Announcements Trials
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Phase

Phase 1 15Phase 2 14Phase 1/2 5Phase NA 4Phase EARLY_PHASE1 1Phase 3 1

Status

Recruiting 5Completed 5Active not recruiting 2Withdrawn 1Terminated 1Not yet recruiting 1

Sponsor Class

OTHER 5

Study Type

Interventional 5

Sponsor

Cancer Type

CNS 5Breast 1

Conditions

Breast Neoplasms 264Carcinoma, Non-Small-Cell Lung 219Neoplasms 218Leukemia, Myeloid, Acute 193Multiple Myeloma 178Colorectal Neoplasms 175Melanoma 165Prostatic Neoplasms 163Lymphoma 145Leukemia 142Lymphoma, Non-Hodgkin 133Glioblastoma 131Pancreatic Neoplasms 127Neoplasm Metastasis 118Lung Neoplasms 118Leukemia, Lymphocytic, Chronic, B-Cell 118Ovarian Neoplasms 112Precursor Cell Lymphoblastic Leukemia-Lymphoma 106Recurrence 97Myelodysplastic Syndromes 93Hodgkin Disease 92Lymphoma, Large B-Cell, Diffuse 89Lymphoma, Follicular 89Lymphoma, Mantle-Cell 83Head and Neck Neoplasms 79Carcinoma, Renal Cell 79Brain Neoplasms 77Sarcoma 73Carcinoma, Hepatocellular 73Squamous Cell Carcinoma of Head and Neck 71

Interventions

Pemetrexed 2Dexamethasone 2Vitamin B 12 1Trastuzumab 1Radiotherapy 1Folic Acid 1Bevacizumab 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Phase 1/2 × Completed × Meningeal Carcinomatosis × Clear all
NCT01373710 2025-11-24

HIT

Institut Curie

Phase 1/2 Completed
34 enrolled
BreastCNS

Breast Neoplasms, Meningeal Carcinomatosis

NCT05289908 2025-05-04

Intrathecal Pemetrexed for Leptomeningeal Metastasis

The First Hospital of Jilin University

Phase 1/2 Completed
34 enrolled
CNS

Meningeal Carcinomatosis

NCT00924820 2020-12-31

A Pilot Study of Bevacizumab for Neoplastic Meningitis

M.D. Anderson Cancer Center

Phase 1/2 Completed
20 enrolled 7 charts
CNS

Brain Diseases, Brain Neoplasms, Central Nervous System Diseases, Meningeal Carcinomatosis

NCT03507244 2019-12-26

Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors

The First Hospital of Jilin University

Phase 1/2 Completed
34 enrolled
CNS

Meningeal Carcinomatosis

NCT00002751 2013-06-20

Monoclonal Antibody Therapy in Treating Patients With Brain Metastases

Duke University

Phase 1/2 Completed
6 enrolled
CNS

Neoplasm Metastasis, Meningeal Carcinomatosis

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