Clinical Trials

35 enrolled 11 charts

Carcinoma, Neoplasms, Neoplasms, Unknown Primary

NCT02713269 2026-04-17

Thermal Ablation and Spine Stereotactic Radiosurgery in Treating Patients With Spine Metastases at Risk for Compressing the Spinal Cord

DermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

60 enrolled

Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Neoplasms, Unknown Primary, Sarcoma, Spinal Cord Compression, Thyroid Neoplasms

NCT05576974 2026-04-14

A Phase 2a, Single-dose, Open-label Study to Evaluate Diagnostic Performance and Safety of Pegsitacianine, an Intraoperative Fluorescence Imaging Agent for the Detection of Cancer, in Patients With Unknown Primary Head and Neck Cancer (ILLUMINATE STUDY)

Phase 2 Recruiting

120 enrolled

Phase 1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Unknown Primary

NCT01366144 2026-04-13

Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction

94 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Breast Neoplasms, Carcinoma, Transitional Cell, Esophageal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Unknown Primary, Ovarian Neoplasms, Testicular Neoplasms, Endometrial Neoplasms, Liver Failure, Renal Insufficiency

NCT04475640 2026-04-02

Cancer Genetic Testing in Ethnic Populations

Phase NA Recruiting

1,800 enrolled

BreastCNS

Brain Neoplasms, Breast Neoplasms, Neoplasms, Unknown Primary

NCT05024968 2026-02-25

Sintilimab in Cancer of Unknown Primary

10 enrolled 9 charts

Phase 1 Active not recruiting

Neoplasms, Unknown Primary

NCT04459273 2026-02-05

FAPI PET RDRC

26 enrolled

CNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther hematologic neoplasm

Adrenal Gland Neoplasms, Urinary Bladder Neoplasms, Brain Neoplasms, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Neoplasms, Unknown Primary, Skin Neoplasms, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Cholangiocarcinoma, Neuroendocrine Tumors, Hematologic Neoplasms

NCT02721732 2026-01-29

Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic

CNSEndocrineGenitourinary

157 enrolled 26 charts

Adrenal Cortex Neoplasms, Carcinoma, Renal Cell, Neoplasm Metastasis, Neoplasms, Unknown Primary, Paraganglioma, Penile Neoplasms, Pheochromocytoma, Carcinoma, Small Cell, Vascular Neoplasms

NCT07366008 2026-01-26

NorCUP

Phase NA Not yet recruiting

350 enrolled

Neoplasms, Unknown Primary

NCT03498521 2025-11-19

CUPISCO

529 enrolled 16 charts

BreastDermatologicGastrointestinalHead & NeckSarcomaThoracic

Neoplasms, Unknown Primary

NCT04273061 2025-09-22

CAPTIV-8

Phase 2 Recruiting

200 enrolled

Breast Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Neoplasms, Unknown Primary, Sarcoma, Skin Neoplasms, Urogenital Neoplasms

NCT03391973 2025-04-25

CUP

26 enrolled

Neoplasms, Unknown Primary

NCT04802876 2025-03-21

ACROPOLI

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther solid neoplasmSarcomaThoracic

184 enrolled

Adenocarcinoma Of Esophagus, Adenocarcinoma of Lung, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Uveal Melanoma, Anus Neoplasms, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Melanoma, Mesothelioma, Neoplasms, Unknown Primary, Sarcoma, Thyroid Neoplasms, Cholangiocarcinoma, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT04584008 2024-10-15

VISIONARY

Phase NA Active not recruiting

600 enrolled

EndocrineGastrointestinalNETSarcoma

Esophageal Squamous Cell Carcinoma, Biliary Tract Neoplasms, Gastrointestinal Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors

