Clinical Trials

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT04265430 2026-05-22

Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors

Phase 4 Recruiting

425 enrolled

Mouth Neoplasms, Osteoradionecrosis

NCT02253238 2026-05-20

Sensor-Assisted Prevention of Dehydration in Head and Neck Cancer Patients

427 enrolled

Dehydration, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms

NCT06448026 2026-05-20

Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity Squamous Cell Carcinoma (OCSCC).

17 enrolled

BreastCNSGenitourinaryHead & NeckLymphoidMyeloidSarcoma

Mouth Neoplasms

NCT01552434 2026-05-15

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Phase 1 Terminated

154 enrolled

Breast Neoplasms, Carcinoma, Transitional Cell, Endocrine Gland Neoplasms, Castleman Disease, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms, Pharyngeal Neoplasms, Recurrence, Sarcoma, Soft Tissue Neoplasms, Thyroid Neoplasms, Urologic Neoplasms, Neurofibromatosis 2, Lymphangioleiomyomatosis, Neoplasms, Mesothelial, Erdheim-Chester Disease

NCT06673329 2026-05-13

Brodalumab in the Treatment of Immune-Related Adverse Events

Phase 1 Recruiting

11 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Brain Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Mouth Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thyroid Neoplasms

NCT07203911 2026-05-13

SURGIO

150 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Tongue Neoplasms

NCT06997068 2026-05-11

Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population

25 enrolled

Carcinoma, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT02584270 2026-05-08

PGSRT

Mouth Neoplasms, Tongue Neoplasms

NCT06682494 2026-05-08

Enhancing Oral Cancer Awareness

60 enrolled

Phase EARLY_PHASE1 Recruiting

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT06819228 2026-05-08

Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer

18 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Mouth Neoplasms, Tongue Neoplasms

NCT06915454 2026-05-08

High-Resolution PET-CT Imaging for Surgical Margin Visualization

50 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Mouth Neoplasms, Neoplasms, Tongue Neoplasms

NCT06231537 2026-05-07

Visual Oral Examination for Early Detection of Oral Cancer in High-Risk Individuals

1,152 enrolled

Disease, Mouth Neoplasms

NCT07110142 2026-05-07

T-PROSE

Head and Neck Neoplasms, Mouth Neoplasms

NCT04333537 2026-05-04

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Phase 2/3 Recruiting

686 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT06532279 2026-05-04

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

98 enrolled

Phase 3 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Stomatitis

NCT07441681 2026-05-04

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

454 enrolled

Phase 1/2 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07552558 2026-04-27

Ficerafusp Alfa, Pembrolizumab, and Stereotactic Body Radiotherapy (SBRT) for Head and Neck Squamous Cell Carcinoma (HNSCC)

45 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Jaw Neoplasms, Laryngeal Neoplasms, Lip Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Tongue Neoplasms

NCT06662058 2026-04-23

Remote Audiometry to Monitor for Treatment-Related Hearing Loss in Patients With H&N SCC Receiving Cisplatin and/or Radiation

118 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07209189 2026-04-23

(NeoScorch HN)

75 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT07343596 2026-04-22

Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery

20 enrolled

Phase NA Not yet recruiting

Mouth Neoplasms

NCT07538934 2026-04-20

A Phase II Prospective, Open-Label, Randomized, Multicenter Study of Kangfu Spray for the Prevention of Radiation-Induced Oral Mucositis in Patients With Oral Malignancies Receiving Intensity-Modulated Radiotherapy

140 enrolled

Phase EARLY_PHASE1 Active not recruiting

Mouth Neoplasms

NCT02790853 2026-04-15

Multimodal Imaging for Surveillance in Patients With Oral Potentially Malignant Disorders

63 enrolled

Mouth Diseases, Mouth Neoplasms

NCT04870762 2026-04-15

Customized 3D Printed Oral Stents During Head and Neck Radiotherapy

119 enrolled

Phase 2 Active not recruiting

Maxillary Sinus Neoplasms, Mouth Neoplasms, Parotid Neoplasms, Tongue Neoplasms, Tonsillar Neoplasms

NCT05075980 2026-04-13

Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study

174 enrolled

Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Lymphatic Metastasis, Mouth Neoplasms, Oropharyngeal Neoplasms, Paranasal Sinus Neoplasms, Salivary Gland Neoplasms

NCT00540774 2026-04-09

Optical Sensor for Photodynamic Detection of Oral Pathology

1,004 enrolled

Phase 2 Not yet recruiting

Gingivitis, Mouth Diseases, Mouth Neoplasms, Periodontitis, Stomatitis, Xerostomia

