Clinical Trials
25 trialsNCT06724926 2026-05-18
Concurrent Azeliragon With Craniospinal Irradiation
NYU Langone Health
Phase 1 Active not recruiting
NCT06431685 2026-05-08
Safety and Efficacy of Whole Brain LDRT+ICI+Intrathecal Chemotherapy in Refractory Meningeal Metastasis of Lung Cancer
Sichuan University
Phase 1 Recruiting
NCT03696030 2026-04-23
HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases
City of Hope Medical Center
Phase 1 Active not recruiting
NCT04192981 2026-04-22
GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases
Memorial Sloan Kettering Cancer Center
Phase 1 Active not recruiting
NCT05184816 2026-03-27
A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis
Memorial Sloan Kettering Cancer Center
Phase 1 Recruiting
NCT04661384 2026-03-05
Brain Tumor-Specific Immune Cells (IL13Ralpha2-CAR T Cells) for the Treatment of Leptomeningeal Glioblastoma, Ependymoma, or Medulloblastoma
City of Hope Medical Center
Phase 1 Active not recruiting
NCT03719768 2026-03-02
Avelumab With Radiotherapy in Patients With Leptomeningeal Disease
H. Lee Moffitt Cancer Center and Research Institute
Phase 1 Completed
NCT06663306 2026-03-02
Intrathecal Injection Pemetrexed And Bevacizumab in Patients With Leptomeningeal Metastases in NSCLC
Shanghai Chest Hospital
Phase 1 Recruiting
NCT05598853 2025-10-02
IT-IO
University of Zurich
Phase 1 Active not recruiting
NCT07199413 2025-09-30
Allogeneic, Antigen-Presenting, GM-CSF-secreting, SV-BR-1-GM Whole Cell-Therapeutic Vaccine and Immunotherapy: A Phase I Pilot Safety and Feasibility Study for Solid Tumor Patients With CNS Metastases
Medical College of Wisconsin
Phase 1 Not yet recruiting
NCT06137651 2024-04-01
Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis
Northwestern University
Phase 1 Withdrawn
NCT03520504 2022-12-23
Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases
Memorial Sloan Kettering Cancer Center
Phase 1 Completed
NCT03661424 2022-12-20
BATs in Patients With Breast Cancer and Leptomeningeal Metastases
University of Virginia
Phase 1 Terminated
NCT02423525 2022-03-10
Safety Study of Afatinib for Brain Cancer
Saint John's Cancer Institute
Phase 1 Completed
NCT03101579 2019-03-19
Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer
The First Hospital of Jilin University
Phase 1 Completed
NCT00512460 2016-05-16
RTA 744 Injection in Patients With Leptomeningeal Disease
M.D. Anderson Cancer Center
Phase 1 Terminated
NCT00416923 2015-02-16
Intrathecal Rituximab in Treating Patients With Recurrent CNS Lymphoma
University of California, San Francisco
Phase 1 Completed
NCT00002750 2013-02-20
Melphalan in Patients With Neoplastic Meningitis
Duke University
Phase 1 Completed
NCT00003020 2013-02-20
LMB-7 Immunotoxin in Treating Patients With Leptomeningeal Metastases
Duke University
Phase 1 Completed
NCT00003462 2013-02-20
Intrathecal Busulfan in Treating Patients With Recurrent, Refractory, or Metastatic Leptomeningeal Tumors
Duke University
Phase 1 Completed
NCT00074607 2012-11-12
Intrathecal Gemcitabine to Treat Neoplastic Meningitis, IT Gemcitabine
Baylor College of Medicine
Phase 1 Terminated
NCT00025311 2012-11-09
Topotecan in Treating Patients With Recurrent, Progressive, or Refractory Cancer That is Metastatic to the Lining Around the Brain
NYU Langone Health
Phase 1 Completed
NCT00477503 2012-08-01
Nuclear Imaging of Human CSF Flow Using Ga-67 Citrate and In-111 DTPA
M.D. Anderson Cancer Center
Phase 1 Terminated
NCT00674674 2012-05-15
PBTC-019
Baylor College of Medicine
Phase 1 Completed
NCT00515788 2012-03-12
DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis
M.D. Anderson Cancer Center
Phase 1 Terminated