Clinical Trials

Phase 1 Active not recruiting

Neoplasms

NCT01552434 2025-10-14

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

155 enrolled

BreastCNSGenitourinaryHead & NeckLymphoidMyeloidSarcoma

Breast Neoplasms, Carcinoma, Transitional Cell, Endocrine Gland Neoplasms, Castleman Disease, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms, Pharyngeal Neoplasms, Recurrence, Sarcoma, Soft Tissue Neoplasms, Thyroid Neoplasms, Urologic Neoplasms, Neurofibromatosis 2, Lymphangioleiomyomatosis, Neoplasms, Mesothelial, Erdheim-Chester Disease

NCT03512756 2024-11-06

A Randomized Phase 2/3 Multi-Center Study of SM-88 in Participants With Metastatic Pancreatic Cancer

Phase 2/3 Terminated

130 enrolled 13 charts

Gastrointestinal

Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms

NCT04393454 2024-07-25

Study to Evaluate the Efficacy and Safety of Sirolimus in Subjects With Metastatic, Mismatch Repair Deficient Solid Tumors After Immunotherapy

Phase 2 Terminated

6 enrolled 12 charts

Neoplasm Metastasis, Neoplasms

NCT04987463 2024-02-08

ViRap

Phase 2/3 Unknown

60 enrolled

Epilepsy, Neoplasms, Tuberous Sclerosis

NCT00126672 2022-04-25

RAPAMYCIN FOR KIDNEY ANGIOMYOLIPOMAS

36 enrolled 8 charts

Neoplasms, Tuberous Sclerosis, Angiomyolipoma

NCT01266057 2021-03-04

Sirolimus or Vorinostat and Hydroxychloroquine in Advanced Cancer

143 enrolled

Neoplasms

NCT01162551 2019-08-06

Trial of Sirolimus and Methotrexate in Relapsed/Refractory Lymphoblastic Leukemia and Lymphoma

5 enrolled 7 charts

Leukemia, Lymphoma, Lymphoma, Non-Hodgkin, Neoplasms

NCT00433485 2016-09-23

Topical Sirolimus in Patients With Basal Cell Nevus Syndrome and in Healthy Participants

16 enrolled

Dermatologic

Basal Cell Nevus Syndrome, Carcinoma, Basal Cell, Neoplasms

NCT00678769 2015-11-04

Cixutumumab and Temsirolimus in Treating Patients With Locally Advanced or Metastatic Cancer

72 enrolled

Phase EARLY_PHASE1 Completed

Neoplasms

NCT01827618 2015-07-02

Neoadjuvant Rapamycin in Patients Undergoing Radical Cystectomy

29 enrolled

Neoplasms

NCT00290472 2014-05-23

CCI-779 in Treating Patients With Recurrent or Refractory B-Cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia

89 enrolled 9 charts

Burkitt Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, B-Cell, Marginal Zone, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00375245 2014-01-17

Rapamycin With Grapefruit Juice for Advanced Malignancies

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther solid neoplasmThoracic

41 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma, Melanoma, Mesothelioma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms

NCT00402415 2013-12-18

Study of Combination of Sirolimus and Sutent in Patients With Advanced Solid Tumors Non-Curable With Standard Therapy

Phase 1 Terminated

18 enrolled

Neoplasm Metastasis, Neoplasms

NCT00957320 2013-12-03

Study of Sirolimus With PEG-Asparaginase in Acute Lymphoblastic Leukemia (ALL)

Phase 1 Withdrawn

Leukemia, Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00795886 2013-07-31

Rapamycin for Immunosuppression and B Cell Modulation Post Stem Cell Transplant for Acute Lymphoblastic Leukemia (ALL)

63 enrolled 9 charts