Clinical Trials

Erythroplasia, Hyperplasia, Leukoplakia, Oral, Mouth Neoplasms

NCT02589938 2026-02-27

ACUPUNCTURE

258 enrolled 16 charts

Phase 2 Active not recruiting

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Radiation Injuries, Salivary Gland Neoplasms, Xerostomia

NCT03174275 2026-02-23

Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

39 enrolled 8 charts

GastrointestinalHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Esophageal Neoplasms, Laryngeal Neoplasms, Lip Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT04372914 2026-02-20

Prevention of Oral DNA Damage by Black Raspberries

69 enrolled 14 charts

Mouth Neoplasms, Smoking

NCT03993353 2026-02-12

Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer

GastrointestinalHead & Neck

7 enrolled 14 charts

Pyridoxine-dependent epilepsy, Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Esophageal Neoplasms, Head and Neck Neoplasms, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms

NCT06129487 2025-11-14

Evaluations of Alcohol Warning Labels

GastrointestinalHead & Neck

1,053 enrolled 15 charts

Alcohol Drinking, Esophageal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms

NCT02882282 2025-10-23

Pembrolizumab in Treating Patients With High Risk Oral Intraepithelial Neoplasia

15 enrolled 8 charts

Mouth Neoplasms

NCT02586207 2025-10-07

Pembrolizumab in Combination With CRT for LA-SCCHN

Phase 1 Completed

59 enrolled 9 charts

Phase 2 Active not recruiting

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Diseases, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03529422 2025-07-20

Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN

18 enrolled 10 charts

Lymphoid Interstitial Pneumonia, Laryngeal Diseases, Mouth Neoplasms

NCT04162873 2025-02-12

Celecoxib Through Surgery and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer

13 enrolled 36 charts

Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Paranasal Sinus Neoplasms

NCT03515538 2024-11-04

PREVLAR

53 enrolled 15 charts

Head & NeckOther

Head and Neck Neoplasms, Mouth Neoplasms, Stomatitis, Mucositis

NCT04905134 2024-09-19

Low-Cost, Portable Flexible Nasopharyngoscope in Head & Neck Cancers in Low Resource Settings - Optimization Phase

53 enrolled 6 charts

Head and Neck Neoplasms, Mouth Neoplasms

NCT03422536 2024-09-04

Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma

78 enrolled 16 charts

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Lip Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT04541355 2024-06-28

Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin

16 enrolled 12 charts

Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03254927 2023-04-03

A Study of CDX-3379 and Cetuximab and in Patients With Advanced Head and Neck Squamous Cell Carcinoma

30 enrolled 17 charts

Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT02917629 2023-03-08

ACTOplus Met XR in Treating Patients With Stage I-IV Oral Cavity or Oropharynx Cancer Undergoing Definitive Treatment

6 enrolled 22 charts

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03067610 2022-03-17

INFIELD

72 enrolled 14 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Pharyngeal Neoplasms

NCT04166214 2021-12-03

Oral Pathology Asynchronous Telementoring Pilot Study

51 enrolled 10 charts

Mouth Neoplasms

NCT03875118 2021-04-27

Effects of Mouth-opening Training on the Maximum Interincisal Opening

68 enrolled 6 charts

Mouth Neoplasms, Trismus

NCT03638622 2021-02-21

UH3-India

30 enrolled 4 charts

Mouth Neoplasms

NCT00210470 2020-12-11

A Phase 2 Clinical Trial of the Safety and Effects of IRX-2 in Treating Patients With Operable Head and Neck Cancer

27 enrolled 16 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Mouth Neoplasms

NCT02608879 2020-08-28

OMDP

19 enrolled 17 charts

Mouth Neoplasms, Stomatitis

NCT00833261 2020-08-21

Nab-Paclitaxel, Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer

37 enrolled 6 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Tongue Neoplasms, Carcinoma, Verrucous

NCT00402779 2020-04-21

Erlotinib Prevention of Oral Cancer (EPOC)

