Announcements Trials
Browse Landscape

Phase

Phase 1/2 2Phase 1 2Phase 3 1

Status

Active not recruiting 2

Sponsor Class

OTHER 2

Study Type

Interventional 2

Sponsor

Cancer Type

CNS 2

Conditions

Carcinoma, Non-Small-Cell Lung 61Neoplasms 35Colorectal Neoplasms 32Neoplasm Metastasis 31Breast Neoplasms 30Prostatic Neoplasms 26Pancreatic Neoplasms 26Ovarian Neoplasms 26Recurrence 25Multiple Myeloma 25Melanoma 23Squamous Cell Carcinoma of Head and Neck 22Precursor Cell Lymphoblastic Leukemia-Lymphoma 18Triple Negative Breast Neoplasms 17Endometrial Neoplasms 17Lymphoma, Large B-Cell, Diffuse 16Lung Neoplasms 16Glioblastoma 16Lymphoma, Non-Hodgkin 15Leukemia, Myeloid, Acute 14Burkitt Lymphoma 14Stomach Neoplasms 13Small Cell Lung Carcinoma 12Colonic Neoplasms 12Carcinoma, Renal Cell 12Uterine Cervical Neoplasms 11Lymphoma 11Glioma 11Gastrointestinal Neoplasms 11Lymphoma, Follicular 10

Interventions

toripalimab 1pertuzumab 1Trastuzumab 1Radiotherapy 1Pemetrexed 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Phase 1/2 × Meningeal Carcinomatosis × 30 days × Clear all
NCT04588545 2026-05-26

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

H. Lee Moffitt Cancer Center and Research Institute

Phase 1/2 Active not recruiting
33 enrolled
CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT06462222 2026-05-11

Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors

Guangzhou Medical University

Phase 1/2 Active not recruiting
45 enrolled
CNS

Meningeal Carcinomatosis

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