Clinical Trials

EndocrineGastrointestinalHead & NeckNETSarcomaThoracic

500 enrolled 2 FDA

Adenocarcinoma, Bronchial Neoplasms, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Diseases, Colonic Neoplasms, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Sarcoma, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Neuroectodermal Tumors, Carcinoma, Neuroendocrine, Neuroendocrine Tumors

NCT03899155 2026-05-27

Pan Tumor Rollover Study

1,500 enrolled

Neoplasms

NCT04928846 2026-05-27

A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

698 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Neoplasms

NCT04958239 2026-05-27

A Study to Test BI 765179 Alone and in Combination With Ezabenlimab in Patients With Advanced Cancer (Solid Tumors) and BI 765179 in Combination With Pembrolizumab in Patients With Advanced Head and Neck Cancer

151 enrolled

Neoplasms

NCT06880549 2026-05-27

A Study of mRNA-4106 or mRNA-4200 Administered Alone or in Combination With Anti-Cancer Agents in Participants With Solid Tumors

42 enrolled

Dermatologic

Melanoma, Neoplasm Metastasis, Neoplasms, Recurrence

NCT07410117 2026-05-27

ROXI-CAT-I

1,120 enrolled

Classical hematology

Hemorrhage, Neoplasms, Pulmonary Embolism, Venous Thrombosis, Venous Thromboembolism

NCT07438782 2026-05-27

First Time in Human (FTIH) Study to Investigate the Safety and Preliminary Activity of GSK5533524 Alone or in Combination in Adult Participants With Advanced Solid Tumors

97 enrolled

Phase 3 Active not recruiting

Neoplasms

NCT05445778 2026-05-26

GLORIOSA

520 enrolled

Gynecologic

Fallopian Tube Neoplasms, Neoplasms, Ovarian Neoplasms

NCT06051695 2026-05-26

EVEREST-2

GastrointestinalGynecologicOther solid neoplasmThoracic

474 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Recurrence, Colorectal Neoplasms

NCT06533059 2026-05-26

A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors

BreastGenitourinaryGynecologic

110 enrolled

Breast Neoplasms, Uterine Cervical Neoplasms, Genital Neoplasms, Female, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT07209111 2026-05-26

KANDLELIT-014

150 enrolled

Neoplasms

NCT07252739 2026-05-26

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

130 enrolled

Parkinson Disease 4, Autosomal Dominant Lewy Body, Neoplasms

NCT07302347 2026-05-26

MK-3475-G21

20 enrolled

DermatologicLymphoid

Lymphoma, Neoplasms, Carcinoma, Merkel Cell

NCT01946477 2026-05-22

POM MM 014

Phase 2 Completed

186 enrolled 17 charts

Plasma cell

Multiple Myeloma, Neoplasms, Plasmacytoma

NCT05277051 2026-05-22

First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

152 enrolled

Squamous Cell Carcinoma of Head and Neck, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT05673018 2026-05-22

Galleri® in the Medicare Population.

50,000 enrolled

Neoplasms

NCT05768139 2026-05-22

PIKALO-1

BreastGynecologicHead & Neck

880 enrolled

Squamous Cell Carcinoma of Head and Neck, Breast Diseases, Breast Neoplasms, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Neoplasms, Neoplasms by Site, Hereditary Sensory and Autonomic Neuropathies, Ovarian Neoplasms, Endometrial Neoplasms

NCT05920356 2026-05-22

A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

Phase 2 Active not recruiting

750 enrolled

Thoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Neoplasms

NCT06413706 2026-05-22

A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy

45 enrolled

CNS

Brain Neoplasms, Glioma, Neoplasms, Spinal Cord Neoplasms

NCT06431594 2026-05-22

BEHOLD-1

675 enrolled

Neoplasms

NCT06551142 2026-05-22

PanTumor-101

845 enrolled

Neoplasms

NCT06796907 2026-05-22

BEHOLD-2

305 enrolled

Neoplasms

NCT07005102 2026-05-22

A Study to Assess Adverse Events, Change in Disease Activity of Intravenous Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Adult Participants With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

Phase 2/3 Recruiting

854 enrolled

Neoplasms

NCT07023289 2026-05-22

A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

140 enrolled

Gastrointestinal

Neoplasms, Colorectal Neoplasms

NCT07377487 2026-05-22

INDIGO

EndocrineGastrointestinalNET

51 enrolled

Carcinoma, Colonic Diseases, Digestive System Diseases, Digestive System Neoplasms, Carcinoma, Hepatocellular, Liver Diseases, Liver Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Colorectal Neoplasms, Carcinoma, Neuroendocrine, Neuroendocrine Tumors