Phase 3 Completed

303 enrolled 11 charts

Carcinoma in Situ, Mouth Neoplasms

NCT00524017 2020-03-12

Cetuximab in Treating Patients With Precancerous Lesions of the Upper Aerodigestive Tract

Head & NeckOther neoplasm

35 enrolled 6 charts

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Precancerous Conditions, Salivary Gland Neoplasms

NCT00656513 2019-11-19

Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer

Phase 2/3 Completed

196 enrolled 13 charts

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms, Xerostomia

NCT01806675 2019-10-03

18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy

BreastCNSGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

25 enrolled 14 charts

Brain Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Colonic Neoplasms, Glioblastoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Tongue Neoplasms, Esthesioneuroblastoma, Olfactory, Gliosarcoma, Breast Neoplasms, Male

NCT01194466 2019-09-17

Transcutaneous Electrical Nerve Stimulation (TENS) and Head and Neck Cancer Pain (HNC) (TENS & HNC)

41 enrolled 6 charts

Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Pain, Stomatitis

NCT00721799 2019-08-06

F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients

33 enrolled 39 charts

Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT00790569 2018-06-06

Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking

GastrointestinalGenitourinaryGynecologicHead & NeckOther hematologic neoplasmThoracic

315 enrolled 19 charts

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Tobacco Use Disorder, Leukemia, Myeloid, Acute, Small Cell Lung Carcinoma

NCT01195922 2017-12-06

Rapamycin Therapy in Head and Neck Squamous Cell Carcinoma

37 enrolled 6 charts

GastrointestinalGenitourinaryGynecologicHead & NeckOther hematologic neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Tongue Neoplasms

NCT00666978 2017-11-13

Health Education Counseling With or Without Bupropion in Helping African Americans Stop Smoking

Phase 4 Completed

540 enrolled 25 charts

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Tobacco Use Disorder, Leukemia, Myeloid, Acute, Small Cell Lung Carcinoma

NCT00400205 2017-11-06

Study of Induction Docetaxel, Cisplatin and 5-Fluorouracil

14 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Mouth Neoplasms

NCT00534001 2017-05-30

Bupropion in Helping Adults Stop Smoking

GastrointestinalGenitourinaryGynecologicHead & NeckOther hematologic neoplasmThoracic

95 enrolled 8 charts

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Tobacco Use Disorder, Leukemia, Myeloid, Acute, Small Cell Lung Carcinoma

NCT00953849 2017-03-07

Vitamin D Plus Celecoxib Therapy to Stimulate Intratumoral Immune Reactivity

21 enrolled 10 charts

Mouth Neoplasms

NCT00957424 2017-02-07

Acceptability of Less Harmful Alternatives to Cigarettes

GastrointestinalGenitourinaryGynecologicHead & NeckOther hematologic neoplasmThoracic

67 enrolled 9 charts

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Tobacco Use Disorder, Leukemia, Myeloid, Acute, Small Cell Lung Carcinoma

NCT01553851 2016-12-26

GSK1120212 in Surgically Resectable Oral Cavity Squamous Cell Cancer

20 enrolled 13 charts

Mouth Neoplasms

NCT00537199 2016-05-13

OraTest in Combination With Visual Examination and Visual Examination Alone

Phase 3 Terminated

1 enrolled 2 charts

GastrointestinalGenitourinaryGynecologicHead & NeckOther hematologic neoplasmThoracic

Head and Neck Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT00365508 2016-03-29

Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking

Phase 4 Completed

642 enrolled 8 charts

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Tobacco Use Disorder, Tongue Neoplasms, Leukemia, Myeloid, Acute, Small Cell Lung Carcinoma

NCT00330382 2014-12-19

Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia

325 enrolled 15 charts

Leukoplakia, Oral, Mouth Neoplasms, Oropharyngeal Neoplasms, Tongue Neoplasms

NCT00530088 2014-07-04

Photodynamic Therapy Using Porfimer Sodium in Treating Patients With Recurrent Mouth or Throat Dysplasia or Recurrent In Situ Cancer or Stage I Cancer of the Mouth or Throat

Phase NA Terminated

30 enrolled 8 charts