Announcements Trials
Browse Landscape

Phase

Phase 2 31Phase 1 20Phase 1/2 10Phase 3 8Phase 4 1

Status

Completed 5Active not recruiting 2Terminated 1

Sponsor Class

INDUSTRY 7NIH 1

Study Type

Interventional 8

Sponsor

Cancer Type

Dermatologic 8

Conditions

Melanoma 8Neoplasms 3Skin Neoplasms 1Sarcoma 1Refractory Differentiated Thyroid Gland Carcinoma 1Neoplasm Metastasis 1Fever 1Differentiated Thyroid Cancer (DTC) 1

Interventions

Dacarbazine 25Nivolumab 24pembrolizumab 19Ipilimumab 18Interferon-alpha 10trametinib 8Vemurafenib 8dabrafenib 7aldesleukin 7Temozolomide 7Introns 7Interferon alpha-2 6Interleukin-2 5Cisplatin 5Chemotherapy, Adjuvant 5talimogene laherparepvec 4cemiplimab 4binimetinib 4Radiotherapy 4Paclitaxel 4Granulocyte-Macrophage Colony-Stimulating Factor 4sargramostim 3encorafenib 3cobimetinib 3Vinblastine 3Surgical Procedures, Operative 3Specimen Handling 3Sodium Chloride 3Radiosurgery 3Opdualag 3

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

8 trials
RecentStart dateEnrollment
Phase 3 × Melanoma × trametinib × Clear all
NCT01682083 2026-04-21

COMBI-AD

Novartis

Phase 3 Completed
870 enrolled 15 charts 1 FDA
Dermatologic

Melanoma, Neoplasms

NCT06346067 2026-02-27

A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)

Erasca, Inc.

Phase 3 Active not recruiting
78 enrolled
Dermatologic

Melanoma

NCT02224781 2026-02-18

Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma

National Cancer Institute (NCI)

Phase 3 Active not recruiting
267 enrolled 8 charts
Dermatologic

Melanoma

NCT02967692 2025-09-18

COMBI-i

Novartis

Phase 3 Terminated
568 enrolled 28 charts
Dermatologic

Melanoma, Skin Neoplasms

NCT03551626 2025-04-29

COMBI-APlus

Novartis

Phase 3 Completed
552 enrolled 12 charts
Dermatologic

Fever, Melanoma

NCT01597908 2021-02-24

COMBI-v

Novartis

Phase 3 Completed
704 enrolled 13 charts
Dermatologic

Melanoma, Neoplasms

NCT01584648 2021-02-17

A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma

Novartis

Phase 3 Completed
423 enrolled 15 charts
Dermatologic

Melanoma

NCT01245062 2018-04-05

GSK1120212 vs Chemotherapy in Advanced or Metastatic BRAF V600E/K Mutation-positive Melanoma

GlaxoSmithKline

Phase 3 Completed
322 enrolled 24 charts
Dermatologic

Melanoma, Neoplasms

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