Clinical Trials

Classical hematologyGenitourinary

35 enrolled

Neoplasms, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms, Venous Thromboembolism

NCT03158064 2026-01-28

Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors

Phase 2 Active not recruiting

30 enrolled

Nonseminomatous germ cell tumor, Dysgerminoma, Neoplasms, Germ Cell and Embryonal, Germinoma, Seminoma

NCT04876456 2026-01-15

A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

Phase 2 Active not recruiting

50 enrolled

Nonseminomatous germ cell tumor, Neoplasms, Germ Cell and Embryonal, Seminoma

NCT05634785 2026-01-09

CD30 CAR for CD30+ NSGCT

2 enrolled

Nonseminomatous germ cell tumor, Neoplasms, Germ Cell and Embryonal

NCT07188441 2025-09-23

Treatment of Newly Diagnosed Central Malignant Germ Cell Tumor People With Teniposide Injection Combined With Cisplatin.

40 enrolled

Neoplasms, Germ Cell and Embryonal

NCT06470464 2025-09-18

Thalidomide Combined With Chemotherapy in the Treatment of Relapsed or Refractory Yolk Sac Tumor

20 enrolled

Neoplasms, Germ Cell and Embryonal, Recurrence, Endodermal Sinus Tumor

NCT07121322 2025-08-13

DACT-GCT

33 enrolled

Neoplasms, Germ Cell and Embryonal

NCT06418789 2025-08-03

GERMAN

Phase 2 Active not recruiting

25 enrolled

Nonseminomatous germ cell tumor, Choriocarcinoma, Neoplasms, Germ Cell and Embryonal, Teratoma, Germinoma, Seminoma, Endodermal Sinus Tumor

NCT01873326 2025-07-03

Paclitaxel, Ifosfamide and Cisplatin (TIP) Versus Bleomycin, Etoposide and Cisplatin (BEP) for Patients With Previously Untreated Intermediate- and Poor-risk Germ Cell Tumors

92 enrolled

Neoplasms, Germ Cell and Embryonal

NCT06940804 2025-07-02

AVENTURINE

Testicular Germ Cell Tumor, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms

NCT04743310 2025-06-13

Fluorescence Detection of Adult Primary Central Nervous System Tumors With Tozuleristide and the Canvas System

50 enrolled

CNS

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Meningioma, Neoplasms, Germ Cell and Embryonal, Neuroma, Acoustic, Pinealoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms

NCT04804007 2025-04-18

Maintenance Oral Etoposide or Observation Following High-dose Chemo for GCT

64 enrolled

Nonseminomatous germ cell tumor, Neoplasms, Germ Cell and Embryonal

NCT02533765 2025-01-30

Olaparib as Salvage Treatment for Cisplatin-resistant Germ Cell Tumor

18 enrolled

Neoplasms, Germ Cell and Embryonal

NCT04791228 2025-01-01

A Pilot Study of Thermodox and MR-HIFU for Treatment of Relapsed Solid Tumors

GastrointestinalGenitourinarySarcoma

Carcinoma, Carcinoma, Hepatocellular, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Recurrence, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing

NCT01782339 2024-06-14

GAMMA

45 enrolled

Neoplasms, Germ Cell and Embryonal

NCT02624388 2024-05-06

UVA-Gen001

CNSGenitourinaryLymphoidSarcoma

4 enrolled 16 charts

Brain Neoplasms, Hodgkin Disease, Lymphoma, Lymphoma, Non-Hodgkin, Medulloblastoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Neuroectodermal Tumors, Primitive

NCT02340884 2024-04-09

A Pilot RCT of the PRISM Intervention for AYAs With Cancer

CNSLymphoidOther hematologic neoplasmSarcoma

92 enrolled

Brain Neoplasms, Lymphoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Sarcoma, Leukemia, Myeloid, Acute, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT06309732 2024-03-13

GAMEC-II

36 enrolled

Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms

NCT03012620 2024-02-28

AcSé

CNSEndocrineGynecologicHead & NeckLymphoidSarcoma

334 enrolled

Neoplasms, Germ Cell and Embryonal, Ovarian Neoplasms, Sarcoma, Thyroid Neoplasms, Central Nervous System Neoplasms, Carcinoma, Neuroendocrine, Lymphoma, Extranodal NK-T-Cell

NCT03950830 2023-10-04

DISGCT

12 enrolled

Neoplasms, Germ Cell and Embryonal

NCT03194906 2023-07-13

Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors

34 enrolled

CNS

Brain Neoplasms, Craniopharyngioma, Ependymoma, Neoplasms, Germ Cell and Embryonal

NCT02499952 2022-07-11

Pembrolizumab in Subjects With Incurable Platinum-Refractory Germ Cell Tumors

12 enrolled 14 charts

GenitourinaryGynecologic

Nonseminomatous germ cell tumor, Genital Neoplasms, Female, Genital Neoplasms, Male, Mediastinal Neoplasms, Neoplasms, Germ Cell and Embryonal, Ovarian Neoplasms, Testicular Neoplasms

NCT01743482 2021-05-14

Pazotest-01

43 enrolled

Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms

NCT03081923 2021-05-14

APACHE

36 enrolled

Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms

NCT02988843 2020-12-10

Study of Brentuximab Vedotin And Bevacizumab In Refractory CD-30 Positive Germ Cell Tumors

