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Phase

Phase 2 4Phase 3 2Phase 1 2Phase NA 1Phase 4 1Phase 1/2 1

Status

Recruiting 1Active not recruiting 1

Sponsor Class

NIH 1INDUSTRY 1

Study Type

Interventional 2

Sponsor

Cancer Type

CNS 2Sarcoma 1Other hematologic neoplasm 1Lymphoid 1

Conditions

Carcinoma, Non-Small-Cell Lung 176Neoplasm Metastasis 143Neoplasms 137Leukemia, Myeloid, Acute 131Colorectal Neoplasms 129Breast Neoplasms 117Ovarian Neoplasms 89Prostatic Neoplasms 88Melanoma 88Recurrence 85Multiple Myeloma 80Pancreatic Neoplasms 74Squamous Cell Carcinoma of Head and Neck 73Lung Neoplasms 72Glioblastoma 72Lymphoma, Non-Hodgkin 63Myelodysplastic Syndromes 61Triple Negative Breast Neoplasms 58Stomach Neoplasms 53Glioma 53Precursor Cell Lymphoblastic Leukemia-Lymphoma 50Carcinoma, Renal Cell 48Small Cell Lung Carcinoma 47Endometrial Neoplasms 47Lymphoma, Large B-Cell, Diffuse 45Brain Neoplasms 43Carcinoma, Hepatocellular 41Lymphoma, B-Cell 40Advanced Solid Tumors 40Sarcoma 39

Interventions

AZD 6244 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Phase 1 × Neurofibroma, Plexiform × 90 days × Clear all
NCT02390752 2026-06-01

Phase I Trial of TURALIO(R) (Pexidartinib, PLX3397) in Children and Young Adults With Refractory Leukemias and Refractory Solid Tumors Including Neurofibromatosis Type 1 (NF1) Associated Plexiform Neurofibromas (PN) and Tenosynovial Giant Cell Tumor ...

National Institutes of Health Clinical Center (CC)

Phase 1 Recruiting
54 enrolled
CNSLymphoidOther hematologic neoplasmSarcoma

Sarcoma, Leukemia, Myeloid, Acute, Leukemia, Promyelocytic, Acute, Neurofibroma, Plexiform, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT04590235 2026-05-14

A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

AstraZeneca

Phase 1 Active not recruiting
32 enrolled
CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

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