Announcements Trials
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Phase

Phase 2 9Phase 1/2 5Phase 1 4Phase 3 1

Status

Active not recruiting 3Not yet recruiting 1Completed 1

Sponsor Class

OTHER 2NIH 2INDUSTRY 1

Study Type

Interventional 5

Sponsor

Cancer Type

CNS 5Sarcoma 1

Conditions

Neurofibromatosis 1 5Carcinoma, Non-Small-Cell Lung 3Pancreatic Neoplasms 2Neurofibroma, Plexiform 2Triple Negative Breast Neoplasms 1Sarcoma, Kaposi 1Precursor Cell Lymphoblastic Leukemia-Lymphoma 1Pain 1Optic Nerve Glioma 1Neurofibrosarcoma 1Neoplasms 1Lung Neoplasms 1Liver Neoplasms 1Gastrointestinal Neoplasms 1Colorectal Neoplasms 1Carcinoma, Hepatocellular 1Astrocytoma 1Acquired Immunodeficiency Syndrome 1AIDS-related Kaposi sarcoma 1

Interventions

AZD 6244 5trametinib 1fludarabine phosphate 1fludarabine 1abemaciclib 1Specimen Handling 1Injections 1Dosage Forms 1Cytarabine 1Azacitidine 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Phase 1/2 × Neurofibromatosis 1 × AZD 6244 × Clear all
NCT01362803 2026-06-01

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

National Institutes of Health Clinical Center (CC)

Phase 1/2 Active not recruiting
99 enrolled 1 FDA
CNS

Neurofibromatosis 1, Pain, Neurofibroma, Plexiform

NCT01089101 2026-05-13

Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma

National Cancer Institute (NCI)

Phase 1/2 Active not recruiting
217 enrolled
CNS

Astrocytoma, Neurofibromatosis 1

NCT05309668 2025-12-18

SPRINKLE

AstraZeneca

Phase 1/2 Active not recruiting
36 enrolled 37 charts
CNS

Neurofibromatosis 1

NCT06735820 2025-07-03

MEKMDM2

Children's National Research Institute

Phase 1/2 Not yet recruiting
45 enrolled
CNSSarcoma

Neurofibromatosis 1, Neurofibrosarcoma

NCT03326388 2024-04-04

INSPECT

Great Ormond Street Hospital for Children NHS Foundation Trust

Phase 1/2 Completed
14 enrolled
CNS

Neurofibromatosis 1, Neurofibroma, Plexiform, Optic Nerve Glioma

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