NCT05841966 2024-05-07

OP-CUP

Phase NA Completed

30 enrolled

GenitourinaryGynecologicHead & Neck

Carcinoma, Squamous Cell, Neoplasms, Unknown Primary

NCT03418480 2024-02-07

HARE-40

Phase 1/2 Completed

32 enrolled

Uterine Cervical Neoplasms, Head and Neck Neoplasms, Neoplasms, Unknown Primary, Penile Neoplasms

NCT02607202 2024-01-26

AGNOSTOS

57 enrolled

Neoplasms, Unknown Primary

NCT06100081 2023-10-25

REFLECT

Phase NA Unknown

35 enrolled

Neoplasms, Unknown Primary, Oropharyngeal Neoplasms

NCT04456140 2023-07-24

Pro-Active Genetic Testing in Patients With Solid Tumors, Inherit Study

BreastCNSGastrointestinalHead & Neck

230 enrolled

Brain Neoplasms, Breast Neoplasms, Digestive System Neoplasms, Head and Neck Neoplasms, Neoplasms, Unknown Primary, Urogenital Neoplasms, Central Nervous System Neoplasms

NCT00499291 2023-05-25

Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced or Refractory Solid Tumors

Phase NA Withdrawn

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Teratoma, Testicular, Teratoma, Ovarian, Carcinoma, Ovarian Epithelial, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Fallopian Tube Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Stomach Neoplasms, Teratoma, Testicular Neoplasms, Endometrial Neoplasms, Small Cell Lung Carcinoma

NCT01845337 2023-05-12

TOFFEE

59 enrolled

Bile Duct Neoplasms, Gastrointestinal Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms

NCT05263700 2023-03-31

FAPI-CUP

Phase NA Unknown

150 enrolled

Neoplasms, Unknown Primary

NCT04189107 2023-03-16

Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP & OSAS

18 enrolled

CNSDermatologicEndocrineNET

Agnosia, Head and Neck Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Pain, Postoperative

NCT04276597 2023-03-10

PUTNET

Phase 2 Withdrawn

Neoplasms, Unknown Primary, Paraganglioma, Pheochromocytoma, Carcinoma, Merkel Cell, Neuroendocrine Tumors

NCT03053466 2022-05-09

APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors

30 enrolled

Turcot syndrome, Neoplasms, Unknown Primary, Microsatellite Instability

NCT03278600 2022-01-24

Tissue-of-origin Directing Therapy in Patients With Cancer of Unknown Primary

182 enrolled

Neoplasms, Unknown Primary

NCT00003526 2020-12-17

Antineoplaston Therapy in Treating Patients With Cancer of Unknown Primary Origin

Phase 2 Terminated

8 enrolled 5 charts

Neoplasms, Unknown Primary

NCT00357630 2020-11-02

Gemcitabine in Treating Patients With Metastatic Cancer of Unknown Primary

52 enrolled

Neoplasms, Unknown Primary, Pain

NCT01643499 2020-05-08

Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies

79 enrolled

Bile Duct Neoplasms, Colonic Neoplasms, Gallbladder Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT04131621 2020-04-15

CheCUP

Phase 2 Unknown

194 enrolled

Neoplasms, Unknown Primary

NCT01540058 2020-02-17

GEFCAPI04

243 enrolled

Neoplasms, Unknown Primary

NCT03628079 2020-01-22

RepoMeb

Phase 1/2 Terminated

11 enrolled

Gastrointestinal Neoplasms, Neoplasms, Unknown Primary

NCT02764216 2019-04-09

Elective Mucosal Irradiation in Head-and-Neck Cancer of Unknown Primary

Phase 2 Unknown

48 enrolled

Phase EARLY_PHASE1 Terminated

Head and Neck Neoplasms, Neoplasms, Unknown Primary

NCT00499733 2019-01-18

Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer

19 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckLymphoidSarcomaThoracic

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Chondrosarcoma, Colonic Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Osteosarcoma, Tongue Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Esthesioneuroblastoma, Olfactory, Breast Neoplasms, Male, Small Cell Lung Carcinoma, Intraocular Lymphoma