1 enrolled 8 charts

Neoplasms, Germ Cell and Embryonal

NCT02300987 2020-10-26

A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression

10 enrolled 12 charts

Neoplasms, Germ Cell and Embryonal, Teratoma

NCT02414685 2020-08-07

TIP

19 enrolled

Neoplasms, Germ Cell and Embryonal

NCT00179803 2020-08-05

Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors

24 enrolled

CNS

Astrocytoma, Brain Neoplasms, Glioblastoma, Medulloblastoma, Neoplasms, Germ Cell and Embryonal, Pinealoma, Supratentorial Neoplasms, Central Nervous System Neoplasms, Rhabdoid Tumor

NCT02689219 2019-12-10

Brentuximab Vedotin in Relapsed/Refractory Germ Cell Tumors

18 enrolled 13 charts

Nonseminomatous germ cell tumor, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms, Carcinoma, Embryonal

NCT03726281 2019-08-21

Nivolumab in Platinum Recurrent or Refractory Metastatic Germ Cell Tumors

Neoplasms, Germ Cell and Embryonal

NCT01966809 2019-08-20

Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas

1 enrolled 5 charts

CNSEndocrineSarcoma

Astrocytoma, Brain Neoplasms, Chordoma, Craniopharyngioma, Glioblastoma, Glioma, Meningioma, Neoplasms, Germ Cell and Embryonal, Oligodendroglioma, Pituitary Neoplasms, Germinoma, Optic Nerve Glioma

NCT03960151 2019-05-22

Rolapitant Plus Olanzapine in Multiday Cisplatin Chemotherapy

Neoplasms, Germ Cell and Embryonal

NCT03403777 2019-03-05

Avelumab in Refractory Testicular Germ Cell Cancer.

8 enrolled

Gonadal Disorders, Neoplasms, Neoplasms, Germ Cell and Embryonal, Testicular Diseases, Testicular Neoplasms

NCT01962896 2019-02-26

A Phase II Study of Sirolimus and Erlotinib in Recurrent/Refractory Germ Cell Tumors

4 enrolled 6 charts

Neoplasms, Germ Cell and Embryonal

NCT01851200 2018-02-07

Brentuximab Vedotin (SGN-35) as Salvage Treatment for CD30-positive Germ Cell Tumors

9 enrolled

Neoplasm Metastasis, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms, Carcinoma, Embryonal

NCT01177007 2017-08-28

Intra-arterial Y-90 TheraSpheres for Hepatic Metastases From Solid Tumors

EndocrineGastrointestinalNET

50 enrolled 10 charts

Adenocarcinoma, Carcinoma, Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Liver Diseases, Liver Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Neoplastic Processes, Pathologic Processes, Rectal Diseases, Colorectal Neoplasms, Neuroectodermal Tumors, Carcinoma, Neuroendocrine, Neuroendocrine Tumors

NCT00183820 2017-07-07

Study of Gemcitabine, Oxaliplatin, and Paclitaxel in Patients With Refractory Germ Cell Carcinoma

30 enrolled

Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms

NCT01736917 2016-05-25

Fosaprepitant + 5HT3 Receptor Antagonists + Dexamethasone in Germ Cell Tumors

65 enrolled 14 charts

Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms, Vomiting

NCT00912912 2016-04-15

Sunitinib Malate in Refractory Germ Cell Tumors

5 enrolled 6 charts

Urogenital Diseases, Neoplasms, Germ Cell and Embryonal

NCT00393861 2016-03-24

Study of Oxaliplatin Plus Bevacizumab in Germ Cell Tumor Patients

29 enrolled 10 charts

Neoplasms, Germ Cell and Embryonal

NCT01466231 2016-01-12

Everolimus in Refractory Testicular Germ Cell Cancer

15 enrolled

Neoplasms, Germ Cell and Embryonal

NCT01215578 2015-04-30

NET

EndocrineGastrointestinalNET

33 enrolled

Adenocarcinoma, Adenoma, Carcinoma, Digestive System Diseases, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Adenoma, Islet Cell, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Pancreatic Diseases, Pancreatic Neoplasms, Neuroectodermal Tumors, Neuroendocrine Tumors

NCT01242631 2015-02-25

RADIT

25 enrolled

Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms

NCT00198159 2014-09-19

IUCRO-0021

21 enrolled

Neoplasms, Germ Cell and Embryonal

NCT02161692 2014-06-12

Conventional Dose Versus High Dose Sequential Chemotherapy for Poor Prognosis Germ Cell Tumors

Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms

NCT00198172 2014-06-03

Phase II Study of Cisplatin Plus Epirubicin Salvage Chemo in Refractory Germ Cell Tumors

37 enrolled

Neoplasms, Germ Cell and Embryonal

NCT00371553 2009-07-08

Phase-II Study of SU011248 (Sunitinib)in Male Patients With Relapsed or Cisplatin-Refractory Germ Cell Cancer

33 enrolled

Neoplasms, Germ Cell and Embryonal, Recurrence

NCT00772694 2008-10-24

GCT

Phase 2 Unknown

20 enrolled