stage III-IV Melanoma That Has Been Removed by Surgery

1,673 enrolled 19 charts

Melanoma

NCT01708941 2026-05-29

Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

88 enrolled 14 charts

Melanoma

NCT02073123 2026-05-29

Study of IDO Inhibitor in Combination With Checkpoint Inhibitors for Adult Patients With Metastatic Melanoma

Phase 1/2 Completed

131 enrolled 23 charts

Melanoma

NCT02196181 2026-05-29

Testing Two Different Treatment Schedules of Dabrafenib and Trametinib for Skin Cancer Which Has Spread

280 enrolled

Melanoma

NCT02224781 2026-05-29

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

267 enrolled 8 charts

Phase 2/3 Active not recruiting

Melanoma

NCT02339571 2026-05-29

A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma

600 enrolled

Melanoma

NCT02645149 2026-05-29

Match Mel

Phase 2 Completed

216 enrolled

BreastDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Melanoma

NCT03289962 2026-05-29

A Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors

Phase 1 Completed

273 enrolled

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Kidney Neoplasms, Melanoma, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT04221438 2026-05-29

Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement

Phase 2 Terminated

3 enrolled 11 charts

Lymphatic Metastasis, Melanoma

NCT05155033 2026-05-29

Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma

DermatologicGenitourinary

78 enrolled

Carcinoma, Renal Cell, Melanoma

NCT06171178 2026-05-29

A Study of ASP1012 in Adults With Solid Tumors

Phase 1 Terminated

15 enrolled

Melanoma

NCT07281924 2026-05-29

Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis

15 enrolled

Phase 2 Not yet recruiting

Melanoma

NCT07492680 2026-05-29

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

260 enrolled

CNSDermatologicGastrointestinal

Brain Neoplasms, Melanoma, Pancreatic Neoplasms

NCT07615881 2026-05-29

IpiD

Phase 1/2 Not yet recruiting

18 enrolled

Melanoma

NCT02506153 2026-05-28

Physician/Patient Choice of Either High-Dose Recombinant Interferon Alfa-2B or Ipilimumab, Versus Pembrolizumab in Treating Patients With Stage III-IV High Risk Melanoma That Has Been Removed by Surgery

1,301 enrolled 16 charts

Melanoma

NCT04305054 2026-05-28

KEYMAKER-U02

Phase 1/2 Completed

335 enrolled