Announcements Trials
Browse Landscape

Phase

Phase 2 3Phase NA 1

Status

Unknown 2Recruiting 1Completed 1

Sponsor Class

OTHER 4INDUSTRY 2

Study Type

Interventional 4

Sponsor

Cancer Type

CNS 4Thoracic 2

Conditions

Carcinoma, Non-Small-Cell Lung 92Lung Neoplasms 32NSCLC 7Brain Neoplasms 7Meningeal Carcinomatosis 4Neoplasm Metastasis 3Carcinoma, Squamous Cell 2Bronchial Neoplasms 2Adenocarcinoma of Lung 2Small Cell Lung Carcinoma 1Sexual Dysfunction, Physiological 1Resectable Non-small Cell Lung Cancer 1Rare Tumour 1Prostatic Neoplasms 1Progression Free Survival 1Pancreatic Neoplasms 1Ovarian Neoplasms 1Non-small Cell Carcinoma 1Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor (Disorder) 1Non-Small Cell Lung Cancer With EGFR T790M Mutation 1Non-Small Cell Lung Cancer With EGFR Mutation 1Non Small Cell Lung Cancer Metastatic 1Neurocognitive 1Neoplastic Cells, Circulating 1Neoplasm, Residual 1Lung Cancer Metastatic 1Locally Advanced or Metastatic EGFRm Non-small Cell Lung Cancer (NSCLC) 1Glioblastoma 1Eunuchism 1Erectile Dysfunction 1

Interventions

Pemetrexed 18Bevacizumab 9Spinal Puncture 7Radiotherapy 7Specimen Handling 5Methotrexate 5Magnetic Resonance Spectroscopy 5osimertinib 4aflutinib 4Trastuzumab 3Topotecan 3Temozolomide 3Dexamethasone 3trastuzumab deruxtecan 2pembrolizumab 2merphos 2lorlatinib 2Vitamin B 12 2Rituximab 2Radiotherapy, Intensity-Modulated 2Folic Acid 2Drug Therapy 2Cytarabine 2Cyclophosphamide 2tucatinib 1toripalimab 1sintilimab 1sacituzumab govitecan 1pertuzumab 1peginterferon alfa-2b 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
OTHER × Meningeal Carcinomatosis × osimertinib × Clear all
NCT06304441 2025-09-29

Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer

Guangzhou Medical University

Phase NA Recruiting
100 enrolled
CNS

Meningeal Carcinomatosis

NCT04233021 2025-02-03

ORBITAL

Intergroupe Francophone de Cancerologie Thoracique

Phase 2 Completed
57 enrolled
CNS

Brain Neoplasms, Meningeal Carcinomatosis

NCT04425681 2020-06-11

OWBLM

Second Affiliated Hospital of Nanchang University

Phase 2 Unknown
20 enrolled
CNSThoracic

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT04148898 2019-11-04

OWONBNSCLCLM

Second Affiliated Hospital of Nanchang University

Phase 2 Unknown
80 enrolled
CNSThoracic

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

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