Announcements Trials
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Phase

Phase 1/2 2Phase 1 2

Status

Active not recruiting 2Recruiting 1Not yet recruiting 1

Sponsor Class

OTHER 3NIH 1

Study Type

Interventional 4

Sponsor

Cancer Type

CNS 4Gastrointestinal 1Breast 1

Conditions

Glioblastoma 50Breast Neoplasms 50Carcinoma, Non-Small-Cell Lung 48Prostatic Neoplasms 47Squamous Cell Carcinoma of Head and Neck 37Lung Neoplasms 30Head and Neck Neoplasms 26Glioma 23Rectal Neoplasms 22Sarcoma 20Neoplasms 20Brain Neoplasms 20Oropharyngeal Neoplasms 16Esophageal Neoplasms 15Uterine Cervical Neoplasms 14Neoplasm Metastasis 14Astrocytoma 14Esophageal Squamous Cell Carcinoma 13Triple Negative Breast Neoplasms 12Carcinoma, Hepatocellular 12Pancreatic Neoplasms 11Melanoma 11Gliosarcoma 10Colorectal Neoplasms 10Stomach Neoplasms 9Small Cell Lung Carcinoma 9Lymphoma 9Hodgkin Disease 9Carcinoma, Squamous Cell 9Urinary Bladder Neoplasms 8

Interventions

Pemetrexed 8Spinal Puncture 5Specimen Handling 4Radiotherapy 4Magnetic Resonance Spectroscopy 4aflutinib 3Trastuzumab 3Bevacizumab 3trastuzumab deruxtecan 2pembrolizumab 2osimertinib 2Radiotherapy, Intensity-Modulated 2tucatinib 1toripalimab 1sintilimab 1sacituzumab govitecan 1pertuzumab 1peginterferon alfa-2b 1lorlatinib 1lenvatinib 1azeliragon 1avelumab 1adavosertib 1Temozolomide 1Referral and Consultation 1Radiosurgery 1Radiation 1Probability 1Physical Examination 1Nivolumab 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Meningeal Carcinomatosis × Radiotherapy × 1 year × Clear all
NCT04588545 2026-05-26

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

H. Lee Moffitt Cancer Center and Research Institute

Phase 1/2 Active not recruiting
33 enrolled
CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT06431685 2026-05-08

Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer

Sichuan University

Phase 1 Recruiting
10 enrolled
CNS

Meningeal Carcinomatosis

NCT04460937 2026-04-29

Testing the Addition of an Anti-cancer Drug, Adavosertib, to Radiation Therapy for Patients With Incurable Esophageal and Gastroesophageal Junction Cancers

National Cancer Institute (NCI)

Phase 1 Active not recruiting
4 enrolled 9 charts
CNSGastrointestinal

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Brain Neoplasms, Meningeal Carcinomatosis

NCT07177950 2025-09-17

A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases

Peking University Cancer Hospital & Institute

Phase 1/2 Not yet recruiting
51 enrolled
BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

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