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Phase

Phase 1 1

Status

Completed 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

CNS 1

Conditions

Neoplasms 11Carcinoma, Non-Small-Cell Lung 11Carcinoma, Transitional Cell 9Carcinoma, Renal Cell 8Colorectal Neoplasms 7Urinary Bladder Neoplasms 6Ovarian Neoplasms 6Neoplasm Metastasis 6Squamous Cell Carcinoma of Head and Neck 4Recurrence 3Glioblastoma 3Carcinoma, Neuroendocrine 3Triple Negative Breast Neoplasms 2Stomach Neoplasms 2Sarcoma 2Neuroendocrine Tumors 2Kidney Neoplasms 2Kidney Diseases 2Head and Neck Neoplasms 2Glioma 2Fallopian Tube Neoplasms 2Carcinoma, Merkel Cell 2Carcinoma, Hepatocellular 2Uterine Cervical Neoplasms 1Urothelial Cancer 1Urologic Neoplasms 1Urethral Neoplasms 1Ureteral Neoplasms 1Testicular Neoplasms 1Testicular Diseases 1

Interventions

Pemetrexed 5Topotecan 3Dexamethasone 3Bevacizumab 3osimertinib 2Vitamin B 12 2Trastuzumab 2Spinal Puncture 2Radiotherapy 2Methotrexate 2Folic Acid 2Cytarabine 2Busulfan 2trioctyl phosphine oxide 1trastuzumab deruxtecan 1tipifarnib 1merphos 1mafosfamide 1immunotoxin LMB-7 1epothilone B 1avelumab 1aflutinib 1XL647 1Transplantation, Autologous 1Temozolomide 1Rituximab 1Referral and Consultation 1Radiotherapy, Intensity-Modulated 1Nivolumab 1Mental Status and Dementia Tests 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Completed × Meningeal Carcinomatosis × avelumab × Clear all
NCT03719768 2026-03-02

Avelumab With Radiotherapy in Patients With Leptomeningeal Disease

H. Lee Moffitt Cancer Center and Research Institute

Phase 1 Completed
16 enrolled
CNS

Brain Neoplasms, Meningeal Neoplasms, Meningeal Carcinomatosis

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