NCT04784715 2026-02-20Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)AstraZenecaPhase 3 Active not recruiting1,157 enrolled 3 FDA
NCT00781612 2025-12-24A Safety Extension Study of Trastuzumab Emtansine in Participants Previously Treated With Trastuzumab Emtansine Alone or in Combination With Other Anti-Cancer Therapy in One of the Parent StudiesGenentech, Inc.Phase 2 Active not recruiting720 enrolled
NCT00393783 2025-06-05Xenogeneic HER2/Neu DNA Immunization for Patients With Metastatic and High Risk Breast Cancer: A Phase I Study to Assess Safety and ImmunogenicityMemorial Sloan Kettering Cancer CenterPhase 1 Active not recruiting13 enrolled