Clinical Trials Browser

Phase NA × Interventional × Meningeal Carcinomatosis × Clear all

NCT07398599 2026-04-23

Double-Dose Third-Generation EGFR-TKI Plus Bevacizumab and Intrathecal Chemotherapy for Refractory Leptomeningeal Metastatic NSCLC: A Phase II Study

Phase NA Recruiting

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Meningeal Carcinomatosis

NCT05746325 2026-04-02

Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients With Breast or Lung Cancer

Phase NA Recruiting

BreastCNSThoracic

Breast Neoplasms, Lung Neoplasms, Meningeal Carcinomatosis

NCT07348965 2026-04-02

Pulsatile High-dose Furmonertinib in EGFR-mutant NSCLC With Leptomeningeal Metastasis

Phase NA Recruiting

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT06984523 2026-03-31

Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal Metastasis

Phase NA Active not recruiting

Meningeal Carcinomatosis

NCT05286684 2026-03-18

Exo-LCR

Phase NA Completed

Breast Neoplasms, Meningeal Carcinomatosis

NCT06592092 2026-01-29

Clinical Study of QH104 Cell Injection for the Treatment of Meningeal Metastases of B7H3+ Solid Tumors

Phase NA Completed

Meningeal Carcinomatosis

NCT06304441 2025-09-29

Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer

Phase NA Recruiting

Meningeal Carcinomatosis

NCT03974204 2025-09-26

Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis.

Phase NA Withdrawn

Breast Neoplasms, Meningeal Carcinomatosis

NCT05746754 2025-04-06

CSI ProLong

Phase NA Recruiting

Meningeal Carcinomatosis

NCT06643000 2025-03-06

Evaluating High-dose Furmonertinib with Bevacizumab and Pemetrexed for EGFRm NSCLC with Leptomeningeal Metastasis

Phase NA Recruiting

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT05257967 2025-02-11

CSF Analysis in EGFR Mutant Non-Small Cell Lung Cancer With Leptomeningeal Disease

Phase NA Recruiting

Carcinoma, Non-Small-Cell Lung, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT06766591 2025-01-09

Ivonescimab Combined With Chemotherapy for the Treatment of Leptomeningeal Metastases Failed to EGFR-TKIs

Phase NA Not yet recruiting

Meningeal Carcinomatosis

NCT05305885 2022-09-30

Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis

Phase NA Unknown

Meningeal Carcinomatosis

NCT04778800 2021-08-31

A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY)

Phase NA Unknown

Brain Neoplasms, Meningeal Carcinomatosis

NCT04944069 2021-06-29

ATTRACT

Phase NA Unknown

Carcinoma, Non-Small-Cell Lung, Meningeal Carcinomatosis

NCT01713699 2021-01-22

Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases

Phase NA Completed

Neoplastic Cells, Circulating, Meningeal Carcinomatosis

NCT04178343 2019-11-26

Tomotherapy for Leptomeningeal Metastases

Phase NA Completed

Meningeal Carcinomatosis

NCT03027544 2017-01-23

TRBM

Phase NA Unknown

Brain Neoplasms, Meningeal Carcinomatosis

NCT00964743 2013-09-09

Depocyt® With Sorafenib in Neoplastic Meningitis

Phase NA Terminated

2 enrolled 6 charts

Breast Neoplasms, Neurologic Manifestations, Meningeal Carcinomatosis

NCT01438021 2012-11-09

Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease

Phase NA Withdrawn

Meningeal Carcinomatosis

NCT00938756 2010-04-07

Study of Cerebrospinal Fluid Samples in Diagnosing Carcinomatous Meningitis in Patients With Cancer or Meningeal Syndrome

Phase NA Unknown

Brain Neoplasms, Breast Neoplasms, Meningioma, Neoplasm Metastasis, Central Nervous System Neoplasms, Breast Neoplasms, Male, Meningeal Carcinomatosis