Announcements Trials
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Phase

Phase 2 2

Status

Suspended 1Active not recruiting 1

Sponsor Class

NIH 2

Study Type

Interventional 2

Sponsor

Cancer Type

Myeloid 2Other hematologic neoplasm 1Classical hematology 1

Conditions

Leukemia, Myeloid, Acute 8Myelodysplastic Syndromes 5Myeloproliferative Disorders 3Leukemia, Myelomonocytic, Chronic 3Myelodysplastic-Myeloproliferative Diseases 2Thrombocythemia, Essential 1Primary Myelofibrosis 1Polycythemia Vera 1Neurofibrosarcoma 1Neoplasms 1Mesothelioma, Malignant 1Mesothelioma 1Leukemia, Myeloid, Chronic-Phase 1Leukemia, Biphenotypic, Acute 1Anemia, Refractory, with Excess of Blasts 1Allogeneic Stem Cell Transplantation 1Accelerated Phase Myeloproliferative Neoplasm 1

Interventions

Cyclophosphamide 27Busulfan 25fludarabine phosphate 24Antilymphocyte Serum 20Tacrolimus 18Peripheral Blood Stem Cell Transplantation 18Cyclosporine 15Radiotherapy 14Mycophenolic Acid 14Methotrexate 14Melphalan 12Filgrastim 11Whole-Body Irradiation 10Methylprednisolone 10Cord Blood Stem Cell Transplantation 9Etoposide 7Cytarabine 5sargramostim 4Thiotepa 4Thalidomide 4Specimen Handling 4Sirolimus 4Rituximab 4Cyclosporins 4Biopsy 4Alemtuzumab 4ruxolitinib 3Flow Cytometry 3Arsenic Trioxide 3thymoglobulin 2

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Phase 2 × Myelodysplastic-Myeloproliferative Diseases × decitabine and cedazuridine drug combination × Clear all
NCT06661915 2026-05-29

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

National Cancer Institute (NCI)

Phase 2 Suspended
62 enrolled
Myeloid

Myeloproliferative Disorders, Polycythemia Vera, Thrombocythemia, Essential, Myelodysplastic-Myeloproliferative Diseases, Primary Myelofibrosis

NCT05600894 2026-05-13

Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm

National Cancer Institute (NCI)

Phase 2 Active not recruiting
132 enrolled
Classical hematologyMyeloidOther hematologic neoplasm

Anemia, Refractory, with Excess of Blasts, Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Myelomonocytic, Chronic, Myelodysplastic-Myeloproliferative Diseases

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