Announcements Trials
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Phase

Phase 1 3Phase 2 1Phase 1/2 1

Status

Recruiting 10Completed 6Terminated 5Active not recruiting 5Not yet recruiting 2Unknown 1

Sponsor Class

OTHER 5

Study Type

Interventional 5Observational 1

Sponsor

Cancer Type

CNS 3Other hematologic neoplasm 2Thoracic 1Lymphoid 1Breast 1

Conditions

Breast Neoplasms 993Neoplasms 852Carcinoma, Non-Small-Cell Lung 845Prostatic Neoplasms 528Neoplasm Metastasis 501Leukemia, Myeloid, Acute 489Melanoma 456Colorectal Neoplasms 447Multiple Myeloma 441Lung Neoplasms 422Pancreatic Neoplasms 353Recurrence 350Lymphoma 350Ovarian Neoplasms 341Lymphoma, Non-Hodgkin 329Leukemia 324Leukemia, Lymphocytic, Chronic, B-Cell 302Precursor Cell Lymphoblastic Leukemia-Lymphoma 271Carcinoma, Renal Cell 256Head and Neck Neoplasms 246Brain Neoplasms 245Carcinoma, Hepatocellular 234Glioblastoma 232Squamous Cell Carcinoma of Head and Neck 231Myelodysplastic Syndromes 231Lymphoma, Large B-Cell, Diffuse 228Lymphoma, Follicular 219Colonic Neoplasms 191Stomach Neoplasms 182Rectal Neoplasms 175

Interventions

tucatinib 1WP 744 1Trastuzumab 1Temozolomide 1Rituximab 1Capecitabine 1Afatinib 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Terminated × Interventional × Meningeal Neoplasms × Clear all
NCT03501979 2025-08-29

Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD

University of Alabama at Birmingham

Phase 2 Terminated
17 enrolled 16 charts
Breast

Breast Neoplasms, Meningeal Neoplasms

NCT03711422 2022-06-14

Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC

National Cancer Centre, Singapore

Phase 1 Terminated
2 enrolled
Thoracic

Carcinoma, Non-Small-Cell Lung, Meningeal Neoplasms

NCT01596127 2018-05-24

Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System

M.D. Anderson Cancer Center

Phase 1/2 Terminated
4 enrolled 7 charts
CNSOther hematologic neoplasm

Central Nervous System Diseases, Leukemia, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00512460 2016-05-16

RTA 744 Injection in Patients With Leptomeningeal Disease

M.D. Anderson Cancer Center

Phase 1 Terminated
7 enrolled
CNSLymphoidOther hematologic neoplasm

Brain Neoplasms, Leukemia, Lymphoma, Meningeal Neoplasms, Meningeal Carcinomatosis

NCT00515788 2012-03-12

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

M.D. Anderson Cancer Center

Phase 1 Terminated
11 enrolled
CNS

Meningeal Neoplasms, Meningeal Carcinomatosis

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