Announcements Trials
Browse Landscape

Phase

Phase 2 2Phase NA 1Phase 3 1

Status

Recruiting 4Withdrawn 1

Sponsor Class

OTHER 4

Study Type

Interventional 4

Sponsor

Cancer Type

Thoracic 4CNS 4Breast 4

Conditions

Prostatic Neoplasms 42Lung Neoplasms 39Leukemia, Myeloid, Acute 38Carcinoma, Non-Small-Cell Lung 33Neoplasm Metastasis 29Breast Neoplasms 27Myelodysplastic Syndromes 21Lymphoma, Large B-Cell, Diffuse 20Leukemia, Lymphocytic, Chronic, B-Cell 19Colorectal Neoplasms 18Pancreatic Neoplasms 17Precursor Cell Lymphoblastic Leukemia-Lymphoma 16Triple Negative Breast Neoplasms 15Multiple Myeloma 15Ovarian Neoplasms 14Glioblastoma 14Squamous Cell Carcinoma of Head and Neck 13Carcinoma, Renal Cell 13Burkitt Lymphoma 13Urinary Bladder Neoplasms 10Mouth Neoplasms 10Melanoma 10Lymphoma, Mantle-Cell 10Endometrial Neoplasms 10Carcinoma, Hepatocellular 10Carcinoma 10Oropharyngeal Neoplasms 9Leukemia, Myelomonocytic, Chronic 9Laryngeal Neoplasms 9Brain Neoplasms 9

Interventions

Pemetrexed 11Spinal Puncture 5Specimen Handling 4Magnetic Resonance Spectroscopy 4Bevacizumab 4aflutinib 3Radiotherapy, Intensity-Modulated 2tucatinib 1trastuzumab deruxtecan 1sintilimab 1sacituzumab govitecan 1osimertinib 1Trastuzumab 1Temozolomide 1Radiotherapy 1Radiosurgery 1Physical Examination 1Phlebotomy 1Immune Checkpoint Inhibitors 1Drug Therapy 1Deferoxamine 1Craniospinal Irradiation 1Capecitabine 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Recruiting × Meningeal Carcinomatosis × Specimen Handling × Clear all
NCT06500481 2026-05-07

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

NRG Oncology

Phase 3 Recruiting
115 enrolled
BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT05746325 2026-04-02

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Mayo Clinic

Phase NA Recruiting
5 enrolled
BreastCNSThoracic

Breast Neoplasms, Lung Neoplasms, Meningeal Carcinomatosis

NCT06518057 2025-12-11

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

University of Washington

Phase 2 Recruiting
22 enrolled
BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT06910761 2025-12-08

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

City of Hope Medical Center

Phase 2 Recruiting
35 enrolled
BreastCNSThoracic

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

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