Clinical Trials

100 enrolled

Mouth Neoplasms

NCT06997068 2026-04-03

Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Oral Cavity Cancer in a Rural Midwest United States Population

25 enrolled

Mouth Neoplasms

NCT07343596 2026-03-24

Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery

20 enrolled

Mouth Neoplasms

NCT07209189 2026-03-09

(NeoScorch HN)

75 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT06627270 2026-03-05

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Mouth Neoplasms

NCT06868433 2026-03-04

TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer

Phase 1 Recruiting

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Recurrence

NCT06798922 2026-03-03

OPTIFLAP

Phase 3 Recruiting

348 enrolled

Mouth Neoplasms

NCT06336941 2026-02-25

HOUSTON

400 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT05837221 2026-02-24

Microbiome in Head and Neck Squamous Cell Carcinoma

60 enrolled

Head and Neck Neoplasms, Lip Neoplasms, Mouth Neoplasms, Pharyngeal Neoplasms

NCT07063212 2026-02-19

A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)

Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07110142 2026-02-13

T-PROSE

Head and Neck Neoplasms, Mouth Neoplasms

NCT01269190 2026-02-11

Wide-Field and High Resolution In Vivo Imaging in Visualizing Lesions in Patients With Oral Neoplasia Undergoing Surgery

275 enrolled

Mouth Neoplasms

NCT06629038 2026-02-11

Estimating Jaw, Neck, and Shoulder Range of Motion Using an AI Model

Mouth Neoplasms

NCT06636734 2026-02-11

Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial

28 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT01473784 2026-02-10

Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck

600 enrolled

Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Tongue Neoplasms

NCT07401641 2026-02-10

Effect of Dezocine Versus Nalbuphine Combined With Sufentanil on Postoperative Analgesia, Complications, and Free Flap Survival in Patients Undergoing Oral Cancer Radical Surgery: A Randomized Controlled Clinical Trial.

60 enrolled

Mouth Neoplasms

NCT07387978 2026-02-04

PBM

30 enrolled

Head and Neck Neoplasms, Mouth Neoplasms, Stomatitis

NCT02012699 2026-01-22

iCaRe2

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther hematologic neoplasmOther solid neoplasmPlasma cellSarcomaThoracic

999,999 enrolled

Anus Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Duodenal Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Lip Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Mesothelioma, Mouth Neoplasms, Multiple Myeloma, Nasopharyngeal Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Paranasal Sinus Neoplasms, Paraproteinemias, Penile Neoplasms, Peritoneal Neoplasms, Adenomatous Polyposis Coli, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Sarcoma, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Ureteral Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Central Nervous System Neoplasms, Thyroid Nodule, Endometrial Neoplasms, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors

NCT07296250 2025-12-22

Circulating Tumor Cell Counts in Postoperative ENE-Positive Oral Cavity Cancer Patients After Adjuvant CCRT

100 enrolled

Head and Neck Neoplasms, Mouth Neoplasms, Neoplastic Cells, Circulating

NCT07237672 2025-12-16

AI Based Physiotherapy 3- and 9-Month Follow-Up in Oral Cancer Patients

65 enrolled

Mouth Neoplasms

NCT06682494 2025-12-12

Enhancing Oral Cancer Awareness

60 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05793151 2025-12-11

ENDURE

532 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT06448026 2025-12-05

Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity Squamous Cell Carcinoma (OCSCC).

17 enrolled

Mouth Neoplasms

NCT07095608 2025-11-21

Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain

80 enrolled

Carcinoma, Squamous Cell, Mouth Neoplasms

NCT04265430 2025-11-14

Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors

Phase 4 Recruiting

425 enrolled

Phase EARLY_PHASE1 Recruiting

Mouth Neoplasms, Osteoradionecrosis

NCT06819228 2025-10-03

Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer

18 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Mouth Neoplasms, Tongue Neoplasms

NCT06915454 2025-10-03

High-Resolution PET-CT Imaging for Surgical Margin Visualization

50 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Mouth Neoplasms, Neoplasms, Tongue Neoplasms

NCT07203911 2025-10-02

SURGIO

200 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Tongue Neoplasms

NCT00900419 2025-09-22

Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers

GastrointestinalHead & NeckOther neoplasmThoracic

700 enrolled

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Lung Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Precancerous Conditions, Salivary Gland Neoplasms, Tongue Neoplasms, Small Cell Lung Carcinoma

NCT07180901 2025-09-18

PRONTO-HN

85 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT05757817 2025-09-15

LAMBEAU STEPA

Head and Neck Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05973656 2025-08-22

Role of Acetaldehyde in the Development of Oral Cancer

Classical hematologyHead & Neck

170 enrolled

Fanconi Anemia, Mouth Neoplasms

NCT07121595 2025-08-13

Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial

50 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT05429099 2025-07-24

ViPMR

Phase 2/3 Recruiting

420 enrolled

Mouth Neoplasms

NCT05740033 2025-06-12

Radial Forearm Donor Site Closure

120 enrolled

Mouth Neoplasms

NCT05030597 2025-05-28

FAPI-OSCC

100 enrolled

Mouth Neoplasms

NCT06321003 2025-05-23

SYMILIS OCT

200 enrolled

DermatologicHead & Neck

Actinic cheilitis, Squamous Cell Carcinoma of Head and Neck, Graft vs Host Disease, Leukoplakia, Oral, Mouth Diseases, Mouth Neoplasms, Lichen Planus, Oral, Keratosis, Actinic

NCT06681935 2025-05-21

Defining Mechanisms of Surgical Site Infection After Oral Cancer Surgery

Mouth Neoplasms, Surgical Wound Infection

NCT02584270 2025-05-16

PGSRT

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Mouth Neoplasms, Tongue Neoplasms

NCT06673329 2025-05-14

Brodalumab in the Treatment of Immune-Related Adverse Events

Phase 1 Recruiting

11 enrolled

Brain Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms

NCT06934863 2025-04-18

LPO_CMR

300 enrolled

Mouth Neoplasms, Lichen Planus, Oral

NCT04809324 2025-04-11

Gross Examinations Versus Frozen Section for Assessment of Surgical Margins in Oral Cancers

1,206 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT06662058 2025-04-10

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

118 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05337631 2025-03-25

SENIOR

1,500 enrolled

Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05784012 2025-03-13

RADIAN

Phase 1/2 Recruiting

34 enrolled