Announcements Trials
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Phase

Phase 1 1

Status

Completed 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

CNS 1

Conditions

Neoplasms 10Carcinoma, Non-Small-Cell Lung 7Ovarian Neoplasms 6Carcinoma, Transitional Cell 6Squamous Cell Carcinoma of Head and Neck 5Neoplasm Metastasis 5Carcinoma, Renal Cell 5Breast Neoplasms 4Triple Negative Breast Neoplasms 3Recurrence 3Melanoma 3Colorectal Neoplasms 3Urinary Bladder Neoplasms 2Sarcoma 2Lymphoma, Follicular 2Lymphoma 2Central Nervous System Neoplasms 2Uveal Melanoma 1Urethral Neoplasms 1Ureteral Neoplasms 1Solid Tumors 1Skin Neoplasms 1Sezary Syndrome 1Prostatic Neoplasms 1Primary Myelofibrosis 1Peritoneal Neoplasms 1Pancreatic Neoplasms 1Mycosis Fungoides 1Metastatic Urothelial Cell Cancer 1Metastatic Solid Tumors 1

Interventions

Topotecan 3Radiotherapy 3Pemetrexed 3osimertinib 2WP 744 2Radiation 2Busulfan 2AZD3759 2tipifarnib 1sintilimab 1pembrolizumab 1peginterferon alfa-2b 1omburtamab I-131 1mafosfamide 1immunotoxin LMB-7 1gallium citrate 1azeliragon 1avelumab 1adavosertib 1Vitamin B 12 1Vinorelbine 1Trastuzumab 1Temozolomide 1Specimen Handling 1Rituximab 1Pentetic Acid 1Melphalan 1Magnetic Resonance Spectroscopy 1Interferons 1Immunotherapy, Adoptive 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

1 trials
RecentStart dateEnrollment
Phase 1 × Meningeal Carcinomatosis × avelumab × Clear all
NCT03719768 2026-03-02

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

H. Lee Moffitt Cancer Center and Research Institute

Phase 1 Completed
16 enrolled
CNS

Brain Neoplasms, Meningeal Neoplasms, Meningeal Carcinomatosis

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