Announcements Trials
Browse Landscape

Phase

Phase NA 2Phase 2 2Phase 3 1

Status

Recruiting 4Completed 1

Sponsor Class

OTHER 5

Study Type

Interventional 5

Sponsor

Cancer Type

CNS 5Breast 5Thoracic 4

Conditions

Burkitt Lymphoma 12Precursor Cell Lymphoblastic Leukemia-Lymphoma 7Lung Neoplasms 6Breast Neoplasms 6Meningeal Carcinomatosis 5Leukemia, Myeloid, Acute 5Carcinoma, Non-Small-Cell Lung 5Lymphoma, Large B-Cell, Diffuse 4Leukemia, Biphenotypic, Acute 4Myelodysplastic Syndromes 3Glioblastoma 3Astrocytoma 3Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 2Precursor B-Cell Lymphoblastic Leukemia-Lymphoma 2Lymphoma 2Glioma 2Brain Neoplasms 2Uveal Melanoma 1Rhabdomyosarcoma 1Oligodendroglioma 1Nevus 1Neoplastic Cells, Circulating 1Neoplasm Recurrence, Local 1Multiple Myeloma 1Meningioma 1Meningeal Neoplasms 1Melanoma 1Medulloblastoma 1Lymphoma, T-Cell, Peripheral 1Lymphoma, T-Cell, Cutaneous 1

Interventions

Pemetrexed 8Spinal Puncture 5Specimen Handling 4Radiotherapy 4Magnetic Resonance Spectroscopy 4aflutinib 3Trastuzumab 3Bevacizumab 3trastuzumab deruxtecan 2pembrolizumab 2osimertinib 2Radiotherapy, Intensity-Modulated 2tucatinib 1toripalimab 1sintilimab 1sacituzumab govitecan 1pertuzumab 1peginterferon alfa-2b 1lorlatinib 1lenvatinib 1azeliragon 1avelumab 1adavosertib 1Temozolomide 1Referral and Consultation 1Radiosurgery 1Radiation 1Probability 1Physical Examination 1Nivolumab 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Meningeal Carcinomatosis × Spinal Puncture × 1 year × Clear all
NCT06500481 2026-05-07

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

NRG Oncology

Phase 3 Recruiting
115 enrolled
BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT05746325 2026-04-02

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Mayo Clinic

Phase NA Recruiting
5 enrolled
BreastCNSThoracic

Breast Neoplasms, Lung Neoplasms, Meningeal Carcinomatosis

NCT05286684 2026-03-18

Exo-LCR

Centre Oscar Lambret

Phase NA Completed
7 enrolled
BreastCNS

Breast Neoplasms, Meningeal Carcinomatosis

NCT06518057 2025-12-11

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

University of Washington

Phase 2 Recruiting
22 enrolled
BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT06910761 2025-12-08

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

City of Hope Medical Center

Phase 2 Recruiting
35 enrolled
BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

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