NCT02966509 2018-10-31

EPAC

Phase NA Completed

213 enrolled 20 charts

CNSDermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Colonic Neoplasms, Death, Glioblastoma, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Unknown Primary, Prostatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms, Testicular Neoplasms

NCT00003867 2018-09-10

Irinotecan and Capecitabine in Treating Patients With Solid Tumors

30 enrolled

BreastGastrointestinal

Anus Neoplasms, Appendiceal Neoplasms, Bile Duct Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT00047125 2018-07-09

Radiation Therapy in Treating Patients With Metastases to the Lymph Nodes in the Neck From an Unknown Primary Tumor

600 enrolled

Neoplasms, Unknown Primary

NCT00004005 2017-04-26

Irinotecan Followed By Fluorouracil and Leucovorin in Treating Patients With Stage III or Stage IV Colorectal Carcinoma (Cancer), Other Refractory Carcinoma, or Metastatic Adenoma (Cancer) of Unknown Primary Origin

12 enrolled

Colonic Neoplasms, Neoplasms, Unknown Primary, Rectal Neoplasms, Colorectal Neoplasms

NCT00066781 2017-04-04

Gemcitabine and Irinotecan in Treating Patients With Cancer of Unknown Primary

31 enrolled 8 charts

Neoplasms, Unknown Primary

NCT00936702 2017-03-21

Carboplatin, Paclitaxel, and Everolimus in Treating Patients With Previously Untreated Cancer of Unknown Primary

46 enrolled 13 charts

Neoplasms, Unknown Primary

NCT00003657 2017-01-20

High-dose ICE With Amifostine

CNSGenitourinaryGynecologicHead & NeckSarcomaThoracic

24 enrolled

AIDS-related Kaposi sarcoma, Testicular Germ Cell Tumor, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Ovarian Epithelial, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Chondrosarcoma, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Neoplasms, Unknown Primary, Ovarian Neoplasms, Sarcoma, Sarcoma, Kaposi, Osteosarcoma, Testicular Neoplasms, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Esthesioneuroblastoma, Olfactory, Small Cell Lung Carcinoma

NCT00003582 2016-12-15

Radiation Therapy, Combination Chemotherapy, and Amifostine in Treating Patients With Head and Neck Cancer

Phase 1/2 Completed

36 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Unknown Primary

NCT00201734 2016-09-23

Capecitabine, Carboplatin and Weekly Paclitaxel for Patients With Solid Tumors and Adenocarcinoma of Unknown Primary

Phase 1/2 Terminated

57 enrolled 11 charts

Adenocarcinoma, Neoplasms, Neoplasms, Unknown Primary

NCT02789371 2016-06-07

Comparing of Modified Wet Suction Technique and Dry Suction Technique for EUS-FNA of Solid Occupying Lesions

Phase NA Unknown

296 enrolled

Lymphadenopathy, Infections, Inflammation, Lymphatic Metastasis, Neoplasm Metastasis, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Sarcoidosis

NCT02590055 2015-10-28

Phase 2 Study of Gemcitabine and Docetaxel Combination Chemotherapy in Patients With Carcinoma of Unknown Primary

Phase 2 Unknown

29 enrolled

Neoplasms, Unknown Primary

NCT00873119 2015-07-28

Belinostat, Carboplatin and Paclitaxel (BelCaP) Compared to Carboplatin and Paclitaxel in Patients With Cancer of Unknown Primary

89 enrolled 12 charts

Neoplasms, Unknown Primary

NCT00119314 2015-05-27

Gemcitabine, Docetaxel, and Capecitabine in Treating Patients With Cancer of Unknown Primary Origin

Phase 2 Withdrawn

Neoplasms, Unknown Primary

NCT00458315 2015-05-08

Cisplatin/Paclitaxel/Gemcitabine +/- Avastin in Patients With Unknown Primary Tumor

Phase 2 Withdrawn