Clinical Trials Browser

Phase 1 × Has results × Neoplasms × Clear all

NCT07450833 2026-03-27

BOOST

Phase 1 Completed

48 enrolled 38 charts

COVID-19, Neoplasms, Korsakoff Syndrome

NCT03568058 2026-03-24

Personalized Immunotherapy in Adults With Advanced Cancers Immunotherapy in Adults With Advanced Cancers

Phase 1 Completed

25 enrolled 12 charts

Neoplasms

NCT02952248 2026-01-27

A Trial to Find and Investigate a Safe Dose of a New Substance (BI 754091) for Patients With Solid Tumours

Phase 1 Completed

110 enrolled 22 charts

Neoplasms

NCT03156114 2026-01-26

This Study Tests the New Medicine BI 754111 Alone or in Combination With Another New Substance BI 754091 in Patients With Advanced Cancer. The Study Tests Different Doses to Find the Best Dose for Continuous Treatment.

Phase 1 Completed

172 enrolled 33 charts

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT04544995 2026-01-21

Dose Escalation and Cohort Expansion Study of Niraparib and Dostarlimab in Paediatric Participants With Solid Tumors (SCOOP)

Phase 1 Terminated

47 enrolled 43 charts

Neoplasms, Neuroblastoma, Osteosarcoma

NCT03843359 2026-01-08

A First Time in Human (FTIH) Study of GSK3745417 Administered to Participants With Advanced Solid Tumors

Phase 1 Active not recruiting

97 enrolled 45 charts

Bites and Stings, Neoplasms

NCT05678998 2026-01-06

WTX-330 in Patients With Advanced or Metastatic Solid Tumors or Non-Hodgkin Lymphoma

Phase 1 Completed

25 enrolled 31 charts

Lymphoma, Non-Hodgkin, Neoplasms

NCT01695005 2025-12-26

A Study of LY3039478 in Participants With Advanced Cancer

Phase 1 Completed

247 enrolled 53 charts

Lymphoma, Neoplasm Metastasis, Neoplasms

NCT02275910 2025-12-16

Phase 1 Study of E7090 in Subjects With Solid Tumor

Phase 1 Completed

40 enrolled 30 charts

Neoplasms

NCT02860676 2025-12-15

Extension Study of UC-961 (Cirmtuzumab) for Patients With Chronic Lymphocytic Leukemia Treated Previously With UC-961

Phase 1 Completed

3 enrolled 8 charts

LymphoidOther hematologic neoplasm

Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell

NCT03307785 2025-11-25

Study of Niraparib, TSR-022, Bevacizumab, and Platinum-Based Doublet Chemotherapy in Combination With TSR-042

Phase 1 Completed

60 enrolled 91 charts

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Neoplasms

NCT02197234 2025-11-20

Study to Assess the Effect of AZD9291 on the Blood Levels of Simvastatin in Patients With EGFRm+ NSCLC

Phase 1 Completed

52 enrolled 14 charts

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT02157883 2025-11-19

Study to Assess the Effect of Itraconazole (a CYP3A4 Inhibitor) on the Pharmacokinetics of AZD9291, in Patients With EGFR Positive Non-small Cell Lung Cancer. Patients Will be Chosen From Those Who Have Already Been Prescribed an EGFR TKI Medicine (Such as Iressa or Tarceva)

Phase 1 Completed

39 enrolled 18 charts

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT05980416 2025-11-14

Study of EO-3021 in Adult Patients With Solid Tumors Likely to Express CLDN18.2

Phase 1 Terminated

88 enrolled 18 charts

Gastrointestinal

Adenocarcinoma, Digestive System Neoplasms, Gastrointestinal Neoplasms, Neoplasms, Neoplasms by Site, Stomach Neoplasms

NCT03468426 2025-11-10

A Study to Test Different Doses of BI 836880 Combined With Ezabenlimab in Patients With Advanced Non-small Cell Lung Cancer Followed by Other Types of Advanced Solid Tumours

Phase 1 Completed

252 enrolled 47 charts

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT04543188 2025-10-23

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

Phase 1 Terminated

65 enrolled 52 charts

CNSDermatologicThoracic

Brain Diseases, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasms, Central Nervous System Neoplasms

