Announcements Trials
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Phase

Phase 2 2

Status

Recruiting 2Terminated 1Active not recruiting 1

Sponsor Class

OTHER 2

Study Type

Interventional 2

Sponsor

Cancer Type

CNS 1Breast 1

Conditions

Breast Neoplasms 49Stomach Neoplasms 11Neoplasms 10HER2-positive Breast Cancer 8Colorectal Neoplasms 8Neoplasm Metastasis 7Esophageal Neoplasms 5Triple Negative Breast Neoplasms 4Salivary Gland Neoplasms 3Ovarian Neoplasms 3Lung Neoplasms 3Endometrial Neoplasms 3Carcinoma, Non-Small-Cell Lung 3Adenocarcinoma 3Squamous Cell Carcinoma of Head and Neck 2Pathologic Complete Response 2Pancreatic Neoplasms 2Multiple Myeloma 2Meningeal Neoplasms 2Lymphoma, Non-Hodgkin 2Hematologic Neoplasms 2HER2-positive Early Breast Cancer 2Colonic Neoplasms 2Biliary Tract Neoplasms 2Anatomic Stage I Breast Cancer AJCC v8 2Adenocarcinoma Of Esophagus 2Urinary Bladder Neoplasms 1Skin Neoplasms 1Resectable HER2-positive Breast Cancer 1Rectal Neoplasms 1

Interventions

tucatinib 2Trastuzumab 2Spinal Puncture 2Nivolumab 2Capecitabine 2Specimen Handling 1Radiotherapy 1Phlebotomy 1Methotrexate 1Magnetic Resonance Spectroscopy 1Blood Specimen Collection 1AZD1390 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Recruiting × Meningeal Neoplasms × Trastuzumab × Clear all
NCT06016387 2026-02-23

Tucatinib, Trastuzumab and Capecitabine With Brain and/or Spinal Radiotherapy (XRT) in Patients With HER2+, HER2 Mutated and/or HER2-amplified Metastatic Breast Cancer and Leptomeningeal Disease: A Multi-centre Phase II, Single Arm Feasibility Study

Sunnybrook Health Sciences Centre

Phase 2 Recruiting
30 enrolled
Breast

Breast Neoplasms, Meningeal Neoplasms

NCT05800275 2025-11-18

ETIC-LM

UNICANCER

Phase 2 Recruiting
30 enrolled
CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

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