Clinical Trials

9 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Pleural Diseases

NCT03420963 2026-03-20

Donor Natural Killer Cells, Cyclophosphamide, and Etoposide in Treating Children and Young Adults With Relapsed or Refractory Solid Tumors

DermatologicGenitourinaryHead & NeckOther solid neoplasmSarcomaThoracic

12 enrolled

Mesothelioma, Malignant, Bone Neoplasms, Endocrine Gland Neoplasms, Melanoma, Mouth Neoplasms, Pharyngeal Neoplasms, Sarcoma, Skin Neoplasms, Thyroid Neoplasms, Urologic Neoplasms

NCT04897022 2026-03-12

A Study of Pembrolizumab and Radiation Therapy in People With Mesothelioma

7 enrolled

Mesothelioma, Malignant

NCT06566079 2026-02-17

Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors

100 enrolled

Mesothelioma, Malignant, Neoplasm Metastasis

NCT07192900 2026-01-15

(RIOT 4A)

10 enrolled

Mesothelioma, Malignant, Pleural Effusion, Malignant

NCT03760575 2025-12-04

Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM)

20 enrolled

Mesothelioma, Malignant

NCT04162015 2025-09-12

A Study of Nivolumab and Chemotherapy Followed by Surgery for Mesothelioma

22 enrolled

Mesothelioma, Malignant

NCT05107674 2025-09-09

A Study of NX-1607 in Adults With Advanced Malignancies

BreastGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther solid neoplasmThoracic

345 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Lymphoma, Large B-Cell, Diffuse, Triple Negative Breast Neoplasms

NCT04577326 2025-07-25

Mesothelin-targeted CAR T-cell Therapy in Patients With Mesothelioma

14 enrolled

Mesothelioma, Malignant

NCT06299163 2025-07-23

NM32-2668 in Adult Patients With Selected Advanced Solid Tumors

BreastDermatologicGenitourinaryGynecologicOther solid neoplasmSarcomaThoracic

11 enrolled

Adenocarcinoma of Lung, Mesothelioma, Malignant, Carcinoma, Renal Cell, Fallopian Tube Neoplasms, Leiomyosarcoma, Liposarcoma, Melanoma, Ovarian Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT04525859 2025-06-24

Poly-ICLC (Hiltonol®) Vaccine In Malignant Pleural Mesothelioma

19 enrolled

Mesothelioma, Malignant

NCT03917043 2025-06-18

APG-2449 in Patients With Advanced Solid Tumors

GastrointestinalGynecologicOther solid neoplasmThoracic

165 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Ovarian Neoplasms

NCT04040231 2025-05-13

Using a Targeted Cancer Vaccine (Galinpepimut-S) With Immunotherapy (Nivolumab) in Mesothelioma

GenitourinaryOther solid neoplasmThoracic

10 enrolled

Mesothelioma, Malignant, Mesothelioma, Wilms Tumor

NCT03054298 2025-04-29

CAR T Cells in Mesothelin Expressing Cancers

GynecologicOther solid neoplasmThoracic

65 enrolled 14 charts

Adenocarcinoma of Lung, Mesothelioma, Malignant, Fallopian Tube Neoplasms, Ovarian Neoplasms

NCT05304208 2025-04-25

ENSURE

16 enrolled

Mesothelioma, Malignant

NCT03212404 2025-02-03

Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers

DermatologicGenitourinaryGynecologicHead & NeckLymphoidOther solid neoplasmThoracic

272 enrolled 1 FDA

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Head and Neck Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Melanoma, Neoplasms, Skin Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Carcinoma, Small Cell

NCT06469138 2025-01-29

8479217

CNSDermatologicGastrointestinalMyeloidOther hematologic neoplasmOther solid neoplasmThoracic

6 enrolled 17 charts

Mesothelioma, Malignant, COVID-19, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Melanoma, Myelodysplastic Syndromes, Pancreatic Neoplasms, Leukemia, Myeloid, Acute

NCT06726564 2024-12-10

A Study of MT027 in Patients with Pleural Malignant Tumors

18 enrolled

Mesothelioma, Malignant, Neoplasm Metastasis, Pleural Effusion, Malignant

NCT05228015 2024-11-18

Oral TEAD Inhibitor Targeting the Hippo Pathway in Subjects with Advanced Solid Tumors

67 enrolled

Mesothelioma, Malignant, Hemangioendothelioma, Epithelioid

NCT03546426 2024-10-01

MESOVAX

18 enrolled

Mesothelioma, Malignant, Disease Progression

NCT02707666 2024-07-31

A Pilot Window-Of-Opportunity Study of the Anti-PD-1 Antibody Pembrolizumab in Patients With Resectable Malignant Pleural Mesothelioma

7 enrolled

Mesothelioma, Malignant

NCT06256055 2024-07-24

Phase 1 Study of UCMYM802 Injection in Mesothelin-positive Advanced Malignant Solid Tumors

GastrointestinalGynecologicOther solid neoplasmThoracic

24 enrolled

Mesothelioma, Malignant, Bile Duct Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT05538572 2024-07-01

