Announcements Trials
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Phase

Phase 1 8Phase 2 5Phase NA 1Phase 2/3 1Phase 1/2 1

Status

Completed 14Recruiting 10Unknown 7Terminated 5Not yet recruiting 4

Sponsor Class

OTHER 5

Study Type

Interventional 5

Sponsor

Cancer Type

CNS 5Thoracic 1Other hematologic neoplasm 1Lymphoid 1

Conditions

Breast Neoplasms 413Carcinoma, Non-Small-Cell Lung 286Prostatic Neoplasms 208Neoplasms 204Neoplasm Metastasis 180Melanoma 164Multiple Myeloma 158Colorectal Neoplasms 158Leukemia, Myeloid, Acute 143Lung Neoplasms 132Leukemia 126Lymphoma 118Pancreatic Neoplasms 117Recurrence 111Ovarian Neoplasms 111Leukemia, Lymphocytic, Chronic, B-Cell 110Lymphoma, Non-Hodgkin 105Carcinoma, Renal Cell 104Brain Neoplasms 90Myelodysplastic Syndromes 88Precursor Cell Lymphoblastic Leukemia-Lymphoma 86Glioblastoma 85Lymphoma, Large B-Cell, Diffuse 80Lymphoma, Follicular 79Carcinoma, Hepatocellular 79Head and Neck Neoplasms 77Squamous Cell Carcinoma of Head and Neck 76Urinary Bladder Neoplasms 66Stomach Neoplasms 61Hodgkin Disease 60

Interventions

pembrolizumab 1lenvatinib 1Topotecan 1Temozolomide 1Erlotinib Hydrochloride 1Cyclophosphamide 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Phase 2 × Terminated × Meningeal Carcinomatosis × Clear all
NCT04729348 2025-07-25

Pembrolizumab And Lenvatinib In Leptomeningeal Metastases

Massachusetts General Hospital

Phase 2 Terminated
10 enrolled
CNS

Meningeal Carcinomatosis

NCT02684071 2020-01-10

Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors

Nicklaus Children's Hospital f/k/a Miami Children's Hospital

Phase 2 Terminated
3 enrolled
CNS

Familial ependymoma, Ependymoma, Medulloblastoma, Neuroectodermal Tumors, Primitive, Rhabdoid Tumor, Meningeal Carcinomatosis

NCT00523939 2013-06-17

DepoCyt for Active Lymphomatous or Leukemic Meningitis

Duke University

Phase 2 Terminated
4 enrolled 6 charts
CNSLymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Lymphoma, B-Cell, Meningeal Carcinomatosis

NCT00005812 2013-05-14

Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma

Dartmouth-Hitchcock Medical Center

Phase 2 Terminated
12 enrolled
CNS

Brain Neoplasms, Central Nervous System Neoplasms, Meningeal Carcinomatosis

NCT00830245 2011-07-26

A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR Mutation Positive Non-small Cell Lung Cancer

Clinical Research Center for Solid Tumor, Korea

Phase 2 Terminated
20 enrolled
CNSThoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

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