NCT02964013 2025-10-14

KEYVIBE-001

Phase 1 Completed

474 enrolled 39 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Neoplasms

NCT03972150 2025-10-06

A Study to Find the Best Dose of BI 836880 Alone and in Combination With BI 754091 in Japanese Patients With Different Types of Advanced Cancer

Phase 1 Completed

21 enrolled 21 charts

Neoplasms

NCT02674152 2025-10-01

Dose Finding Study of BI 836880 in Patients With Solid Tumors

Phase 1 Completed

29 enrolled 17 charts

Neoplasms

NCT02689505 2025-10-01

Weekly BI 836880 in Patients With Advanced Solid Tumors

Phase 1 Completed

24 enrolled 13 charts

Neoplasms

NCT05237206 2025-09-18

Study of SUPLEXA in Patients With Metastatic Solid Tumours and Haematologic Malignancies

Phase 1 Completed

46 enrolled 10 charts

Neoplasms

NCT04147234 2025-08-19

A Study to Find the Best Dose of BI 1387446 Alone or in Combination With Ezabenlimab (BI 754091) in Patients With Different Types of Advanced or Metastatic Cancer (Solid Tumors)

Phase 1 Completed

42 enrolled 14 charts

Neoplasms

NCT05708924 2025-08-14

MT2021-27 FT538 Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

Phase 1 Terminated

1 enrolled 5 charts

Fallopian Tube Neoplasms, Neoplasms, Ovarian Neoplasms

NCT00716417 2025-08-05

Study to Determine the Maximum Tolerated Dose of BIBW 2992 (Afatinib) When Combined With Cisplatin/Paclitaxel or Cisplatin/5-FU in Patients With Advanced Solid Tumours

Phase 1 Completed

47 enrolled 18 charts

Neoplasms

NCT03307629 2025-07-29

Safety and Tolerability of NOX66 in Combination With Palliative Radiotherapy in Patients With Late-Stage Prostate Cancer

Phase 1 Completed

25 enrolled 24 charts

Neoplasms

NCT04306900 2025-07-29

TTX-030 in Combination With Immunotherapy and/or Chemotherapy in Subjects With Advanced Cancers

Phase 1 Completed

185 enrolled 28 charts

GastrointestinalGenitourinaryThoracic

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT01403974 2025-07-25

Phase I Trial of BI 836845 for Various Solid Cancer

Phase 1 Completed

61 enrolled 33 charts

Neoplasms

NCT02123823 2025-07-15

BI 836845 in Estrogen Receptor Positive Metastatic Breast Cancer

Phase 1 Completed

164 enrolled 21 charts

Neoplasms

NCT04477759 2025-07-15

DEHART

Phase 1 Completed

18 enrolled 12 charts

Head and Neck Neoplasms, Neoplasms

NCT01317420 2025-07-11

Trial to Determine MTD of BI 836845 Administered Intravenously Once Every Three Weeks in Patients With Advanced Solid Tumours and Later a Weekly Dosing Schedule in Selected Tumour Types

Phase 1 Completed

64 enrolled 27 charts

Neoplasms

NCT03128047 2025-07-08

HUMC 1612: Optune NovoTTF-200A System

Phase 1 Completed

7 enrolled 12 charts

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms

NCT03884556 2025-07-02

TTX-030 Single Agent and in Combination With Immunotherapy or Chemotherapy for Patients With Advanced Cancers

Phase 1 Completed

56 enrolled 19 charts

GastrointestinalGenitourinaryLymphoidThoracic

Urinary Bladder Neoplasms, Lung Neoplasms, Lymphoma, Neoplasms, Pancreatic Neoplasms

NCT03099174 2025-06-24

This Study in Patients With Different Types of Cancer (Solid Tumours) Aims to Find a Safe Dose of Xentuzumab in Combination With Abemaciclib With or Without Hormonal Therapies. The Study Also Tests How Effective These Medicines Are in Patients With Lung and Breast Cancer

Phase 1 Completed

133 enrolled 26 charts

Breast Neoplasms, Neoplasms

NCT02145741 2025-06-19

Weekly Intravenous Administrations of BI 836845 in Japanese Patients With Advanced Solid Tumours

Phase 1 Completed

21 enrolled 9 charts

Neoplasms

NCT02720068 2025-05-30

MK-4280-001

Phase 1 Completed

481 enrolled 36 charts

Parkinson Disease 4, Autosomal Dominant Lewy Body, Neoplasms

NCT02663297 2025-05-15

Administration of T Lymphocytes for Prevention of Relapse of Lymphomas

Phase 1 Active not recruiting

18 enrolled 10 charts

Hodgkin Disease, Immune System Diseases, Immunoproliferative Disorders, Lymphatic Diseases, Lymphoma, Lymphoma, Non-Hodgkin, Lymphoproliferative Disorders, Neoplasms, Neoplasms by Histologic Type

NCT02875223 2025-04-20

A Safety and Efficacy Study of CC-90011 in Participants With Relapsed and/or Refractory Solid Tumors and Non-Hodgkin's Lymphomas

Phase 1 Terminated

75 enrolled 35 charts

Lymphoma, Non-Hodgkin, Neoplasms

NCT03724890 2025-04-10

Study of Avelumab-M3814 Combinations

Phase 1 Completed

57 enrolled 56 charts

Neoplasms

NCT02783300 2025-03-10

Meteor 1

Phase 1 Completed

297 enrolled 76 charts

DermatologicGenitourinaryHead & NeckLymphoidThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Adenoid Cystic, Lymphoma, Non-Hodgkin, Melanoma, Neoplasms, Urologic Neoplasms

NCT02834390 2025-03-05

Study of Quizartinib in Japanese Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)

Phase 1 Completed

7 enrolled 16 charts

Other hematologic neoplasm

Neoplasms, Leukemia, Myeloid, Acute

NCT01214616 2025-02-07

BIBW 2992 (Afatinib) and Vinorelbine in Japanese Patients With Advanced Solid Tumours

Phase 1 Completed

17 enrolled 15 charts

Neoplasms

NCT03447470 2025-01-29

Study to Evaluate the Safety and Tolerability of RXC004 in Advanced Malignancies

Phase 1 Completed

46 enrolled 29 charts

Gastrointestinal

Biliary Tract Neoplasms, Neoplasms, Thymus Neoplasms

NCT03948763 2025-01-28

V941-001

Phase 1 Terminated

70 enrolled 18 charts

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms

NCT01121588 2025-01-23

Studying An Investigational Drug Crizotinib (PF-02341066) In Non Non-Small Cell Lung Cancer Tumors That Are Positive For Anaplastic Lymphoma Kinase (ALK)

Phase 1 Terminated

44 enrolled 22 charts 2 FDA

Lymphoma, Neoplasms, Neuroblastoma

NCT01946789 2025-01-22

A Phase 1 Study of the Clinical and Immunologic Effects of ALT-803 in Patients With Advanced Solid Tumors

Phase 1 Completed

26 enrolled 22 charts

Melanoma, Neoplasm Metastasis, Neoplasms

NCT02751528 2025-01-13

QUILT-3.013: Study of Ad5 [E1-, E2b-]-HER2/Neu Vaccine (ETBX-021) in Subjects With Unresectable Locally Advanced or Metastatic HER2-Expressing Breast Cancer

Phase 1 Terminated

3 enrolled 10 charts

Breast Neoplasms, Neoplasm Metastasis, Neoplasms, Breast Neoplasms, Male

NCT02723955 2024-12-27

Dose Escalation and Expansion Study of GSK3359609 in Participants With Selected Advanced Solid Tumors (INDUCE-1)

Phase 1 Completed

829 enrolled 100 charts

Neoplasms

NCT04526509 2024-11-26

Master Protocol to Assess Safety and Dose of First Time in Human Next Generation Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Advanced Solid Tumors

Phase 1 Terminated

12 enrolled 12 charts

Neoplasms, Liposarcoma, Myxoid

NCT02972034 2024-11-21

MK-8353-013

Phase 1 Terminated

111 enrolled 30 charts

Gastrointestinal

Neoplasms, Colorectal Neoplasms

NCT03027128 2024-11-20

QUILT-3.028: Study of haNK™ for Infusion in Subjects With Metastatic or Locally Advanced Solid Tumors

Phase 1 Completed

6 enrolled 10 charts

Neoplasm Metastasis, Neoplasms