Clinical Trials Browser

Neoplasms × Sirolimus × Clear all

NCT00092222 2026-05-22

Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity

Multi-centric Castleman's Disease, Macular dystrophy, corneal type 1, Lymphadenopathy, Lymphoproliferative Disorders, Neoplasms, HIV Infections

NCT01552434 2026-05-15

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Phase 1 Terminated

154 enrolled

BreastCNSGenitourinaryHead & NeckLymphoidMyeloidSarcoma

Breast Neoplasms, Carcinoma, Transitional Cell, Endocrine Gland Neoplasms, Castleman Disease, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms, Pharyngeal Neoplasms, Recurrence, Sarcoma, Soft Tissue Neoplasms, Thyroid Neoplasms, Urologic Neoplasms, Neurofibromatosis 2, Lymphangioleiomyomatosis, Neoplasms, Mesothelial, Erdheim-Chester Disease

NCT02574728 2026-03-02

AflacST1502

Phase 2 Active not recruiting

46 enrolled

CNSMyeloidSarcoma

Brain Neoplasms, Carcinoma, Ependymoma, Histiocytosis, Langerhans-Cell, Medulloblastoma, Neoplasms, Neoplasms, Germ Cell and Embryonal, Neuroblastoma, Pinealoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Rhabdoid Tumor

NCT03203525 2026-02-25

Combination Chemotherapy and Bevacizumab With the NovoTTF-100L(P) System in Treating Participants With Advanced, Recurrent, or Refractory Hepatic Metastatic Cancer

Phase 1 Active not recruiting

38 enrolled

Tumor-Agnostic

Neoplasms

NCT03512756 2024-11-06

A Randomized Phase 2/3 Multi-Center Study of SM-88 in Participants With Metastatic Pancreatic Cancer

Phase 2/3 Terminated

130 enrolled 13 charts

Gastrointestinal

Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms

NCT04393454 2024-07-25

Study to Evaluate the Efficacy and Safety of Sirolimus in Subjects With Metastatic, Mismatch Repair Deficient Solid Tumors After Immunotherapy

Phase 2 Terminated

6 enrolled 12 charts

Tumor-Agnostic

Neoplasm Metastasis, Neoplasms

NCT04987463 2024-02-08

ViRap

Phase 2/3 Unknown

60 enrolled

Epilepsy, Neoplasms, Tuberous Sclerosis

NCT00126672 2022-04-25

RAPAMYCIN FOR KIDNEY ANGIOMYOLIPOMAS

Phase 2 Completed

36 enrolled 8 charts

Neoplasms, Tuberous Sclerosis, Angiomyolipoma

NCT01266057 2021-03-04

Sirolimus or Vorinostat and Hydroxychloroquine in Advanced Cancer

Phase 1 Completed

143 enrolled

Tumor-Agnostic

Neoplasms

NCT01162551 2019-08-06

Trial of Sirolimus and Methotrexate in Relapsed/Refractory Lymphoblastic Leukemia and Lymphoma

Phase 2 Completed

5 enrolled 7 charts

LymphoidOther hematologic neoplasm

Leukemia, Lymphoma, Lymphoma, Non-Hodgkin, Neoplasms

NCT00433485 2016-09-23

Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants

Phase 1 Completed

16 enrolled

Dermatologic

Basal Cell Nevus Syndrome, Carcinoma, Basal Cell, Neoplasms

NCT00678769 2015-11-04

Cixutumumab and Temsirolimus in Treating Patients With Locally Advanced or Metastatic Cancer

Phase 1 Completed

72 enrolled

Tumor-Agnostic

Neoplasms

NCT01827618 2015-07-02

Neoadjuvant Rapamycin in Patients Undergoing Radical Cystectomy

Phase EARLY_PHASE1 Completed

29 enrolled

Tumor-Agnostic

Neoplasms

NCT00290472 2014-05-23

CCI-779 in Treating Patients With Recurrent or Refractory B-Cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia

Phase 2 Completed

89 enrolled 9 charts

LymphoidOther hematologic neoplasm

Burkitt Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00375245 2014-01-17

Rapamycin With Grapefruit Juice for Advanced Malignancies

Phase 1 Completed

41 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther solid neoplasmThoracic

Urinary Bladder Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma, Melanoma, Mesothelioma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms

NCT00402415 2013-12-18