Clinical Trials

70 enrolled

CNS

Glioblastoma, Neoplasms

NCT06870487 2026-05-08

A Study to Learn About the Study Medicine Called PF-08046032 in People With Advanced Cancers

DermatologicHead & NeckLymphoidOther hematologic neoplasmThoracic

6 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Hodgkin Disease, Lung Neoplasms, Lymphoma, Non-Hodgkin, Melanoma, Neoplasm Metastasis, Neoplasms, Skin Neoplasms, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Peripheral, Hematologic Neoplasms

NCT06046066 2026-05-07

A Phase 1 Study of NM6603 in Advanced Solid Tumors

17 enrolled

Neoplasms

NCT01604889 2026-04-21

A Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With Epacadostat or Placebo in Subjects With Unresectable or Metastatic Melanoma

50 enrolled

Melanoma, Neoplasms, Skin Neoplasms

NCT07479381 2026-04-09

CLEAR

Terminated

14 enrolled

Disease, Neoplasms, Colorectal Neoplasms

NCT04931823 2026-04-03

Dose Escalation and Dose Expansion Study of CPO-100 in Patients With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

34 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Stomach Neoplasms

NCT05933070 2026-03-30

LAUREL

MyeloidOther hematologic neoplasm

2 enrolled

Myelodysplastic Syndromes, Neoplasms, Leukemia, Myeloid, Acute

NCT06188208 2026-03-30

A First-in-Human (FIH) Study to Evaluate the Safety and Tolerability of VVD-130850 in Participants With Advanced Solid and Hematologic Tumors

132 enrolled

Neoplasms

NCT04222972 2026-03-05

AcceleRET-Lung

Phase 3 Terminated

223 enrolled 18 charts

Head & NeckThoracic

Adenocarcinoma, Bronchial Diseases, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Nerve Tissue, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms

NCT06546553 2026-02-23

A Study to Learn About How Different Amounts of the Study Medicine PF-07826390 Act in the Body of People With Cancer When Taken Alone or With Other Anti-cancer Medicines.

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

10 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Kidney Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Rectal Diseases, Colorectal Neoplasms

NCT04157517 2026-01-29

A Study of Modakafusp Alfa (TAK-573) Given by Itself and Together With Pembrolizumab in Adults With Advanced or Metastatic Solid Tumors

45 enrolled 44 charts

Melanoma, Neoplasms

NCT06457997 2026-01-29

A Study of PHN-010 in Patients With Advanced Solid Tumors

GastrointestinalGynecologicThoracic

26 enrolled

Carcinoma, Uterine Cervical Neoplasms, Colonic Neoplasms, Lung Neoplasms, Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms

NCT04544995 2026-01-21

Dose Escalation and Cohort Expansion Study of Niraparib and Dostarlimab in Paediatric Participants With Solid Tumors (SCOOP)

47 enrolled 43 charts

CNSSarcoma

Neoplasms, Neuroblastoma, Osteosarcoma

NCT05450562 2026-01-14

Dose Escalation and Expansion Study of SAR444200-based Regimen in Adult Participants With Advanced Solid Tumors

33 enrolled

Neoplasms

NCT04260802 2026-01-12

A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

73 enrolled

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms, Carcinoma, Merkel Cell, Triple Negative Breast Neoplasms

NCT05209295 2026-01-12

A Study to Evaluate CC-486/Onureg in Participants With Moderate or Severe Hepatic Impairment Compared With Normal Hepatic Function in Participants With Myeloid Malignancies

2 enrolled

Neoplasms, Hepatic Insufficiency

NCT03993379 2025-12-26

PROCLAIM: CX-072-002: Study of PD-L1 Probody Therapeutic CX-072 in Combination With Other Anticancer Therapy in Adults With Solid Tumors

3 enrolled 7 charts

Diabetes Mellitus, Insulin-Dependent, 12, Melanoma, Neoplasms, Recurrence

NCT04009681 2025-12-15

HAMMER

175 enrolled

Neoplasm Metastasis, Neoplasms

NCT01023412 2025-12-10

IPOD-3

Phase NA Terminated

107 enrolled

Gastrointestinal Neoplasms, Neoplasms

NCT04106492 2025-11-14

Phase 1/2a Study of SQ3370 in Patients With Advanced Solid Tumors

GynecologicHead & NeckSarcomaThoracic

53 enrolled 23 charts

Head and Neck Neoplasms, Lung Neoplasms, Neoplasms, Ovarian Neoplasms, Sarcoma, Uterine Neoplasms

NCT05980416 2025-11-14

Study of EO-3021 in Adult Patients With Solid Tumors Likely to Express CLDN18.2

88 enrolled 18 charts

Adenocarcinoma, Digestive System Neoplasms, Gastrointestinal Neoplasms, Neoplasms, Neoplasms by Site, Stomach Neoplasms

NCT05935748 2025-11-12

Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carcinoma (ccRcc)

