Announcements Trials
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Phase

Phase 2 2

Status

Suspended 1Active not recruiting 1

Sponsor Class

NIH 2

Study Type

Interventional 2

Sponsor

Cancer Type

Myeloid 2Other hematologic neoplasm 1Classical hematology 1

Conditions

Leukemia, Myeloid, Acute 9Myelodysplastic Syndromes 5Myeloproliferative Disorders 3Myelodysplastic-Myeloproliferative Diseases 2Triple Negative Breast Neoplasms 1Thrombocythemia, Essential 1Primary Myelofibrosis 1Polycythemia Vera 1Mesothelioma, Malignant 1Mesothelioma 1Lymphoma, Large B-Cell, Diffuse 1Lymphoma, B-Cell 1Leukemia, Myelomonocytic, Chronic 1Hodgkin Disease 1GATA2 Deficiency 1Anemia, Refractory, with Excess of Blasts 1

Interventions

fludarabine phosphate 6Cytarabine 5Peripheral Blood Stem Cell Transplantation 4Filgrastim 3Etoposide 3Cyclophosphamide 3Busulfan 3Biopsy 3romidepsin 2perifosine 2laromustine 2decitabine and cedazuridine drug combination 2Tretinoin 2Specimen Handling 2Methotrexate 2Hydroxyurea 2Decitabine 2Daunorubicin 2Cyclosporine 2Antilymphocyte Serum 2venetoclax 1veliparib 1valspodar 1octadecyl-(N,N-dimethylpiperidino-4-yl)-phosphate 1iadademstat 1gamma-Globulins 1Voriconazole 1Vincristine 1Topotecan 1Thiotepa 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
NIH × Myelodysplastic-Myeloproliferative Diseases × decitabine and cedazuridine drug combination × Clear all
NCT06661915 2026-05-29

A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)

National Cancer Institute (NCI)

Phase 2 Suspended
62 enrolled
Myeloid

Myeloproliferative Disorders, Polycythemia Vera, Thrombocythemia, Essential, Myelodysplastic-Myeloproliferative Diseases, Primary Myelofibrosis

NCT05600894 2026-05-13

Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm

National Cancer Institute (NCI)

Phase 2 Active not recruiting
132 enrolled
Classical hematologyMyeloidOther hematologic neoplasm

Anemia, Refractory, with Excess of Blasts, Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Myelomonocytic, Chronic, Myelodysplastic-Myeloproliferative Diseases

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