Announcements Trials
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Phase

Phase 2 3Phase 3 1

Status

Recruiting 2Unknown 1Terminated 1

Sponsor Class

OTHER 3INDUSTRY 1

Study Type

Interventional 4

Sponsor

Cancer Type

Breast 3CNS 2

Conditions

Breast Neoplasms 387Colorectal Neoplasms 307Rectal Neoplasms 225Stomach Neoplasms 206Pancreatic Neoplasms 137Neoplasm Metastasis 121Colonic Neoplasms 93Neoplasms 85Triple Negative Breast Neoplasms 63Esophageal Neoplasms 57Biliary Tract Neoplasms 37Nasopharyngeal Carcinoma 36Adenocarcinoma 31Cholangiocarcinoma 30Carcinoma, Hepatocellular 30Gallbladder Neoplasms 28Carcinoma, Non-Small-Cell Lung 21Bile Duct Neoplasms 21Locally Advanced Rectal Cancer 20Adenocarcinoma Of Esophagus 20Squamous Cell Carcinoma of Head and Neck 19Gastrointestinal Neoplasms 18Brain Neoplasms 18Parkinson Disease 4, Autosomal Dominant Lewy Body 17Liver Neoplasms 17Head and Neck Neoplasms 17Esophageal Squamous Cell Carcinoma 17Ovarian Neoplasms 14Colorectal Cancer Metastatic 14Breast Neoplasms, Male 14

Interventions

Trastuzumab 4Capecitabine 4tucatinib 3fludarabine 2Spinal Puncture 2Radiotherapy 2Nivolumab 2Methotrexate 2Magnetic Resonance Spectroscopy 2Cyclophosphamide 2sapanisertib 1pertuzumab 1patritumab deruxtecan 1paclitaxel-Angiopep-2 conjugate 1mafosfamide 1gadopiclenol 1gadobutrol 1fludarabine phosphate 1eribulin 1avelumab 1aldesleukin 1WP 744 1Topotecan 1Temozolomide 1Specimen Handling 1Rituximab 1Phlebotomy 1Mesna 1Interleukin-2 1Cytarabine 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Interventional × Meningeal Neoplasms × Capecitabine × Clear all
NCT06016387 2026-02-23

Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study

Sunnybrook Health Sciences Centre

Phase 2 Recruiting
30 enrolled
Breast

Breast Neoplasms, Meningeal Neoplasms

NCT05800275 2025-11-18

ETIC-LM

UNICANCER

Phase 2 Recruiting
30 enrolled
CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

NCT03501979 2025-08-29

Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD

University of Alabama at Birmingham

Phase 2 Terminated
17 enrolled 16 charts
Breast

Breast Neoplasms, Meningeal Neoplasms

NCT03613181 2023-04-24

ANGLeD

Angiochem Inc

Phase 3 Unknown
150 enrolled
BreastCNS

Brain Neoplasms, Breast Neoplasms, Meningeal Neoplasms, Meningeal Carcinomatosis

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