A Study of PRT3645 in Participants With Select Advanced or Metastatic Solid Tumors

BreastCNSGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

22 enrolled

Squamous Cell Carcinoma of Head and Neck, Mesothelioma, Malignant, Breast Neoplasms, Glioblastoma, Sarcoma, Endometrial Neoplasms

NCT06281860 2024-02-28

PITHAC

BreastGastrointestinalGynecologicOther solid neoplasmThoracic

39 enrolled

Mesothelioma, Malignant, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Ovarian Neoplasms, Stomach Neoplasms

NCT05375825 2024-02-02

Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin

Phase 1 Withdrawn

MyeloidOther solid neoplasmThoracic

Myeloproliferative Disorder, Chronic, with Eosinophilia, Mesothelioma, Malignant, Carcinoma, Pleural Effusion, Malignant

NCT05498597 2023-10-19

AMT-151 in Patients With Selected Advanced Solid Tumours

BreastGynecologicOther solid neoplasmThoracic

30 enrolled

Adenocarcinoma of Lung, Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Carcinoma, Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT04042480 2023-03-23

A Study of SGN-CD228A in Advanced Solid Tumors

DermatologicGastrointestinalOther solid neoplasmThoracic

88 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Melanoma, Colorectal Neoplasms

NCT03507452 2023-03-20

First-in-human Study of BAY2287411 Injection, a Thorium-227 Labeled Antibody-chelator Conjugate, in Patients With Tumors Known to Express Mesothelin

36 enrolled

Phase 1 Not yet recruiting

Mesothelioma, Malignant

NCT05698238 2023-03-15

CAMP1

50 enrolled

BreastGenitourinaryHead & NeckOther solid neoplasmThoracic

Clear-cell metastatic renal cell carcinoma, Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Triple Negative Breast Neoplasms

NCT04430842 2023-01-18

Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

15 enrolled

Sleepiness, Mesothelioma, Malignant, Anorexia, Astrocytoma, Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Uterine Cervical Neoplasms, Esophageal Neoplasms, Glioblastoma, Head and Neck Neoplasms, Headache, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Seizures, Speech Disorders, Stomach Neoplasms, Thymoma, Tongue Neoplasms, Urologic Neoplasms, Vomiting, Colorectal Neoplasms, Cholangiocarcinoma

NCT02555007 2022-11-17

NVB Metro

30 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung

NCT00652574 2022-10-31

Dasatinib in Resectable Malignant Pleural Mesothelioma

56 enrolled

Mesothelioma, Malignant

NCT04173338 2022-06-14

Cabozantinib With Pemetrexed in Advanced Non-small Cell Lung Cancer, Urothelial Cancer and Malignant Mesothelioma

GenitourinaryOther solid neoplasmThoracic

9 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell

NCT01655225 2022-04-08

A Study of LY3023414 in Participants With Advanced Cancer

BreastLymphoidOther solid neoplasmThoracic

156 enrolled

Mesothelioma, Malignant, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Lymphoma, Lymphoma, Non-Hodgkin, Mesothelioma, Neoplasm Metastasis

NCT03852823 2021-04-30

Study of Recombinant Human Anti-PD-1 Monoclonal Antibody in Patients With Advanced Tumours

GynecologicLymphoidOther solid neoplasmThoracic

192 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Lymphoma

NCT01503177 2021-01-11

Intrapleural Measles Virus Therapy in Patients With Malignant Pleural Mesothelioma

15 enrolled

Mesothelioma, Malignant

NCT00535951 2020-12-19

Pharmacokinetic, Safety, and Efficacy Effects of Oral LBH589 on Dextromethorphan in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer or Malignant Pleural Mesothelioma

18 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Mesothelioma

NCT04201145 2020-11-17

Pembrolizumab + Defactinib In Pleural Mesothelioma

Phase 1 Withdrawn

Mesothelioma, Malignant

NCT01675765 2020-09-30

Safety and Efficacy of Listeria in Combination With Chemotherapy as Front-line Treatment for Malignant Pleural Mesothelioma

60 enrolled 15 charts

Mesothelioma, Malignant, Neoplasms

NCT00066404 2020-05-13

Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions

BreastDermatologicGastrointestinalGenitourinaryGynecologicOther solid neoplasmThoracic

Carcinoma, Ovarian Epithelial, Mesothelioma, Malignant, Anus Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasms, Pancreatic Neoplasms, Penile Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thymoma, Urethral Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Pleural Effusion, Malignant, Endometrial Neoplasms, Breast Neoplasms, Male, Gestational Trophoblastic Disease, Small Cell Lung Carcinoma

NCT03920839 2020-04-24

INCMGA00012 Plus Chemotherapy in Participants With Advanced Solid Tumors (POD1UM-105)

Phase 1 Withdrawn

Parkinson Disease 4, Autosomal Dominant Lewy Body, Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung

NCT00299962 2020-03-18

Gene Therapy for Pleural Malignancies

17 enrolled