18 enrolled

Genitourinary

Adenocarcinoma, Carcinoma, Carcinoma, Renal Cell, Kidney Diseases, Kidney Neoplasms, Neoplasms, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Urogenital Neoplasms, Urologic Diseases, Urologic Neoplasms

NCT05513703 2025-10-24

A Study to Assess Disease Activity of Intravenously (IV) Infused Telisotuzumab Vedotin in Adult Participants With Advanced/Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

9 enrolled 13 charts

Thoracic

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT04543188 2025-10-23

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

65 enrolled 52 charts

CNSDermatologicThoracic

Brain Diseases, Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasms, Central Nervous System Neoplasms

NCT05694013 2025-10-22

ORIGAMA

Phase 2/3 Terminated

49 enrolled 14 charts

Neoplasms

NCT06523803 2025-10-21

A Study of ZW171 in Participants With Advanced or Metastatic Mesothelin-expressing Cancers

32 enrolled

Neoplasms

NCT05646797 2025-10-20

A Study of ASP2074 in Adults With Solid Tumors

23 enrolled

Neoplasm Metastasis, Neoplasms

NCT04363801 2025-10-09

DisTinGuish

247 enrolled 38 charts

Adenocarcinoma, Neoplasms, Stomach Neoplasms

NCT03287908 2025-10-08

A Study to Assess AMG 701 Montherapy, or in Combination With Pomalidomide, With or Without, Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma

Other hematologic neoplasm

174 enrolled

Plasma cell

Multiple Myeloma, Neoplasms

NCT04161885 2025-10-06

VIALE-T

Phase 3 Terminated

465 enrolled

Neoplasms, Leukemia, Myeloid, Acute

NCT05221320 2025-09-25

Trial of Ulixertinib in Combination With Hydroxychloroquine in Patients With Advanced Gastrointestinal (GI) Malignancies

47 enrolled 18 charts

Gastrointestinal Neoplasms, Neoplasms

NCT06285097 2025-09-17

A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumors

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

9 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Melanoma, Neoplasms, Ovarian Neoplasms, Colorectal Neoplasms

NCT05013554 2025-09-15

Dose Escalation and Expansion Study of SAR443216 in Participants With Relapsed/Refractory HER2 Expressing Solid Tumors

BreastGastrointestinalThoracic

44 enrolled

Breast Neoplasms, Lung Neoplasms, Neoplasms, Stomach Neoplasms

NCT06175221 2025-09-15

Autologous TLPO Vaccine Basket

63 enrolled

Neoplasm Metastasis, Neoplasms

NCT04989387 2025-09-02

Study of INCA 0186 in Subjects With Advanced Solid Tumors

GastrointestinalHead & Neck

57 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hepatocellular, Neoplasms, Colorectal Neoplasms

NCT04458259 2025-08-28

Study of PF-07265807 in Participants With Metastatic Solid Tumors.

DermatologicGastrointestinalGenitourinaryGynecologicThoracic

88 enrolled

Parkinson Disease 4, Autosomal Dominant Lewy Body, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Small Cell Lung Carcinoma

NCT06877533 2025-08-12

A First-in-Human Open-label, Phase I/Ib Dose Escalation and Expansion Cohort Study of EOS006215 as Monotherapy and in Combination With Pembrolizumab or Other Anticancer Treatments in Participants With Advanced Solid Tumors

3 enrolled

Neoplasm Metastasis, Neoplasms

NCT04717375 2025-08-07

Study of SAR444881 Administered Alone and in Combination With Other Therapeutics in Participants With Advanced Solid Tumors

125 enrolled

Neoplasms

NCT06038760 2025-07-30

PEAR-GLIO

Terminated

12 enrolled

CNS

Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Neoplasms, Oligodendroglioma

NCT04239092 2025-07-17

9-ING-41 in Pediatric Patients With Refractory Malignancies.

40 enrolled

CNS

Diffuse Intrinsic Pontine Glioma, Meningioma, Neoplasms, Neuroblastoma

NCT05153330 2025-07-03

Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL

LymphoidOther hematologic neoplasmPlasma cell

55 enrolled

Lymphoma, Lymphoma, Non-Hodgkin, Multiple Myeloma, Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute, Lymphoma, Large B-Cell, Diffuse, Disease Progression, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03013491 2025-06-17

PROCLAIM-CX-072: A Trial to Find Safe and Active Doses of an Investigational Drug CX-072 for Patients With Solid Tumors or Lymphomas

196 enrolled 28 charts

Lymphoid

Diabetes Mellitus, Insulin-Dependent, 12, Lymphoma, Neoplasms

NCT04830124 2025-06-10

ARTISTRY-6

173 enrolled

Melanoma, Neoplasms

NCT06790303 2025-06-04

Platform Trial of Novel Regimens Versus Standard of Care (SoC) in Participants With Non-small Cell Lung Cancer (NSCLC) - Sub-study 2

8 enrolled 11 charts

Neoplasms

NCT04442126 2025-05-23

A Study of NM21-1480 in Adult Patients With Advanced Solid Tumors