Clinical Trials Browser

Phase 2 × Neoplasms × Irinotecan × Clear all

NCT03678883 2026-04-03

9-ING-41 in Patients With Advanced Cancers

Phase 2 Active not recruiting

BreastCNSGastrointestinalGenitourinaryLymphoidOther hematologic neoplasmSarcomaThoracic

Bone Neoplasms, Breast Neoplasms, Glioma, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Neoplasms, Hereditary Sensory and Autonomic Neuropathies, Pancreatic Neoplasms, Sarcoma, Colorectal Neoplasms, Leukemia-Lymphoma, Adult T-Cell

NCT05999994 2026-03-27

CAMPFIRE

Phase 2 Recruiting

Neoplasms

NCT01042379 2026-03-13

I-SPY

Phase 2 Recruiting

Pathologic Complete Response, Breast Neoplasms, Hemangiosarcoma, Neoplasms, Triple Negative Breast Neoplasms

NCT06107413 2025-12-12

Study to Assess Adverse Events and Change in Disease Activity in Previously Treated Adult Participants Receiving Intravenous (IV) ABBV-400 With Unresectable Metastatic Colorectal Cancer in Combination With IV Fluorouracil, Folinic Acid, and Bevacizumab

Phase 2 Active not recruiting

Neoplasms

NCT06846346 2025-11-28

GRACIE

Phase 2 Recruiting

Gastrointestinal

Adenocarcinoma Of Esophagus, Adenocarcinoma, Neoplasm Metastasis, Neoplasms

NCT05678257 2025-09-12

A Study of NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer

Phase 2 Terminated

180 enrolled 16 charts

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT03709680 2025-01-14

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Phase 2 Active not recruiting

Diffuse Intrinsic Pontine Glioma, Bone Neoplasms, Medulloblastoma, Neoplasms, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Rhabdoid Tumor

NCT02842580 2024-07-10

HIGH-LIGHT

Phase 2 Terminated

21 enrolled 12 charts

Gastrointestinal

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT01726582 2023-08-14

Pancreas Cancer: Molecular Profiling as a Guide to Therapy Before and After Surgery ("Personalized Medicine")

Phase 2 Completed

229 enrolled 14 charts

Gastrointestinal

Adenocarcinoma, Neoplasms, Pancreatic Neoplasms

NCT02178709 2022-04-19

A Phase II Study of Neoadjuvant FOLFIRINOX

Phase 2 Completed

48 enrolled 16 charts

Neoplasms

NCT01660711 2021-11-08

A Pilot Study of Pre- and Post-surgery Chemotherapy With mFOLFIRINOX in Localized, Resectable Pancreatic Adenocarcinoma

Phase 2 Completed

22 enrolled 8 charts

Adenocarcinoma, Neoplasms

NCT03368859 2021-02-09

A Study of ABT-165 Plus FOLFIRI vs Bevacizumab Plus FOLFIRI in Subjects With Metastatic Colorectal Cancer Previously Treated With Fluoropyrimidine, Oxaliplatin and Bevacizumab

Phase 2 Terminated

70 enrolled 12 charts

Gastrointestinal

Intestinal Neoplasms, Neoplasms, Colorectal Neoplasms

NCT01858649 2020-10-22

BEV-ONCO2012

Phase 2 Completed

Gastrointestinal

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT01479465 2019-04-17

Efficacy and Safety of Simtuzumab (SIM) With FOLFIRI as Second Line Treatment in Colorectal Adenocarcinoma

Phase 2 Terminated

266 enrolled 15 charts

Gastrointestinal

Neoplasms, Colorectal Neoplasms

NCT00418938 2018-10-17

SPIRITT - Second-Line Panitumumab Irinotecan Treatment Trial

Phase 2 Completed

266 enrolled 17 charts

Gastrointestinal

Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT02241551 2018-07-26

Phase II Neoadjuvant Chemotheraphy (Gemcitabine and Nab-Paclitaxel vs. mFOLFIRINOX) and Sterotatic Body Radiation Therapy for Borderline Resectable Pancreatic Cancer

Phase 2 Terminated

2 enrolled 7 charts

Neoplasms

NCT00845039 2018-07-02

FC-4

Phase 2 Terminated

4 enrolled 9 charts

Gastrointestinal

Colonic Neoplasms, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01888978 2018-04-09

Molecularly Tailored Therapy for Pancreas Cancer

Phase 2 Completed

Gastrointestinal

Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms

NCT00682786 2017-10-06

Genotype-directed Neoadjuvant Chemoradiation for Rectal Carcinoma

Phase 2 Completed

135 enrolled 17 charts

Gastrointestinal

Carcinoma, Neoplasms, Rectal Neoplasms

NCT02316496 2017-08-01

REGAIN

Phase 2 Terminated

Neoplasm Metastasis, Neoplasms

NCT00400114 2017-05-08

Sutent Following Chemotherapy, Radiation and Surgery For Resectable Esophageal Cancer

Phase 2 Completed

Gastrointestinal

Esophageal Neoplasms, Neoplasms

NCT00416767 2016-05-30

Combination Chemotherapy as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Neuroendocrine Tumors of the Duodenum or Pancreas That Cannot Be Removed By Surgery

Phase 2 Completed

Vipoma, Glucagonoma, Insulinoma, Adenoma, Islet Cell, Neoplasms, Somatostatinoma, Gastrinoma, Carcinoma, Islet Cell

NCT00642746 2014-09-26

Erlotinib and Chemotherapy for 2nd Line Treatment (Tx) of Metastatic Colorectal Cancer (mCRC)

Phase 2 Terminated

16 enrolled 9 charts

Gastrointestinal

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT01322152 2013-06-11

Study of Irinotecan Plus Capecitabine to Treat Advanced Colorectal Cancer

Phase 2 Completed

Gastrointestinal

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT00614965 2011-05-23

Irinotecan Plus Cisplatin vs Pemetrexed Plus Cisplatin as 2nd Line in NSCLC Stage IIIB/IV

Phase 2 Completed

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT00057473 2011-04-14

A Phase II Study of Carboplatin Plus Irinotecan Versus Irinotecan in Children With Refractory Solid Tumors

Phase 2 Completed

Neoplasms

NCT00276003 2010-01-07

INST Phase II Trial of Gemcitabine and Irinotecan in Patients With Relapsed or Refractory Lymphoma.

Phase 2 Completed

Lymphoma, Non-Hodgkin, Neoplasms

NCT00135135 2008-06-03

Therapy for Children With Neuroblastoma

Phase 2 Completed

Neoplasms, Neuroblastoma