Clinical Trials Browser

Astrocytoma, Ganglioneuroma, Glioblastoma, Glioma, Histiocytosis, Langerhans-Cell, Neuroblastoma, Neurofibromatosis 1, Oligodendroglioma, Ganglioglioma, Neurocytoma, Neurofibroma, Plexiform

NCT01362803 2026-06-01

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

Phase 1/2 Active not recruiting

99 enrolled 1 FDA

CNS

Neurofibromatosis 1, Pain, Neurofibroma, Plexiform

NCT05363267 2026-06-01

NF-1, Nutraceutical Intervention

Phase 1 Active not recruiting

23 enrolled

CNS

Neurofibromatosis 1

NCT06188741 2026-05-29

NF114

Phase 2 Recruiting

200 enrolled

CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT03190915 2026-05-27

Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

Phase 2 Active not recruiting

10 enrolled 11 charts

CNSOther hematologic neoplasm

Neurofibromatosis 1, Leukemia, Myelomonocytic, Juvenile

NCT03433183 2026-05-27

SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

Phase 2 Completed

21 enrolled 12 charts

CNSSarcoma

Neurofibromatosis 1, Neurofibrosarcoma

NCT05101148 2026-05-20

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

Phase 1 Active not recruiting

24 enrolled

CNS

Neurofibromatosis 1

NCT06541847 2026-05-19

INSPIRE-NF1

Phase 2 Recruiting

25 enrolled

CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT04590235 2026-05-14

A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

Phase 1 Active not recruiting

32 enrolled

CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

Clinical Trials

DoDNAC

Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas

A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1)

PF-07284892 in Participants With Advanced Solid Tumors

Assessing the Efficacy of Repeat, Monthly Treatments of Alexandrite Laser for NF1-associated Cutaneous Neurofibromas (cNFs)

Pediatric Long-Term Follow-up and Rollover Study

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

NF-1, Nutraceutical Intervention

NF114

Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

INSPIRE-NF1

A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)