Clinical Trials Browser

Attention Deficit Disorder with Hyperactivity, Neurofibromatosis 1

NCT03433183 2026-05-27

SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

Phase 2 Completed

21 enrolled 12 charts

CNSSarcoma

Neurofibromatosis 1, Neurofibrosarcoma

NCT04481035 2026-04-21

NF1NAC

Phase 2 Completed

5 enrolled 10 charts

CNS

Neurofibromatosis 1

NCT05005845 2026-02-17

NFX-179 Topical Gel Treatment for Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF)

Phase 2 Completed

199 enrolled 15 charts

CNS

Neurofibromatosis 1

NCT00624234 2025-07-08

Neurobiology and Treatment of Reading Disability in NF-1

Phase NA Completed

184 enrolled 10 charts

CNS

Dyslexia, Learning Disabilities, Neurofibromatosis 1

NCT05912400 2025-05-08

Evaluating Mitochondrial Dysfunction in Patients With Neurofibromatosis Type 1

Completed

55 enrolled 19 charts

CNS

Neurofibromatosis 1

NCT03231306 2025-05-02

NF108-BINI

Phase 2 Completed

45 enrolled 8 charts

CNS

Neurofibroma, Neurofibromatosis 1, Peripheral Nervous System Neoplasms, Neurofibromatoses, Neurofibroma, Plexiform

NCT04561765 2025-03-30

Innovation in the Treatment of Persistent Pain in Adults With NF1: Implementation of the iCanCope Mobile Application- Clinical Trial

Phase NA Completed

122 enrolled 21 charts

CNS

Neurofibromatosis 1, Chronic Pain

NCT01553149 2025-01-07

Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma

Phase 2 Completed

75 enrolled 17 charts

CNS

Astrocytoma, Neurofibromatosis 1, Optic Nerve Glioma

NCT03531814 2024-06-11

Medication Adherence in Children, Adolescents and Adults With Neurofibromatosis Type 1(NF1) on Clinical Treatment Trials

Phase NA Completed

12 enrolled 18 charts

CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT02332902 2023-12-20

DCLNF1

Phase 2 Completed

24 enrolled 4 charts

CNS

Neurofibroma, Neurofibromatosis 1

NCT02839720 2023-12-06

Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma

Phase 2 Completed

11 enrolled 11 charts

CNS

Neurofibromatosis 1, Optic Nerve Glioma

NCT00846430 2023-08-30

Medical Treatment of "High-Risk" Neurofibromas

Phase 2 Completed

9 enrolled 9 charts

CNS

Neurofibroma, Neurofibromatosis 1

NCT04435665 2022-08-09

NFX-179 Topical Gel Treatment in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF)

Phase 2 Completed

48 enrolled 14 charts

CNS

Neurofibromatosis 1

NCT02471339 2022-06-14

Acceptance and Commitment Training for Adolescents and Young Adults With Neurofibromatosis Type 1, Plexiform Neurofibromas, and Chronic Pain

Phase 3 Completed

66 enrolled 17 charts

CNS

Neurofibromatosis 1, Neurofibroma, Plexiform

NCT01125046 2021-01-22

Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas

Phase 2 Completed

50 enrolled 13 charts

CNS

Brain Neoplasms, Ependymoma, Meningioma, Neurofibromatosis 1, Neuroma, Acoustic, Neurofibromatosis 2

NCT02096471 2019-01-10

MEK Inhibitor

Phase 2 Completed

19 enrolled 14 charts

CNS

Neurofibroma, Neurofibromatosis 1

NCT00304083 2018-09-18

Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath Tumors

Phase 2 Completed

48 enrolled 10 charts

CNSSarcoma

Neurofibromatosis 1, Sarcoma, Neurofibrosarcoma

NCT00030264 2018-08-08

Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform Neurofibromas

Phase 2 Completed

23 enrolled 9 charts

CNSOther neoplasm

Neurofibromatosis 1, Precancerous Conditions, Neurofibroma, Plexiform

NCT00076102 2018-04-23

Pirfenidone in Children and Young Adults With Neurofibromatosis Type I and Progressive Plexiform Neurofibromas

Phase 2 Completed

36 enrolled 13 charts

CNS

Neurofibromatosis 1, Nerve Sheath Neoplasms, Neurofibroma, Plexiform

NCT00021541 2018-04-17

R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas

Phase 2 Completed

62 enrolled 13 charts

CNS

Neurofibroma, Neurofibromatosis 1, Neurofibromatoses, Neurofibroma, Plexiform

NCT00853580 2018-03-12

STARS

Phase 2 Completed

146 enrolled 29 charts

CNS

Neurofibromatosis 1

NCT00634270 2017-11-17

Protocol 102

Phase 2 Completed

58 enrolled 19 charts

CNS

Neurofibromatosis 1

NCT00589784 2016-01-25

Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma

Phase 2 Completed

50 enrolled 6 charts

CNS

Brain Neoplasms, Meningioma, Neurofibromatosis 1, Neurofibromatosis 2, Central Nervous System Neoplasms, Neurofibromatoses, Hemangioblastoma

Clinical Trials

DoDNAC

SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

NF1NAC

NFX-179 Topical Gel Treatment for Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF)

Neurobiology and Treatment of Reading Disability in NF-1

Evaluating Mitochondrial Dysfunction in Patients With Neurofibromatosis Type 1

NF108-BINI

Innovation in the Treatment of Persistent Pain in Adults With NF1: Implementation of the iCanCope Mobile Application- Clinical Trial

Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma

Medication Adherence in Children, Adolescents and Adults With Neurofibromatosis Type 1(NF1) on Clinical Treatment Trials

DCLNF1

Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma

Medical Treatment of "High-Risk" Neurofibromas

NFX-179 Topical Gel Treatment in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF)

Acceptance and Commitment Training for Adolescents and Young Adults With Neurofibromatosis Type 1, Plexiform Neurofibromas, and Chronic Pain

Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas

MEK Inhibitor

Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath Tumors

Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform Neurofibromas

Pirfenidone in Children and Young Adults With Neurofibromatosis Type I and Progressive Plexiform Neurofibromas

R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas

STARS

Protocol 102

Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma