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Phase

Phase 1 2Phase 1/2 1

Status

Terminated 1

Sponsor Class

NIH 1

Study Type

Interventional 1

Sponsor

Cancer Type

Thoracic 1Other solid neoplasm 1Gastrointestinal 1

Conditions

Leukemia, Myeloid, Acute 28Myelodysplastic Syndromes 13Leukemia 8Recurrence 6Melanoma 5Leukemia, Myelomonocytic, Chronic 5Precursor Cell Lymphoblastic Leukemia-Lymphoma 4Ovarian Neoplasms 3Neoplasms 3Carcinoma, Non-Small-Cell Lung 3Blast Crisis 3Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 2Precursor B-Cell Lymphoblastic Leukemia-Lymphoma 2Neoplasm Metastasis 2Myelodysplastic-Myeloproliferative Diseases 2Lymphoma, Non-Hodgkin 2Leukemia, Myeloid, Accelerated Phase 2Leukemia, Biphenotypic, Acute 2Thrombocytopenia 1Skin Neoplasms 1Sarcoma, Synovial 1Refractory or Relapsed Aggressive r/r B-NHL With Huge Tumor Burden 1Prostatic Neoplasms 1Peripheral Blood Stem Cell Transplantation 1Neuroectodermal Tumors, Primitive 1Myeloproliferative Disorders 1Myeloid Malignancies 1Mesothelioma, Malignant 1Medulloblastoma 1Lymphoma, Large B-Cell, Diffuse 1

Interventions

Pemetrexed 7Cisplatin 7Cyclophosphamide 5pembrolizumab 4fludarabine 4Platinum 3Drug Therapy 3aldesleukin 2Nivolumab 2Ipilimumab 2Interleukin-2 21,2-diaminocyclohexaneplatinum II citrate 2vatalanib 1spartalizumab 1regorafenib 1napabucasin 1methoxyamine 1fludarabine phosphate 1enzalutamide 1cediranib 1avelumab 1atezolizumab 1anetumab ravtansine 1Vorinostat 1Thiostrepton 1Tetrahydrouridine 1Radiosurgery 1Megestrol Acetate 1Levoleucovorin 1Leucovorin 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

1 trials
RecentStart dateEnrollment
Phase 1/2 × Mesothelioma, Malignant × Decitabine × Clear all
NCT03233724 2023-05-31

Oral Decitabine and Tetrahydrouridine as Epigenetic Priming for Pembrolizumab-Mediated Immune Checkpoint Blockade in Patients With Inoperable, or Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancers and Esophageal Carcinomas

National Institutes of Health Clinical Center (CC)

Phase 1/2 Terminated
9 enrolled 14 charts
GastrointestinalOther solid neoplasmThoracic

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Lung Neoplasms

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