NCT07518485 2026-04-08

preReDSeL

20 enrolled

Mouth Neoplasms

NCT06785051 2026-04-03

AI-based Physiotherapy for Oral Cancer Patients

100 enrolled

Mouth Neoplasms

NCT06874985 2026-04-03

Effectiveness and Impact of the Lived Experience Cancer Awareness Campaign on Screening Participation

BreastGynecologicHead & Neck

1,120 enrolled

Breast Neoplasms, Uterine Cervical Neoplasms, Mouth Neoplasms

NCT03420963 2026-03-20

Donor Natural Killer Cells, Cyclophosphamide, and Etoposide in Treating Children and Young Adults With Relapsed or Refractory Solid Tumors

Phase 1 Terminated

12 enrolled

DermatologicGenitourinaryHead & NeckOther solid neoplasmSarcomaThoracic

Mesothelioma, Malignant, Bone Neoplasms, Endocrine Gland Neoplasms, Melanoma, Mouth Neoplasms, Pharyngeal Neoplasms, Sarcoma, Skin Neoplasms, Thyroid Neoplasms, Urologic Neoplasms

NCT07466810 2026-03-20

Resection and Defect Repair of Oral Cancer Aided by Mixed Reality Technology

Phase NA Not yet recruiting

30 enrolled

Phase 2 Not yet recruiting

Mouth Neoplasms

NCT06876038 2026-03-19

Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions

65 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma in Situ, Leukoplakia, Oral, Mouth Neoplasms, Lichen Planus, Oral

NCT04251949 2026-03-18

MuciLight

Phase 2 Completed

28 enrolled

Head & NeckOther

Mouth Neoplasms, Oropharyngeal Neoplasms, Mucositis

NCT01198119 2026-03-16

NBI-CAB

Phase 2 Terminated

23 enrolled

Phase 1 Not yet recruiting

Mouth Neoplasms, Neoplasms

NCT07460765 2026-03-10

Safety and Feasibility of Nivolumab-IRDye800CW in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Mouth Neoplasms, Neoplasms, Squamous Cell

NCT00542373 2026-03-05

Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer

Classical hematologyDermatologicHead & Neck

338 enrolled

Erythroplasia, Fanconi Anemia, Lichen Planus, Mouth Neoplasms, Tobacco Use Disorder, Leukokeratosis, Hereditary Mucosal

NCT06627270 2026-03-05

Antibiotic Treatment Effects on Intratumoral Bacteria Modulation in Surgical Patients With Oral Cancer

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Mouth Neoplasms

NCT06868433 2026-03-04

TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer

Phase 1 Recruiting

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Recurrence

NCT06798922 2026-03-03

OPTIFLAP

Phase 3 Recruiting

348 enrolled

Mouth Neoplasms

NCT02589938 2026-02-27

ACUPUNCTURE

258 enrolled 16 charts

Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Radiation Injuries, Salivary Gland Neoplasms, Xerostomia

NCT05316688 2026-02-25

A Fluorescent Tumor Marking Agent, Tozuleristide, for Imaging Oral Cavity Squamous Cell Cancer and High-Grade Oral Cavity Dysplasia During Surgery

Phase 1/2 Terminated

8 enrolled

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT06336941 2026-02-25

HOUSTON

400 enrolled

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT03174275 2026-02-23

Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

39 enrolled 8 charts

GastrointestinalHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Esophageal Neoplasms, Laryngeal Neoplasms, Lip Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT04713449 2026-02-23

Enhancing Self Care Among Oral Cancer Survivors: The Empowered Survival Trial

643 enrolled

Head and Neck Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT04372914 2026-02-20

Prevention of Oral DNA Damage by Black Raspberries

69 enrolled 14 charts

Mouth Neoplasms, Smoking

NCT07063212 2026-02-19

A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)

Phase NA Not yet recruiting

Squamous Cell Carcinoma of Head and Neck, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07413627 2026-02-18

BaReTox

70 enrolled

GastrointestinalHead & Neck

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT03993353 2026-02-12

Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer

Phase 2 Completed

7 enrolled 14 charts

Pyridoxine-dependent epilepsy, Parkinson Disease 4, Autosomal Dominant Lewy Body, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Esophageal Neoplasms, Head and Neck Neoplasms, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms

NCT01269190 2026-02-11

Wide-Field and High Resolution In Vivo Imaging in Visualizing Lesions in Patients With Oral Neoplasia Undergoing Surgery

275 enrolled

Mouth Neoplasms

NCT06636734 2026-02-11

Lovastatin and Pembrolizumab for the Treatment of Patients With Recurrent or Metastatic Head and Neck Cancer, LAPP Trial

28 enrolled