NCT07578571 2026-05-22

A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

BreastGastrointestinalThoracic

175 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT07600749 2026-05-22

Clinical Study of MK-4884 in Participants With Advanced or Metastatic Solid Tumors (MK-4884-001)

Phase 1 Not yet recruiting

120 enrolled

Phase 1 Not yet recruiting

Neoplasms

NCT07603479 2026-05-22

A Phase I Study of JL19001 Injection Alone or in Combination With Standard Therapy in Patients With Advanced Solid Tumors or Relapsed/Refractory B-cell Non-Hodgkin Lymphoma

14 enrolled

Lymphoid

Lymphoma, Non-Hodgkin, Neoplasms

NCT03194893 2026-05-20

A Rollover Study of Alectinib in Patients With Anaplastic Lymphoma Kinase (ALK)-Positive or Rearranged During Transfection (RET)-Positive Cancer

Phase 3 Active not recruiting

200 enrolled

EndocrineThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasms, Multiple Endocrine Neoplasia Type 2a

NCT05538130 2026-05-20

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

CNSDermatologicHead & NeckThoracic

124 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Glioma, Melanoma, Neoplasms, Thyroid Neoplasms

NCT06989437 2026-05-20

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

Phase 2/3 Recruiting

982 enrolled

Gastrointestinal

Anorexia, Cachexia, Fatigue, Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms, Weight Loss

NCT07112196 2026-05-20

VINCIT

Phase 2/3 Recruiting

518 enrolled

Anorexia, Cachexia, Neoplasms, Weight Loss

NCT03530397 2026-05-19

A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors

400 enrolled

Diabetes Mellitus, Insulin-Dependent, 12, Neoplasms

NCT04130542 2026-05-19

Phase 1 Trial of LVGN6051 as Single Agent and in Combination With Keytruda (Pembrolizumab) in Advanced or Metastatic Malignancy

Phase 1 Completed

105 enrolled

Neoplasms

NCT04635995 2026-05-19

Phase 1 Trial of LVGN7409 (CD40 Agonist Antibody) as Single Agent and Combination Therapies in Advanced or Metastatic Malignancy

Phase 1 Completed

66 enrolled

Phase 3 Enrolling by invitation

Neoplasms

NCT05303532 2026-05-19

ROSY-D

214 enrolled

Neoplasms

NCT05650632 2026-05-19

A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma

210 enrolled

Plasma cell

Multiple Myeloma, Neoplasms

NCT06119581 2026-05-19

SUNRAY-01

1,264 enrolled

Thoracic

Bronchial Neoplasms, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Lung Diseases, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Neoplasms by Site, Neoplastic Processes, Pathologic Processes, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms

NCT07024784 2026-05-19

A Study to Assess Change in Disease Activity and Adverse Events in Adult Participants With Gynecologic Cancers Receiving Intravenous Infusion of IMGN151 as Monotherapy or in Combination With Other Therapies

377 enrolled

Gynecologic

Fallopian Tube Neoplasms, Neoplasms

NCT07167381 2026-05-19

xDRIVE for Florida-based Cancer Patients

LymphoidOther hematologic neoplasm

210 enrolled

Leukemia, Lymphoma, Neoplasms, Recurrence

NCT07387471 2026-05-19

Study to Assess Change in Disease Activity of Oral Venetoclax in Adult Participants With Recurring Relapsed or Refractory (R/R) Waldenström Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL)

14 enrolled

Lymphoid

Waldenstrom Macroglobulinemia, Neoplasms, Lymphoma, B-Cell, Marginal Zone

NCT07409246 2026-05-19

A Study to Evaluate Adverse Events, Change in Disease Activity, Tolerability, and How Intravenous ABBV-438 Moves Through the Body in Adult Participants With Multiple Myeloma (MM)

Other hematologic neoplasm

127 enrolled

Plasma cell

Multiple Myeloma, Neoplasms

NCT04742101 2026-05-18

Phase I/II Trial of S65487 Plus Azacitidine in Acute Myeloid Leukemia

Phase 1/2 Completed

57 enrolled

Neoplasms, Leukemia, Myeloid, Acute

NCT05123482 2026-05-18

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

Phase NA Enrolling by invitation

460 enrolled

BreastGynecologic

Breast Neoplasms, Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms

NCT06883058 2026-05-18

CASA

30 enrolled

Neoplasms

NCT07094204 2026-05-18

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

364 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT07465796 2026-05-18

CIPHER

10 enrolled

CNS

Glioma, Neoplasms

NCT05462717 2026-05-15

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors