Announcements Trials
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Phase

Phase 1/2 3Phase 1 3Phase NA 1Phase 2 1

Status

Not yet recruiting 1Completed 1Active not recruiting 1

Sponsor Class

OTHER 3

Study Type

Interventional 3

Sponsor

Cancer Type

CNS 3Breast 1

Conditions

Glioblastoma 30Carcinoma, Non-Small-Cell Lung 30Lung Neoplasms 23Head and Neck Neoplasms 21Squamous Cell Carcinoma of Head and Neck 15Lymphoma 15Gliosarcoma 15Central Nervous System Neoplasms 14Sarcoma 12Esophageal Neoplasms 12Rectal Neoplasms 10Glioma 10Leukemia 9Breast Neoplasms 9Brain Neoplasms 9Prostatic Neoplasms 8Pancreatic Neoplasms 8Lymphoma, Follicular 7Esophageal Squamous Cell Carcinoma 7Neoplasms 6Melanoma 6Leukemia, Lymphocytic, Chronic, B-Cell 6Uterine Cervical Neoplasms 5Precursor Cell Lymphoblastic Leukemia-Lymphoma 5Neoplasm Metastasis 5Lymphoma, Large B-Cell, Diffuse 5Lymphoma, B-Cell, Marginal Zone 5Colorectal Neoplasms 5Carcinoma, Renal Cell 5Astrocytoma 5

Interventions

Pemetrexed 7Radiotherapy 3Trastuzumab 2Dexamethasone 2toripalimab 1sacituzumab govitecan 1pertuzumab 1Vitamin B 12 1Rituximab 1Folic Acid 1Bevacizumab 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
Phase 1/2 × Meningeal Carcinomatosis × Radiotherapy × Clear all
NCT04588545 2026-05-26

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

H. Lee Moffitt Cancer Center and Research Institute

Phase 1/2 Active not recruiting
33 enrolled
CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT07177950 2025-09-17

A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases

Peking University Cancer Hospital & Institute

Phase 1/2 Not yet recruiting
51 enrolled
BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Carcinomatosis

NCT03507244 2019-12-26

Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors

The First Hospital of Jilin University

Phase 1/2 Completed
34 enrolled
CNS

Meningeal Carcinomatosis

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